ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Francová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. 11:30–12:20 B11/114, Mon 26. 2. 11:30–12:20 B11/114, Mon 4. 3. 11:30–12:20 B11/114, Mon 11. 3. 11:30–12:20 B11/114, Mon 18. 3. 11:30–12:20 B11/114, Mon 25. 3. 11:30–12:20 B22/116 aula, Mon 8. 4. 11:30–12:20 B11/114, Mon 15. 4. 11:30–12:20 B11/114, Mon 22. 4. 11:30–12:20 B11/114, Mon 29. 4. 11:30–12:20 B11/114, Mon 6. 5. 11:30–12:20 B11/114, Mon 13. 5. 11:30–12:20 B11/114, Mon 20. 5. 11:30–12:20 B11/114
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended to study for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of the basic principles of human genetics
- understanding of the mechanisms of cancer development
- acquaintance with the basics of genomics, immunogenetics, epigenetics, gene therapy, tissue engineering, evolutionary biology, human ontogenesis
Learning outcomes
After completing the course, the student will be able to:
- explain and apply basic principles of human genetics
- explain the role of medical biology in the development of modern therapies (e.g. molecular therapies of cancer)
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome in human health and disease
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics)
Syllabus
  • Introduction to Genetics I – Genetics in Medicine, Mendelian Inheritance, Autosomal and Gonosomal Inheritance, Chromosome Abnormalities
  • Introduction to Genetics II – Multifactorial Inheritance, Genetic Linkage, Population Genetics
  • Human genome and methods of its study
  • Epigenetics – Interaction of Genes and Environment
  • Immunogenetics
  • Cancer Biology I – Carcinogenesis, Hallmarks of Cancer
  • Cancer Biology II – Oncogenes and tumour suppressors, oncogenic viruses
  • Bacterial and Viral Genomics
  • Use of knowledge of molecular biology and genetics in medicine
  • Gene Therapy
  • Human Microbiome
  • Stem Cells and Tissue Engineering
  • Evolutionary Biology
  • Introduction to human ontogenesis (pre- and postnatal development)
Literature
    required literature
  • SLABÝ, Ondřej. Lékařská biologie. 1. vydání. Brno: Masarykova univerzita, 2022, 268 stran. ISBN 9788028000608. info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. 2. aktual. vyd. Brno: Masarykova univerzita, 2017, 864 pp. ISBN 978-80-210-8613-5. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
Teaching methods
lecture every week
Assessment methods
The course of Biology II builds on the knowledge gained from Biology I and is completed with an oral exam based on topics discussed at lectures and practices of both semesters.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
Lectures take place every week. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week. https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2025
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Francová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended to study for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of the basic principles of human genetics
- understanding of the mechanisms of cancer development
- acquaintance with the basics of genomics, immunogenetics, epigenetics, gene therapy, tissue engineering, evolutionary biology, human ontogenesis
Learning outcomes
After completing the course, the student will be able to:
- explain and apply basic principles of human genetics
- explain the role of medical biology in the development of modern therapies (e.g. molecular therapies of cancer)
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome in human health and disease
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics)
Syllabus
  • Introduction to Genetics I – Genetics in Medicine, Mendelian Inheritance, Autosomal and Gonosomal Inheritance, Chromosome Abnormalities
  • Introduction to Genetics II – Multifactorial Inheritance, Genetic Linkage, Population Genetics
  • Human genome and methods of its study
  • Epigenetics – Interaction of Genes and Environment
  • Immunogenetics
  • Cancer Biology I – Carcinogenesis, Hallmarks of Cancer
  • Cancer Biology II – Oncogenes and tumour suppressors, oncogenic viruses
  • Bacterial and Viral Genomics
  • Use of knowledge of molecular biology and genetics in medicine
  • Gene Therapy
  • Human Microbiome
  • Stem Cells and Tissue Engineering
  • Evolutionary Biology
  • Introduction to human ontogenesis (pre- and postnatal development)
Literature
    required literature
  • SLABÝ, Ondřej. Lékařská biologie. 1. vydání. Brno: Masarykova univerzita, 2022, 268 stran. ISBN 9788028000608. info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. 2. aktual. vyd. Brno: Masarykova univerzita, 2017, 864 pp. ISBN 978-80-210-8613-5. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
Teaching methods
lecture every week
Assessment methods
The course of Biology II builds on the knowledge gained from Biology I and is completed with an oral exam based on topics discussed at lectures and practices of both semesters.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
Lectures take place every week. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week. https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2023
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Francová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 15. 2. 13:00–13:50 B11/234, Wed 22. 2. 13:00–13:50 B11/234, Wed 1. 3. 13:00–13:50 B11/234, Wed 8. 3. 13:00–13:50 B11/234, Wed 15. 3. 13:00–13:50 B11/234, Wed 22. 3. 13:00–13:50 B11/234, Wed 29. 3. 13:00–13:50 B11/234, Wed 5. 4. 13:00–13:50 B11/234, Wed 12. 4. 13:00–13:50 B11/234, Wed 19. 4. 13:00–13:50 B11/234, Wed 26. 4. 13:00–13:50 B11/234, Wed 3. 5. 13:00–13:50 B11/234, Wed 10. 5. 13:00–13:50 B11/234, Wed 17. 5. 13:00–13:50 B11/234
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended to study for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of the basic principles of human genetics
- understanding of the mechanisms of cancer development
- acquaintance with the basics of genomics, immunogenetics, epigenetics, gene therapy, tissue engineering, evolutionary biology, human ontogenesis
Learning outcomes
After completing the course, the student will be able to:
- explain and apply basic principles of human genetics
- explain the role of medical biology in the development of modern therapies (e.g. molecular therapies of cancer)
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome in human health and disease
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics)
Syllabus
  • Introduction to Genetics I – Genetics in Medicine, Mendelian Inheritance, Autosomal and Gonosomal Inheritance, Chromosome Abnormalities
  • Introduction to Genetics II – Multifactorial Inheritance, Genetic Linkage, Population Genetics
  • Human genome and methods of its study
  • Epigenetics – Interaction of Genes and Environment
  • Immunogenetics
  • Cancer Biology I – Carcinogenesis, Hallmarks of Cancer
  • Cancer Biology II – Oncogenes and tumour suppressors, oncogenic viruses
  • Bacterial and Viral Genomics
  • Use of knowledge of molecular biology and genetics in medicine
  • Gene Therapy
  • Human Microbiome
  • Stem Cells and Tissue Engineering
  • Evolutionary Biology
  • Introduction to human ontogenesis (pre- and postnatal development)
Literature
    required literature
  • SLABÝ, Ondřej. Lékařská biologie. 1. vydání. Brno: Masarykova univerzita, 2022, 268 stran. ISBN 9788028000608. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
    recommended literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. 2. aktual. vyd. Brno: Masarykova univerzita, 2017, 864 pp. ISBN 978-80-210-8613-5. info
Teaching methods
lecture every week
Assessment methods
The course of Biology II builds on the knowledge gained from Biology I and is completed with an oral exam based on topics discussed at lectures and practices of both semesters.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
Lectures take place every week. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week. https://is.muni.cz/auth/el/med/jaro2023/ZLBI0222p/index-ebtzDw.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 16. 2. 13:00–13:50 B11/234, Wed 23. 2. 13:00–13:50 B11/234, Wed 2. 3. 13:00–13:50 B11/234, Wed 9. 3. 13:00–13:50 B11/234, Wed 16. 3. 13:00–13:50 B11/234, Wed 23. 3. 13:00–13:50 B11/234, Wed 30. 3. 13:00–13:50 B11/234, Wed 6. 4. 13:00–13:50 B11/234, Wed 13. 4. 13:00–13:50 B11/234, Wed 20. 4. 13:00–13:50 B11/234, Wed 27. 4. 13:00–13:50 B11/234, Wed 4. 5. 13:00–13:50 B11/234, Wed 11. 5. 13:00–13:50 B11/234, Wed 18. 5. 13:00–13:50 B11/234
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended to study for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of the basic principles of human genetics
