Overview of drugs that can lead to the development of oral mucosal diseases, xerostomia or alterations of taste perception
| Diseases of the oral mucosa | Medications group | Active substance |
|---|---|---|
| stomatitis medicamentosa (drug-induced stomatitis) | antianginal drugs | Nicorandil |
| ATB | metronidazole, penicillin, erythromycin, tetracycline | |
| antiepileptics | clonazepam, hydantoins, lamotrigin | |
| antidepressants | imipramine, fluoxetine | |
| antihypertensives | captopril, enalapril, propranolol | |
| antiretrovirotics | ritonavir, saquinavir, zidovudine | |
| antimalarials | chloroquine | |
| chemotherapeutics | cisplatin, cyclosporine, doxorubicin, methotrexate, vincristine | |
| anti-inflammatory drugs | ibuprofen, salicylic acid, naproxen, indomethacin | |
| immunosuppressants | sirolimus | |
| ulcerations and mucositis | cardiac drugs (beta blockers, ACE inhibitors) | propranolol, captopril |
| sympathomimetics | methyldopa | |
| sedatives | barbiturates | |
| anxiolytics | meprobamate | |
| ATB | sulfonamides, tetracyclines | |
| urological drugs | tadalafil | |
| laxatives | phenolphtalein | |
| diuretics | thiazide derivatives, spironolactone | |
| antidiabetics | tolbutamide | |
| bisphosphonates | alendronate | |
| NSAIDs | salicylates, indomethacin, Au salts, naproxen, phenazone derivatives | |
| antirheumatics | penicillamine, phenylbutazone | |
| antiepileptics | phenytoin | |
| antineoplastics | methotrexate, 5-fluorouracil, doxorubicin, melphalan | |
| chemotherapeutics imunomodulators | dapsone | |
| antiseptics | hydrogen peroxide, phenol, potassium tablets | |
| swellings | ATBs | penicillin and its derivatives, sulphonamide, cephalosporin |
| NSAIDs cardiac drugs (ACE inhibitors) | acetylsalicylic acid | |
| sedatives | barbiturates | |
| xerostomia and hyposalivation | sympatholytics | |
| sympathomimetics (beta2-agonists) | ||
| retinoids | ||
| cytotoxic agents | ||
| muscle relaxants | ||
| decongestants | ||
| antihistamines | ||
| antihypertensives | ||
| diuretics | ||
| protease inhibitors | ||
| proton pump inhibitors, antacids | ||
| antimuscarinic agents, anticholinergics | ||
| antidepressants | ||
| sedatives | ||
| anxiolytics | ||
| anti-inflammatory drugs | ||
| opioids and cannabinoids | ||
| antiparkinsonics | ||
| antiepileptics | ||
| increased susceptibility to infection (oral candidosis) | ATBs | |
| immunosuppressants | ||
| corticosteroids | ||
| chemotherapeutics | ||
| gingival hyperplasia | antiepileptics | phenytoin, valproate |
| antihypertensives (calcium channel blockers) | nifedipine, amlodipine, diltiazem, verapamil | |
| cardiac drugs (dihydropyridines) | bleomycin | |
| chemotherapeutics | cyclosporine | |
| immunosuppressants | ||
| oestrogens | ||
| increased gingival bleeding | anticoagulants | |
| NSAIDs | acetylsalicylic acid | |
| altered taste perception | cardiac drugs (beta blockers, calcium channel blockers) | |
| neurostimulants | ||
| ATB | metronidazole | |
| others | nicotine | |
| pigmentations | laxatives | phenolphthalein |
| cardiac drugs (potassium channel blockers) | amiodarone | |
| antimalarials | chloroquine | |
| oestrogens | ||
| sedatives | chlorpromazine | |
| antivirotics | zidovudine | |
| cytostatics | clofazimine | |
| antimycotics | ketoconazole | |
| antineoplastics | imatinib | |
| chemotherapeutics | busulfan | |
| cytostatics | cyclophosphamide | |
| ATB | tetracycline (minocycline) | |
| OLL | anti-alcohol drugs | cyanamide |
| antihyperuricemics | allopurinol | |
| antidiarrheals | bismuth | |
| antidiabetics | chlorpropamide, glipizide, insulin, tolbutamide | |
| antihistaminics | cimetidine, cinnarizine, triprolidine | |
| antimycotics | amphotericin B, ketoconazole | |
| antiretrovirotics | zidovudine | |
| antihypertensives | atenolol, beta blockers, captopril, chlorothiazide, enalapril, furosemide, hydrochlorothiazide, methyldopa, metoprolol, oxprenolol, propranolol, spironolacton | |
| antiepileptics | carbamazepine, oxacarbazepine, phenytoin, valproate | |
| NSAIDs | salicylates, diflunisal, ibuprofen, indomethacin, naproxen, rofecoxib, sulindac | |
| antimalarials | quinine derivatives, pyrimethamine | |
| ATB | isoniazid, rifampicin, streptomycin, tetracyclines | |
| cardiac drugs (ACE inhibitors, beta blockers, potassium channel blockers) | flunarisine | |
| chemotherapeutics | dactinomycin, imatinib, palladium | |
| immunomodulators | dapsone, Au salts, levamisole, interferon alpha | |
| antirheumatics | penicillamine | |
| psychopharmaceuticals (benzodiazepines, tricyclic antidepressants) | levomepromazin, lithium, lorazepam, phenothiazines, pyritinol | |
| diuretics | furosemide | |
| EEM and Stevens-Johnson syndrome | ATB | penicillins, sulfonamides, tetracyclines, amoxicillin, clavulanic acid |
| antimalarials | ||
| antihyperuricemics | allopurinol | |
| psychopharmaceuticals | barbiturates | |
| protease inhibitors | ||
| NSAIDs | ||
| antiepileptics | phenytoin, lamotrigin | |
| pemphigus | NSAIDs | ibuprofen, piroxicam, Au salts |
| antirheumatics | phenylbutazone, penicillamine | |
| antidiabetics | glibenclamide | |
| antitubercular drugs | ethambutol | |
| diuretics | theobromine | |
| cardiac drugs (beta blockers) | propranolol, captopril, practolol | |
| psychopharmaceuticals | barbiturates (phenobarbital), pyritinol, heroin | |
| ATB | ampicillin, cephalexin, rifampicin | |
| others | thiopyridoxine, mercaptopropionyl glycine | |
| pemphigoid | ATB | penicillins, sulfonamides |
| antirheumatics, NSAIDs | penicillamine, ibuprofen, phenacetin | |
| cardiac drugs | furosemide, captopril, clonidine | |
| LE-like reactions | ATB | streptomycin |
| antirheumatics | penicillamine | |
| NSAIDs | Au salts | |
| psychopharmaceuticals | lithium, chlorpromazine | |
| sympathomimetics | methyldopa | |
| antimalarials | quinine derivatives | |
| antiepileptics | carbamazepine, ethosuximide, hydantoins, primidone, trimethadion | |
| antimitotics | griseofulvin | |
| antitubercular drugs | isoniazid | |
| antiarrhytmics | procainamide | |
| antihypertensives | reserpine | |
| vazodilatints | hydralazine | |
| others | thiouracil |