- understanding of the mechanisms of cancer development
- acquaintance with the basics of genomics, immunogenetics, epigenetics, gene therapy, tissue engineering and evolutionary biology
Learning outcomes
After completing the course, the student will be able to:
- explain and apply basic principles of human genetics
- explain the role of medical biology in the development of modern therapies (e.g. molecular therapies of cancer)
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome in human health and disease
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics)
Syllabus
  • Introduction to Genetics I – Genetics in Medicine, Mendelian Inheritance, Autosomal and Gonosomal Inheritance, Chromosome Abnormalities
  • Introduction to Genetics II – Multifactorial Inheritance, Genetic Linkage, Population Genetics
  • Human genome and methods of its study
  • Epigenetics – Interaction of Genes and Environment
  • Immunogenetics
  • Cancer Biology I – Carcinogenesis, Hallmarks of Cancer
  • Cancer Biology II – Oncogenes and tumour suppressors, oncogenic viruses
  • Bacterial and Viral Genomics
  • Use of knowledge of molecular biology and genetics in medicine
  • Gene Therapy
  • Human Microbiome
  • Stem Cells and Tissue Engineering
  • Evolutionary Biology
Literature
    required literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. 2. aktual. vyd. Brno: Masarykova univerzita, 2017, 864 pp. ISBN 978-80-210-8613-5. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
Teaching methods
lecture every week
Assessment methods
The course of Biology II builds on the knowledge gained from Biology I and is completed with an oral exam based on topics discussed at lectures and practices of both semesters.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/med/jaro2022/ZLBI0222p/index-ebtzDw.qwarp
Lectures take place every week. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week, and links to animations and videos relevant to the topic. https://is.muni.cz/auth/el/med/jaro2022/ZLBI0222p/index-ebtzDw.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
doc. Mgr. Jiří Šána, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 2. 3. 11:00–11:50 B11/234, Tue 9. 3. 11:00–11:50 B11/234, Tue 16. 3. 11:00–11:50 B11/234, Tue 23. 3. 11:00–11:50 B11/234, Tue 30. 3. 11:00–11:50 B11/234, Tue 6. 4. 11:00–11:50 B11/234, Tue 13. 4. 11:00–11:50 B11/234, Tue 20. 4. 11:00–11:50 B11/234, Tue 27. 4. 11:00–11:50 B11/234, Tue 4. 5. 11:00–11:50 B11/234, Tue 11. 5. 11:00–11:50 B11/234, Tue 18. 5. 11:00–11:50 B11/234, Tue 25. 5. 11:00–11:50 B11/234, Tue 1. 6. 11:00–11:50 B11/234
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended to study for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of the basic principles of human genetics
- understanding of the mechanisms of cancer development
- acquaintance with the basics of genomics, immunogenetics, epigenetics, gene therapy, tissue engineering and evolutionary biology
Learning outcomes
After completing the course, the student will be able to:
- explain and apply basic principles of human genetics
- explain the role of medical biology in the development of modern therapies (e.g. molecular therapies of cancer)
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome in human health and disease
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics)
Syllabus
  • Introduction to Genetics I – Genetics in Medicine, Mendelian Inheritance, Autosomal and Gonosomal Inheritance, Chromosome Abnormalities
  • Introduction to Genetics II – Multifactorial Inheritance, Genetic Linkage, Population Genetics
  • Human genome and methods of its study
  • Epigenetics – Interaction of Genes and Environment
  • Immunogenetics
  • Cancer Biology I – Carcinogenesis, Hallmarks of Cancer
  • Cancer Biology II – Oncogenes and tumour suppressors, oncogenic viruses
  • Bacterial and Viral Genomics
  • Use of knowledge of molecular biology and genetics in medicine
  • Gene Therapy
  • Human Microbiome
  • Stem Cells and Tissue Engineering
  • Evolutionary Biology
Literature
    required literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. 2. aktual. vyd. Brno: Masarykova univerzita, 2017, 864 pp. ISBN 978-80-210-8613-5. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
Teaching methods
lecture every week
Assessment methods
The course of Biology II builds on the knowledge gained from Biology I and is completed with an oral exam based on topics discussed at lectures and practices of both semesters.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2021/ZLBI0222p/index.qwarp
Lectures take place every week. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week, and links to animations and videos relevant to the topic (https://is.muni.cz/auth/el/1411/jaro2021/ZLBI0222p/index.qwarp)
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Jana Růžičková (assistant)
Mgr. Kateřina Straková, Ph.D. (alternate examiner)
Guaranteed by
prof. MUDr. David Šmajs, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 19. 2. 13:00–13:50 B11/327, Wed 26. 2. 13:00–13:50 B11/327, Wed 4. 3. 13:00–13:50 B11/327, Wed 11. 3. 13:00–13:50 B11/327, Wed 18. 3. 13:00–13:50 B11/327, Wed 25. 3. 13:00–13:50 B11/327, Wed 8. 4. 13:00–13:50 B11/327, Wed 15. 4. 13:00–13:50 B11/327, Wed 6. 5. 13:00–13:50 B11/327
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended for studying before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course, the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during the development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
Syllabus
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • The paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • The human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    not specified
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014, xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013, 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. The course of Biology II builds on the knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2020/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2019
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:00–9:50 B11/114
Prerequisites
ZLBI0121c Biology I - pract. && ZC011 Handling chemical substances
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
Syllabus
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • Paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • Human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    not specified
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014, xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013, 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. The course of Biology II builds on knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2018/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2018
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (seminar tutor)
Mgr. Kateřina Straková, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. to Sun 13. 5. Wed 9:30–10:20 B11/114, Mon 28. 5. to Sun 3. 6. Wed 9:30–10:20 Kinosál N02901
Prerequisites
ZLBI0121c Biology I - pract. && ZC011 Handling chemical substances
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
Syllabus
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • Paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • Human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    not specified
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014, xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013, 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. The course of Biology II builds on knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2018/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2017
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
Prerequisites
ZLBI0121c Biology I - pract. && ZC011 Handling chemical substances
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; knows basic principles of bacterial and viral diseases; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects, and understands the principle of genetic determination of hereditary diseases; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
Learning outcomes
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; knows basic principles of bacterial and viral diseases; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects, and understands the principle of genetic determination of hereditary diseases; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
Syllabus
  • 1. week:
  • DNA damage and repair – from molecular mechanisms to clinical significance (doc. Mgr. Lumír Krejčí, Ph.D.)
  • 2. week:
  • Introduction to cancer biology (Mgr. Stjepan Uldrijan, CSc.)
  • 3. week:
  • Oncogenes and oncoviruses in cancer transformation (Mgr. Stjepan Uldrijan, CSc.)
  • 4. week:
  • Tumour suppressor genes and their significance for diagnostics and therapy (Mgr. Stjepan Uldrijan, CSc.)
  • 5. week:
  • Paradigm of cancer stem cells and implications for anti-cancer therapies (doc. MUDr. Iva Slaninová, Ph.D.)
  • 6. týden:
  • Gene therapy – targets and strategies of molecular therapies (doc. MUDr. Iva Slaninová, Ph.D.)
  • 7. week:
  • Stem cells and tissue engineering – prospects of regenerative medicine (prof. Ing. Petr Dvořák, CSc.)
  • 8. week:
  • From a single cell to human I – introduction to developmental biology (Mgr. Vladimír Rotrekl, Ph.D.)
  • 9. week:
  • From a single cell to human II – molecular basis of mammalian development in health and disease (Mgr. Pavel Krejčí, Ph.D.)
  • 10. week:
  • Human genome and genomics in current biomedicine (prof. MUDr. David Šmajs, Ph.D.)
  • 11. week:
  • Human microbiome (prof. MUDr. David Šmajs, Ph.D.)
  • 12. week:
  • Bioinformatics in medicine – from molecules to populations (Mgr. Vladimír Rotrekl, Ph.D.)
  • 13. week:
  • Modern approaches in studying macromolecules and their use in current biomedicine (Mgr. Vladimír Rotrekl, Ph.D.)
  • 14. week:
  • Substitution lecture
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    recommended literature
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012, xxviii, 79. ISBN 9780321709783. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • WEINBERG, Robert A. The biology of cancer. Second edition. London: Garland Science, 2013, xx, 876. ISBN 9780815345282. info
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
    not specified
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
Teaching methods
lecture
Assessment methods
The course Biology II builds on knowledge gained from subject Biology I - lecture (aZLBI0121p) and is completed with a written examination test taken on computers. It contains questions based on the topics discussed in the lectures and practices. The students are expected to be able to solve given problems on their own, and to derive the solutions by their own consideration based on the theory discussed in the course of both semesters and supplemented by the recommended reading.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2017/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2016
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
doc. Yuh-Man Wadeley, Doctor of Philosophy (lecturer)
Jana Růžičková (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
Prerequisites
ZLBI0121c Biology I - pract. && ZC011 Handling chemical substances
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; is able to deduce and explain the difference between healthy and pathologically-working cell; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
Syllabus
  • Week 1: 22.2. – 26.2. 2014
  • Growth factors and signal transduction in development and disease (Mgr. Pavel Krejčí, Ph.D.)
  • Week 2: 29.2. – 4.3.
  • Biology and use of stem cells in disease modelling and cell therapy (prof. Ing. Petr Dvořák, CSc.)
  • Week 3: 7.3. – 11.3.
  • Cell differentiation and tissue engineering (prof. Ing. Petr Dvořák, CSc.)
  • Week 4: 14.3. – 18.3.
  • Genome instability - from molecular mechanisms of damage and DNA repair to clinical implications (doc. Mgr. Lumír Krejčí, Ph.D)
  • Week 5: 21.3. – 25.3.
  • Introduction to cancer biology (Mgr. Stjepan Uldrijan, CSc.)
  • Week 6: 28.3. – 1.4.
  • Oncogenes and oncoviruses in cancer transformation (Mgr. Stjepan Uldrijan, CSc.)
  • Week 7: 4.4. – 8.4.
  • Tumour suppressor genes - implications for diagnostics and therapy (Mgr. Stjepan Uldrijan, CSc.)
  • Week 8: 11.4. – 15.4.
  • Paradigm of cancer stem cells (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 9: 18.4. – 22.4.
  • Molecular principle of genetically determined diseases (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 10: 25.4. – 29.4.
  • Objectives and strategies of molecular therapy (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 11: 2.5. – 6.5.
  • Genomics and other omics in current biomedicine (prof. MUDr. David Šmajs, Ph.D.)
  • Week 12: 9.5. – 13.5.
  • Human microbiome (prof. MUDr. David Šmajs, Ph.D.)
  • Week 13: 16.5. – 20.5.
  • Bioinformatics in medicine - from molecules to populations (Mgr. Vladimír Rotrekl, Ph.D.)
  • Week 14: 23.5. – 27.5.
  • substitution lecture
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    recommended literature
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012, xxviii, 79. ISBN 9780321709783. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • WEINBERG, Robert A. The biology of cancer. Second edition. London: Garland Science, 2013, xx, 876. ISBN 9780815345282. info
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
    not specified
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
Teaching methods
lecture
Assessment methods
The subject is completed with a written examination test, based on knowledge of all topics from both semesters (lectures, practices). The test contains 94 questions with 1 correct answer. Negative marking is obtained for incorrect answers. For successful passing the exam, minimum 64 points out of 188 are needed.
Requirements for attendance at the exam: successful passing of the autumn semester’s lecture and seminar, and successfull completion of Biology-practices of both autumn and spring semester.
Students have to bring their valid ICIS card to prove their identity at the exam. For more information on the test see: https://is.muni.cz/auth/el/1411/jaro2016/aZLBI0222p/op/Exam_information_and_instructions_ENG.pdf
Lecture attendance is optional.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
https://is.muni.cz/auth/el/1411/jaro2016/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2015
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. Yuh-Man Wadeley, Doctor of Philosophy (lecturer)
Mgr. Hana Hříbková, Ph.D. (seminar tutor)
Mgr. Kateřina Vopěnková, Ph.D. (seminar tutor)
Mgr. Kateřina Cetkovská, Ph.D. (assistant)
Jana Růžičková (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
  • Timetable of Seminar Groups:
ZLBI0222p/VLA: Wed 15:00–15:50 B11/234
Prerequisites (in Czech)
ZLBI0121c Biology I - pract. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; is able to deduce and explain the difference between healthy and pathologically-working cell; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
Syllabus
  • Week 1: 16.2. – 20.2. 2014
  • Growth factors and signal transduction in development and disease (Mgr. Pavel Krejčí, Ph.D.)
  • Week 2: 23.2. – 27.2.
  • Biology and use of stem cells in disease modelling and cell therapy (prof. Ing. Petr Dvořák, CSc.)
  • Week 3: 2.3. – 6.3.
  • Cell differentiation and tissue engineering (prof. Ing. Petr Dvořák, CSc.)
  • Week 4: 9.3. – 13.3.
  • Genome instability - from molecular mechanisms of damage and DNA repair to clinical implications (doc. Mgr. Lumír Krejčí, Ph.D)
  • Week 5: 16.3. – 20.3.
  • Introduction to cancer biology (Mgr. Stjepan Uldrijan, CSc.)
  • Week 6: 23.3. – 27.3.
  • Oncogenes and oncoviruses in cancer transformation (Mgr. Stjepan Uldrijan, CSc.)
  • Week 7: 30.3. – 3.4.
  • Tumour suppressor genes - implications for diagnostics and therapy (Mgr. Stjepan Uldrijan, CSc.)
  • Week 8: 6.4. – 10.4.
  • Paradigm of cancer stem cells (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 9: 13.4. – 17.4.
  • Molecular principle of genetically determined diseases (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 10: 20.4. – 24.4.
  • Objectives and strategies of molecular therapy (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 11: 27.4. – 1.5.
  • Genomics and other omics in current biomedicine (prof. MUDr. David Šmajs, Ph.D.)
  • Week 12: 4.5. – 8.5.
  • Human microbiome (prof. MUDr. David Šmajs, Ph.D.)
  • Week 13: 11.5. – 15.5.
  • Bioinformatics in medicine - from molecules to populations (Mgr. Vladimír Rotrekl, Ph.D.)
  • Week 14: 18.5. – 22.5.
  • Substitution lecture
Literature
    required literature
  • Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009, 1 sv. ISBN 9780815341307. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013, 1 online r. ISBN 9781118689028. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
    recommended literature
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012, xxviii, 79. ISBN 9780321709783. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics. 5th ed. Hoboken: John Wiley & Sons, Inc, 2009, xix, 823. ISBN 9780470388259. info
  • WEINBERG, Robert A. The biology of cancer. Second edition. London: Garland Science, 2013, xx, 876. ISBN 9780815345282. info
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
    not specified
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • CAMPBELL, Neil A. Biology. Edited by Jane B. Reece. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005, xl, 1231. ISBN 080537146X. info
Teaching methods
lecture
Assessment methods
Lecture attendance is optional.
The subject is completed with a written examination test, based on knowledge of all topics from both semesters (lectures, practices). The test contains 94 questions with 1 correct answer. Negative marking is obtained for incorrect answers. FFor successful passing the exam, minimum 64 points out of 188 are needed.
Requirements for attendance at the exam: successful passing of the autumn semester’s lecture and seminar, and successfull completion of Biology-practices of both autumn and spring semester.
Students have to bring their valid ICIS card to prove their identity at the exam. For more information on the test see: https://is.muni.cz/auth/el/1411/jaro2015/ZLBI0222p/op/Exam_information_and_instructions_ENG.pdf
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2014
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. Yuh-Man Wadeley, Doctor of Philosophy (lecturer)
Mgr. Hana Hříbková, Ph.D. (seminar tutor)
Mgr. Kateřina Vopěnková, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Eva Skalová (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
  • Timetable of Seminar Groups:
ZLBI0222p/ZLA: Wed 15:00–15:50 B11/234
Prerequisites (in Czech)
ZLBI0121c Biology I-pract. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; is able to deduce and explain the difference between healthy and pathologically-working cell; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
Syllabus
  • Week 1: 17.-21.2.
  • Basic principles and molecular mechanisms regulating early development of mammals - physiology and pathology
  • Week 2: 24.-28.2.
  • Biology and use of stem cells in disease modelling and cell therapy
  • Week 3: 3.-7.3.
  • Growth factors and signal transduction in development and disease
  • Week 4: 10.-14.3.
  • Cell differentiation and tissue engineering
  • Week 5: 17.-21.3.
  • Introduction to cancer biology
  • Week 6: 24.-28.3.
  • Oncogenes and oncoviruses in cancer transformation
  • Week 7: 31.3.-4.4.
  • Tumour suppressor genes - implications for diagnostics and
  • Week 8: 7.-11.4.
  • Paradigm of cancer stem cells
  • Week 9: 14.-18.4.
  • Molecular principle of genetically determined diseases
  • Week 10: 21.-25.4.
  • Objectives and strategies of molecular therapy
  • Week 11: 28.4.-2.5.
  • Genomics and other omics in current biomedicine
  • Week 12: 5.-9.5.
  • Bioinformatics in medicine - from molecules to populations
  • Week 13: 12.-16.5.
  • Milestones in biological sciences in context with advances in clinical medicine
  • Week 14: 19.-23.5.
  • Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the year 2013“
Literature
    recommended literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009, 1 sv. ISBN 9780815341307. info
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • CAMPBELL, Neil A. Biology. Edited by Jane B. Reece. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005, xl, 1231. ISBN 080537146X. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics. 5th ed. Hoboken: John Wiley & Sons, Inc, 2009, xix, 823. ISBN 9780470388259. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012, xxviii, 79. ISBN 9780321709783. info
  • JANISCH, Roman. Overview of General Biology. 2. rozšířené. Brno: Masarykova univerzita, 2010, 91 pp. ISBN 978-80-210-5187-4. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • POLLARD, Thomas D., William C. EARNSHAW and Jennifer LIPPINCOTT-SCHWARTZ. Cell biology. Illustrated by Graham T. Johnson. 2nd ed. Philadelphia, Pa.: Saunders/Elsevier, 2008, xix, 905. ISBN 9780808923527. info
  • WEINBERG, Robert A. The biology of cancer. Second edition. London: Garland Science, 2013, xx, 876. ISBN 9780815345282. info
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
Teaching methods
lecture
Assessment methods
Lecture attendance is optional. Subject is completed with a written examination test, based on knowledge of all topics from both semesters (lectures, practices). The test contains 94 questions with 1 correct answer. For successful passing the exam, minimum 62 points out of 188 are needed.
Requirements for attendance at the exam: successful passing of the autumn semester’s lecture (VSBI0121p) and practice (ZLBI0121c), and spring semester’s practice (ZLBI0222c). Students have to bring their valid ICIS card to prove their identity at the exam. For more information on the test see: https://is.muni.cz/auth/el/1411/podzim2013/ZLBI0121p/op/Biology_Exam_information_and_instructions_2013_2014.pdf
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2013
Extent and Intensity
1/2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. Yuh-Man Wadeley, Doctor of Philosophy (lecturer)
Mgr. Hana Hříbková, Ph.D. (seminar tutor)
Mgr. Kateřina Vopěnková, Ph.D. (seminar tutor)
Eva Skalová (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
Prerequisites (in Czech)
ZLBI0121c Biology I-pract. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent concepts of developmental biology and ontogeny, cell signalling, structural and epigenetic changes in the DNA, cancer biology, gene therapy and bioinformatics are discussed. The subject matter presented in this course will help to better understanding of other subjects including physiology, pathology and human and clinical genetics.
Syllabus
  • 1st week: 18.-22.2. 2013 Lecture: Introduction to developmental biology 2nd week: 25.2. – 1.3.2013 Lecture: Basic principles and molecular mechanisms regulating early development of mammals – physiology and pathology 3rd week: 4. – 8.3.2013 Lecture: Biology and use of stem cells in disease modelling and cell therapy 4th week: 11. – 15.3.2013 Lecture: Growth factors and signal transduction in development and disease 5th week: 18. – 22.3.2013 Lecture: Genome instability - from molecular mechanisms of damage and DNA repair to clinical implications 6th week: 25. – 29.3.2013 Lecture: Molecular principle of genetic diseases 7th week: 1. – 5.4.2013 Lecture: Introduction to cancer biology 8th week: 8. – 12.4.2013 Lecture: Oncogenes and oncoviruses in cancer transformation 9th week: 15. – 19.4.2013 Lecture: Tumour supressor genes – implications for diagnostics and therapy 10th week: 22. – 26.4.2013 Lecture: Paradigm of cancer stem cells 11th week: 29.4. – 3.5.2013 Lecture: Objectives and strategies of molecular therapy 12th week: 6. – 10.5.2013 Lecture: Bioinformatics in medicine – from molecules to populations 13th week: 13. – 17.5.2013 Lecture: Milestones in biological sciences in context with advances in clinical medicine 14th week: 20. – 24.5.2013 Lecture: Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the Year 2012“
Literature
    recommended literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009, 1 sv. ISBN 9780815341307. info
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • CAMPBELL, Neil A. Biology. Edited by Jane B. Reece. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005, xl, 1231. ISBN 080537146X. info
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics. 5th ed. Hoboken: John Wiley & Sons, Inc, 2009, xix, 823. ISBN 9780470388259. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012, xxviii, 79. ISBN 9780321709783. info
  • JANISCH, Roman. Overview of General Biology. 2. rozšířené. Brno: Masarykova univerzita, 2010, 91 pp. ISBN 978-80-210-5187-4. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd edition, Saunders 2007. ISBN: 978-1-4160-2255-8
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
Teaching methods
lecture
Assessment methods
written test - valid ICIS card is required to prove personal identity
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2012
Extent and Intensity
1/2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Hana Hříbková, Ph.D. (seminar tutor)
Mgr. Kateřina Vopěnková, Ph.D. (seminar tutor)
Eva Skalová (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 B11/114
  • Timetable of Seminar Groups:
ZLBI0222p/VLA: Wed 15:00–15:50 B11/234
Prerequisites (in Czech)
ZLBI0121c Biology I-pract. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent and modern concepts of developmental biology, cell signaling, structural and epigenetic changes in the DNA, gene therapy and bioinformatics are discussed. In addition, an introduction to tumor biology is included. The subject matter presented in this course will help to better understand other subjects including physiology, pathology and human and clinical genetics.
Syllabus
  • 1st week: 20. – 24.2.2012 Lecture: Introduction to developmental biology 2nd week: 27.2. – 2.3.2012 Lecture: Basic principles and molecular mechanisms regulating early development of mammals – physiology and pathology 3rd week: 5. – 9.3.2012 Lecture: Biology and use of stem cells in disease modelling and cell therapy 4th week: 12. – 16.3.2012 Lecture: Growth factors and signal transduction in development and disease 5th week: 19. – 23.3.2012 Lecture: Genome Instability- from molecular mechanisms of damage and DNA repair to clinical implications 6th week: 26. – 30.3.2012 Lecture: Molecular principle of genetic diseases 7th week: 2. – 6.4.2012 Lecture: Introduction to cancer biology 8th week: 9. – 13.4.2012 Lecture: Oncogenes and oncoviruses in cancer transformation 9th week: 16. – 20.4.2012 Lecture: Tumour supressor genes – implications for diagnostics and therapy 10th week: 22. – 26.4.2012 Lecture: Paradigm of cancer stem cells 11th week: 30.4. – 4.5.2012 Lecture: Objectives and strategies of molecular therapy 12th week: 7. – 11.5.2012 Lecture: Bioinformatics in medicine – from molecules to populations 13th week: 14. – 18.5.2012 Lecture: Milestones in biological sciences in context with advances in clinical medicine 14th week: 21. – 25.5.2012 Lecture: Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the Year 2011“
Literature
    recommended literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • ALBERTS, Bruce. Essential cell biology : an introduction to the molecular biology of the cell. New York: Garland Publishing, 1998, xxii, 630. ISBN 0-8153-2045-0. info
  • Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009, 1 sv. ISBN 9780815341307. info
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • CAMPBELL, Neil A. Biology. Edited by Jane B. Reece. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005, xl, 1231. ISBN 080537146X. info
  • PRITCHARD Dorian J. a B. R. KORF: Základy lékařské genetiky, 1. české vydání, Galén 2007. ISBN 978-80-7262-449-2
  • SNUSTAD D. Peter a Michael D. SIMMONS: Principles of Genetics, 5th edition, Wiley&Sons 2009. ISBN-13: 978-0-470-38825-9
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • JANISCH, Roman. Overview of General Biology. 2. rozšířené. Brno: Masarykova univerzita, 2010, 91 pp. ISBN 978-80-210-5187-4. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008, xxxvii, 11. ISBN 9780716776017. info
  • Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd edition, Saunders 2007. ISBN: 978-1-4160-2255-8
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
Teaching methods
lecture
Assessment methods
written test, the valid ICIS card is required to prove personal identity
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2011
Extent and Intensity
1/2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Hana Hříbková, Ph.D. (assistant)
Debora Ledahudcová (assistant)
Mgr. Lenka Paštěková, Ph.D. (assistant)
Ing. Lucia Ráheľová (assistant)
Eva Skalová (assistant)
Mgr. Kateřina Vopěnková, Ph.D. (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Martina Vráblíková
Timetable
Wed 9:30–10:20 B11/114
  • Timetable of Seminar Groups:
ZLBI0222p/40: Wed 15:00–15:50 B11/234
Prerequisites (in Czech)
ZLBI0121c Biology I-pract. && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent and modern concepts of developmental biology, cell signaling, structural and epigenetic changes in the DNA, gene therapy and bioinformatics are discussed. In addition, an introduction to tumor biology is included. The subject matter presented in this course will help to better understand other subjects including physiology, pathology and human and clinical genetics.
Syllabus
  • 1. week: 21. – 25.2. 2011 Lecture: Introduction to developmental biology (Prof. Ing. Petr Dvořák, CSc.) 2. week: 28.2. – 4.3.2011 Lecture: Basic principles and molecular mechanisms regulating early development of mammals – physiology and pathology (Prof. Ing. Petr Dvořák, CSc.) 3. week: 7. – 11. 3.2011 Lecture: Biology and use of stem cells in disease modelling and cell therapy (Prof. Ing. Petr Dvořák, CSc.) 4. week: 14. – 18. 3. 2011 Lecture: Growth factors and signal transduction in development and disease (Prof. Ing. Petr Dvořák, CSc. a Mgr. Pavel Krejčí, Ph.D.) 5. week: 21. – 25.3.2011 Lecture: Genome Instability- from molecular mechanisms of damage and DNA repair to clinical implications (Mgr. Lumír Krejčí, Ph.D) 6. week: 28.3. – 1. 4.2011 Lecture: Molecular principle of genetic diseases (Prof. MUDr. Marie Kopecká, CSc.) 7. week: 4. – 8. 4.2011 Lecture: Introduction to cancer biology (Mgr. Stjepan Uldrijan, CSc.) 8. week: 11. – 15. 4.2011 Lecture: Oncogenes and oncoviruses in cancer transformation (Mgr. Stjepan Uldrijan, CSc.) 9. week: 18. – 22. 4.2011 Lecture: Tumour supressor genes – implications for diagnostics and therapy (Mgr. Stjepan Uldrijan, CSc.) 10. week: 24. – 28. 4.2011 Lecture: Paradigm of cancer stem cells (Doc. MUDr. Iva Slaninová, Ph.D.) 11. week: 2. – 6. 5.2011 Lecture: Objectives and strategies of molecular therapy (Doc. MUDr. Iva Slaninová, Ph.D.) 12. week: 9. – 13. 5.2011 Lecture: Bioinformatics in medicine – from molecules to populations (Mgr. Vladimír Rotrekl, Ph.D.) 13. week: 16. – 20. 5.2011 Lecture: Milestones in biological sciences in context with advances in clinical medicine (Doc. MUDr. David Šmajs, Ph.D.) 14. week: 23. – 27.5.2011 Lecture: Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the Year 2010“
Literature
    recommended literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • Janisch R.: An overview of general biology, 2nd edition, Brno 2010. ISBN: 978-80-210-5187-4
  • LODISH, Harvey F. Molecular cell biology. 5th ed. New York: W.H. Freeman and Company, 2004, xxxiii, 97. ISBN 0-7167-4366-3. info
  • Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd edition, Saunders 2007. ISBN: 978-1-4160-2255-8
  • SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1st ed. Brno: Masarykova univerzita, 2009, 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
  • Snustad D. Peter, Simmons Michael D.: Principles of Genetics, 5th edition, Wiley&Sons 2009. ISBN-13: 978-0-470-38825-9
  • WOLPERT, L. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002, xxv, 542. ISBN 0198792913. info
Teaching methods
lecture
Assessment methods
written test, the valid ICIS card is required to prove personal identity
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2010
Extent and Intensity
1/2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Hana Hříbková, Ph.D. (assistant)
Debora Ledahudcová (assistant)
Mgr. Lenka Paštěková, Ph.D. (assistant)
Ing. Lucia Ráheľová (assistant)
Eva Skalová (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lucia Ráheľová
Timetable
Wed 9:40–10:30 KOM 200
  • Timetable of Seminar Groups:
ZLBI0222p/a: Wed 13:00–13:50 KOM 200
Prerequisites (in Czech)
ZLBI0121c Biology I - practice && ZC011 Handling chemical substances
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent and modern concepts of developmental biology, cell signaling, structural and epigenetic changes in the DNA, gene therapy and bioinformatics are discussed. In addition, an introduction to tumor biology is included. The subject matter presented in this course will help to better understand other subjects including physiology, pathology and human and clinical genetics.
Syllabus
  • Introduction to developmental biology, Molecular mechanisms of cell differentiation and death – relevance for cell pathologies, Basic principles and molecular mechanisms regulating early development of the mammals, Biology and use of stem cells, Growth factors and signal transduction, Introduction to cancer transformation, Structural DNA damage, epigenetic DNA modifications and repair mechanisms, Oncogenes and oncoviruses, Tumor supressor genes, Cancer stem cells, Gene therapy and biotherapeutics, Basics of bioinformatics, Milestones in biomedicine – some examples, Breakthrough of the year 2007 in molecular, cell or developmental biology with regard to biomedicine.
Literature
    recommended literature
  • Snustad D. Peter, Simmons Michael D.: Genetika (1.české vydání, přeloženo z Principles of Genetics), Nakladatelství Masarykovy univerzity 2009, 864 stran.
  • Snustad D. Peter, Simmons Michael D.: Principles of Genetics, 5th edition, Wiley&Sons, 2009.
  • Campbell, N., A., Reece, J., B. 2006 Biologie. Computer press (ISBN: 80-251-1178-4)
  • Alberts, B., et al..: Základy buněčné biologie: úvod do molekulární biologie buňky. Espero Publishing, Ústí nad Labem 2005, 740, ISBN-10: 80-902906-2-0
  • Lodish, H., Berk, A., Matsudaira, P., Kaiser,C.A., Krieger, M., Scott, M.P., Zipurski, L., Darnell, J.: Molecular Cell Biology 5th ed., 2004 (ISBN: 0-7167-4366-3)
  • Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd ed., Saunders-Elsevier, Philadelphia, 2008
  • Janish R.: An overview of general biology, 2nd expanded ed., Brno 2010
Teaching methods
lecture
Assessment methods
written test, the valid ICIS card is required to prove personal identity
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2009
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Hana Hříbková, Ph.D. (assistant)
Mgr. Petra Pospíšilová, Ph.D. (assistant)
Eva Skalová (assistant)
Debora Ledahudcová (assistant)
Ing. Lucia Ráheľová (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 KOM 200
Prerequisites (in Czech)
ZLBI0121c Biology I - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent and modern concepts of developmental biology, cell signaling, structural and epigenetic changes in the DNA, gene therapy and bioinformatics are discussed. In addition, an introduction to tumor biology is included. The subject matter presented in this course will help to better understand other subjects including physiology, pathology and human and clinical genetics.
Syllabus
  • Introduction to developmental biology, Molecular mechanisms of cell differentiation and death – relevance for cell pathologies, Basic principles and molecular mechanisms regulating early development of the mammals, Biology and use of stem cells, Growth factors and signal transduction, Introduction to cancer transformation, Structural DNA damage, epigenetic DNA modifications and repair mechanisms, Oncogenes and oncoviruses, Tumor supressor genes, Cancer stem cells, Gene therapy and biotherapeutics, Basics of bioinformatics, Milestones in biomedicine – some examples, Breakthrough of the year 2007 in molecular, cell or developmental biology with regard to biomedicine.
Literature
  • Snustad D. Peter, Simmons Michael D.: Genetika (1.české vydání, přeloženo z Principles of Genetics), Nakladatelství Masarykovy univerzity 2009, 864 stran.
  • Snustad D. Peter, Simmons Michael D.: Principles of Genetics, 5th edition, Wiley&Sons, 2009.
  • Campbell, N., A., Reece, J., B. 2006 Biologie. Computer press (ISBN: 80-251-1178-4)
  • Alberts, B., et al..: Základy buněčné biologie: úvod do molekulární biologie buňky. Espero Publishing, Ústí nad Labem 2005, 740, ISBN-10: 80-902906-2-0
  • Lodish, H., Berk, A., Matsudaira, P., Kaiser,C.A., Krieger, M., Scott, M.P., Zipurski, L., Darnell, J.: Molecular Cell Biology 5th ed., 2004 (ISBN: 0-7167-4366-3)
  • Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd ed., Saunders-Elsevier, Philadelphia, 2008
Assessment methods
Written test. The valid ICIS card is required to prove personal identity.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
http://www.med.muni.cz/biologie/Edu-under.htm
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2008
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
Mgr. Vítězslav Kříž, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
RNDr. Eva Horáčková (assistant)
Mgr. Hana Hříbková, Ph.D. (assistant)
Debora Ledahudcová (assistant)
Mgr. Petra Pospíšilová, Ph.D. (assistant)
Ing. Lucia Ráheľová (assistant)
Eva Skalová (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 KOM 200
Prerequisites (in Czech)
ZLBI0121c Biology I - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course affords current informations about molecular genetics and general genetics including practical aplications.
Syllabus
  • Introduction to developmental biology, Molecular mechanisms of cell differentiation and death – relevance for cell pathologies, Basic principles and molecular mechanisms regulating early development of the mammals, Biology and use of stem cells, Growth factors and signal transduction, Introduction to cancer transformation, Structural DNA damage, epigenetic DNA modifications and repair mechanisms, Oncogenes and oncoviruses, Tumor supressor genes, Cancer stem cells, Gene therapy and biotherapeutics, Basics of bioinformatics, Milestones in biomedicine – some examples, Breakthrough of the year 2007 in molecular, cell or developmental biology with regard to biomedicine.
Literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
Assessment methods (in Czech)
Písemná zkouška. Studenti mají povinnost přinést s sebou ke zkoušce platnou ISIC kartu pro ověření totožnosti. Written test. The valid ICIS card is required to prove personal identity.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
http://www.med.muni.cz/biologie/Edu-under.htm
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II-lecture

Faculty of Medicine
Spring 2007
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
Mgr. Vítězslav Kříž, Ph.D. (lecturer)
doc. RNDr. Jakub Neradil, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Eva Horáčková (assistant)
Mgr. Hana Hříbková, Ph.D. (assistant)
Debora Ledahudcová (assistant)
Vladimíra Ramíková (assistant)
Eva Skalová (assistant)
Guaranteed by
prof. MUDr. Augustin Svoboda, CSc., dr. h.c.
Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 9:30–10:20 KOM 200
Prerequisites (in Czech)
ZLBI0121c Biology I - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus (in Czech)
  • 1. TÝDEN: Přednáška: Genová terapie a bioterapeutika 2. TÝDEN: Přednáška: Molekulární mechanismy diferenciace buněk a poruchy buněčné diferenciace ve vztahu k patologickým procesům 3. TÝDEN: Přednáška: Úvod do vývojové biologie a časná vývojová determinace savčích embryí 4. TÝDEN: Přednáška: Základní principy a mechanismy vývoje a časné buněčné diferenciace 5. TÝDEN: Přednáška: Biologie a použití kmenových buněk 6. TÝDEN: Přednáška: Růstové faktory a signální transdukce 7. TÝDEN: Přednáška: Nádorová transformace, poruchy buněčného cyklu a nádorové buňky 8. TÝDEN: Přednáška: Kmenové buňky nádorů 9. TÝDEN: Přednáška: Mutace, poškození DNA a DNA repair 10. TÝDEN: Přednáška: Apoptóza ve fyziologických a patologických procesech 11. TÝDEN: Přednáška: Onkogeny, nádorové supresory a onkogenní viry 12. TÝDEN: Přednáška: Základy bioinformatiky 13. TÝDEN: Přednáška: Hlavní milestones v biomedicíně 1953-2000 14. TÝDEN: Přednáška: Aktuální téma molekulární, buněčné nebo vývojové biologie se vztahem k biomedicíně - breakthrough of the year
Assessment methods (in Czech)
Sylabus zkušební látky z biologie pro šk r. 2005/2006 Zubní lékařství I. MOLEKULÁRNÍ A BUNĚČNÁ BIOLOGIE 1. Biopolymery - struktura a analýza. Hiearchická struktura bílkovin čtyři úrovně popisu struktury bílkovinné molekuly. Primární struktura a sekundární struktura bílkovinné molekuly. Strukturální motivy. Terciární a kvarterní struktura bílkovinné molekuly: Strukturální a funkční domény. Skládání polypeptidického řetězce do nativní konformace bílkoviny Modifikace a degradace struktury bílkovin Sekvenční homologie proteinů a jejich význam v evoluci Elektroforetická separace proteinů: principy a využití. Struktura nativní molekuly DNA. Reversibilní změny struktury DNA. Struktura a konformace molekul RNA. Struktura a funkce molekul polysacharidů. Glykoproteiny 2. Obecná struktura buňky. Hierarchie živých soustav. Základní vlastnosti společné všem buňkám. Shody a rozdíly ve struktuře prokaryontní a eukaryontní buňky. Archea zvláštnosti struktury a funkce. Evoluční souvislosti prokaryontů, Archeí a eukaryontů. Struktura prokaryontní buňky. Bakteriální buněčná stěna. Bakteriální chromosom. Konjugace bakterií. Sinice Mykoplasmata. Rickettsie. Chlamydie 3. Membrány a funkční organizace buňky. Molekulární struktura biomembrán. Membránové fosfolipidy. Membránové proteiny. Uspořádání molekul v biomembránách. Fluidita biomembrán experimentální průkaz. Transport látek přes membránu. Volná difúze. Transmembránové proteinové kanály. Přenašečový transport. Membránové ATP-ázy. Plasmatická membrána a extracelulární matrix.. Adhezivní molekuly a integrace buněk do tkání. Buněčné spoje. Organely eukaryontní buňky: techniky izolace, strukturální a funkční charakteristika. Mitochondrie a chloroplasty: funkce membrán při transformaci chemické energie. Organely sekreční dráhy a endocytózy. 4. Genetická výbava buňky a exprese genetické informace. Historie objevu funkce DNA v dědičnosti. Genetická informace a pojem gen Geny strukturní, geny pro RNA. Negenová DNA. Metody studia genu: DNA elektroforéza. Sekvenční analýza. Restrikční analýza. Hybridizace DNA. Buněčný genom: Genofory prokaryontní a eukaryontní buňky Prokaryontní chromosom a jeho funkční součásti Eukaryontní chromosom a úrovně jeho molekulární organizace Změny histonů ve vztahu k funkčním projevům genu Lokalizace strukturních genů v chromosomu. Chromosomové mapy. Euchromatin a heterochromatin. Struktura buněčného jádra. Plasmidy. Pohyblivé elementy v genomu. Transkripce: Iniciace, elongace a terminace syntézy RNA. Transkripce v eukaryontní buňce. Reverzní transkripce. Posttranskripční modifikace tRNA, mRNA. Sestřih mRNA. Editace RNA. Prostorová organizace procesů odehrávajících se v jádře. Regulace exprese genetické informace u bakterií a eukaryont. Regulace exprese genu: úrovně regulace u eukaryont. (Metylace DNA, včleňování transpozonů, enhancery, silencery, transkripční faktory, alternativní sestřih) Genetický kód. Součásti translačního aparátu. Prokaryontní a eukaryontní ribosomy.. Iniciace, elongace a terminace proteosyntézy Lokalizace proteosyntézy v buňce. Syntéza proteinů na volných ribosomech. Syntéza proteinů na endoplasmatickém retikulu. Posttranslační modifikace proteinů. Degradace proteinů - proteasomy. Molekulární chaperony. Priony. Průkaz semikonzervativní replikace DNA. Molekulární mechanismus replikace: iniciace replikace, dynamika polymerace. Okazakiho fragmenty. Telomery a telomeráza. Inhibitory syntézy DNA, RNA a proteinů Šum v genetické informaci - mutace. Mutagenní faktory. Genové mutace - molekulární podstata. Důsledky mutace strukturních genů. Podmíněné mutace. Somatické a gametické mutace. Cílená mutageneze. Strukturní aberace chromosomů. Numerické aberace chromosomů. Technologie rekombinantní DNA. Klonování genů. DNA knihovny. Genové inženýrství. Transgenní organismy. Geneticky modifikované organismy Mechanizmy reparace mutací (DNA repair) 5. Cytoskelet a funkční organizace buňky. Cytoskelet: definice, strukturální elementy, metody studia. Struktura a funkce mikrotubulů. Mikrotubulární struktury buňky Struktura a funkce mikrofilament. Struktura a funkce středních filament. Proteiny asociované s cytoskeletem. Molekulární motory. Vnitrobuněčný transport. Améboidní pohyb. Pohyb kinocílií. 6. Reprodukce a zánik buněk. Buněčný cyklus a jeho fáze. Uzlové body buněčného cyklu a jejich experimentální průkaz Molekuly regulující buněčný cyklus: MPF, CDK, cykliny a inhibitory. Abnormality regulace buněčného cyklu zdroje a biomedicíncký význam. Regulace buněčného cyklu v mnohobuněčném organismu: Růstové faktory. Dráha mitogenního signálu. Mitotický aparát. Průběh mitózy Cytokineze. Diferenciace buněk. Genová kontrola diferenciace. Dediferenciace. Apoptóza a nekróza buňky Nádorová transformace buňky: Znaky nádorových buněk. Kontaktní inhibice. Protoonkogeny a kontrola buněčného cyklu. Onkogeny a tumor supresorové geny. Mechanizmy aktivace onkogenů. Onkogenní viry. Vznik a vývoj nádorů model kolorektálního karcinomu. 7. Buněčný stres. Odpověď buňky na stres. Stresové proteiny. Účinek jedů. Cytotoxiny, cytostatika. Molekulární patologie: Specifická inhibice syntézy nukleových kyselin a proteinů v experimentu. Inhibice funkcí a energetického metabolismu. Inhibitory buněčného růstu. Stárnutí buněk projevy a příčiny. Hayflickův limit. 8. Metody studia biologie buňky. Preparace buněk pro elektronovou mikroskopii. Interpretace obrázků z ELM. Buněčné kultury. Monoklonální protilátky ve studiu biologie buňky. .. II. BIOLOGIE VIRŮ Struktura virionů. Virový genom. RNA a DNA viry. Reprodukce virů. Lytický a lysogenní cyklus bakteriofága. Virogenie. LTR sekvence a exprese virového genomu. Retroviry. HIV virus. Cytopatologie interakce virus - buňka. III. ÚVOD DO VÝVOJOVÉ BIOLOGIE 1. Časná vývojová determinace savčích embryí Oplození cytologické a genetické aspekty. Aktivace a inaktivace chromosomových lokusů. Genová kontrola embryogeneze: Homeotické geny a homeoboxy. Modelové organismy vývojové biologie a jejich význam pro biomedicínu. Polarizace oplozených vajíček a časných embryí savců. Mechanismus embryonální indukce. Determinace tělní osy a levo-pravé asymetrie v embryích savců. Gastrulace jako první reorganizace embryonálních buněk. Mezibuněčné interakce během organogeneze a principy teratogeneze. Vývoj gamet u savců. 2. Biologie kmenových buněk. Definice a základní vlastnosti kmenových buněk. Embryonální kmenové buňky versus kmenové buňky v dospělém organismu rozdíly a podobnosti. Molekulární znaky kmenových buněk ve vztahu k jejich vlastnostem. Využití kmenových buněk ve vědě a medicíně příklady. Kmenové buňky nádorů. 3. Růstové faktory a signální transdukce. G-proteiny a přenos signálů. Proteinkinázy. cAMP a jeho role v signalizaci. Obecné biologické vlastnosti růstových faktorů a cytokinů. Signální receptory a koreceptory růstových faktorů struktura a příklady. Obecné principy signální transdukce. Jaderné receptory a percepce signálů v jádře Transkripční faktory a buněčná odpověď na exogenní stimulaci. IV. OBECNÉ ZÁKONITOSTI DĚDIČNOSTI 1. Vertikální přenos dědičné informace. Nepohlavní rozmnožování. Pohlavní rozmnožování a sexuální proces. Meióza versus mitóza. Genetické důsledky meiózy. Segregace chromosomů. Crossing-over - molekulární mechaniz-my Vývoj gamet procesy společné samčím a samičím gametám. Růst a meiotické zrání oocytu podstata a význam. Aktivace embryonálního genomu reprogramace jádra. Přenos jádra: biomedicíncké aplikace manipulací s vajíčkem. Oplození. Genové rekombinace v průběhu pohlavního rozmnožování. Chromosomová determinace pohlaví. Mitochondriální a plastidová dědičnost. Epigenní dědičnost. Podstata nedědičné variability. 2. Genová determinace znaků mnohobuněčného organismu. Biologický význam diploidie. Vztah mezi geny a znaky. Genotyp a fenotyp. Alely a mnohotná alelie Metody hybridologické analýzy. Homozygot a heterozygot. Dědičnost monogenních znaků. Dědičnost autosomální. Interakce párových alel. Dominance a recesivita. Letální kombinace alel. Dědičnost gonosomální. Dědičnost znaků pohlavně ovládaných a ovlivněných. Genová vazba. Konstrukce chromosomových map. Dědičnost polygenních znaků. Aditivní účinek alel. Pleiotropie. Polysomie. Vliv prostředí na hodnotu kvantitativních znaků. 3. Lidský genom: Základní cíle a metody projektu sekvenace lidského genomu. Struktura lidského genomu. Potenciální aplikace výzkumu lidského genomu. Schéma provedení sekvenace lidského genomu. 4. Genetika člověka. Charakteristika lidského karyotypu. Mapy lidských chromosomů. Genová a negenová determinace znaků člověka. Heritabilita. Podstata genetické a fenotypové jedinečnosti lidského jedince. Dědičnost morfologických a biochemických znaků u člověka. Polygenní dědičnost u člověka. Expresivita a penetrance. Mendelovský typ dědičnosti patologických znaků člověka. Geny heterochromosomů. Dědičnost krevních skupin.. Příklady hemoglobinopatií. Hemofilie. Příklady dědičných metabolických vad. Strukturální a numerické aberace lidských chromosomů. Genová diagnostika. Genová terapie strategie, vektory, kandidátní choroby, současná praxe. Přehled vektorů vhodných pro genovou terapii (terapeutické vektory) přehled, virové vektory. Využití rekombinantních proteinů a malých biologicky aktivních molekul v terapii. Rizika a etické problémy genové terapie. Genový drift. Balancovaný polymorfizmus. 5. Přehled metod studia dědičnosti. Genové sondy. Restrikční endonukleázy. Restrikční mapování Metody chromosomového mapování. Pruhování chromosomů. Možnosti lékařské cytogenetiky. Gemelilogická metoda. Genealogická metoda. Konvenční genová symbolika. Metody pro zjištění heterozygotů Principy DNA diagnostiky. Modelové úlohy z genetické prognózy Hardyho - Weinbergova genetická rovnováha: důsledky a uplatnění Využití metod genového inženýrství v lékařství. V. EVOLUCE ŽIVÝCH SOUSTAV 1. Mechanismy evoluce živých soustav. Podstata Darwinovy teorie. Pojem druh. Vznik druhů - mechanizmy speciace. 2. Vývoj člověka. Genové vzdálenosti mezi člověkem a ostatními primáty
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II-lecture

Faculty of Medicine
Spring 2006
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
prof. MUDr. Marie Kopecká, CSc. (lecturer)
doc. RNDr. Jakub Neradil, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Hana Hříbková, Ph.D. (assistant)
Debora Ledahudcová (assistant)
Eva Skalová (assistant)
RNDr. Markéta Unucková, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Augustin Svoboda, CSc., dr. h.c.
Department of Biology – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
ZLBI0121c Biology I-pract.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus (in Czech)
  • 1. TÝDEN: Přednáška: Genová terapie a bioterapeutika 2. TÝDEN: Přednáška: Molekulární mechanismy diferenciace buněk a poruchy buněčné diferenciace ve vztahu k patologickým procesům 3. TÝDEN: Přednáška: Úvod do vývojové biologie a časná vývojová determinace savčích embryí 4. TÝDEN: Přednáška: Základní principy a mechanismy vývoje a časné buněčné diferenciace 5. TÝDEN: Přednáška: Biologie a použití kmenových buněk 6. TÝDEN: Přednáška: Růstové faktory a signální transdukce 7. TÝDEN: Přednáška: Nádorová transformace, poruchy buněčného cyklu a nádorové buňky 8. TÝDEN: Přednáška: Kmenové buňky nádorů 9. TÝDEN: Přednáška: Mutace, poškození DNA a DNA repair 10. TÝDEN: Přednáška: Apoptóza ve fyziologických a patologických procesech 11. TÝDEN: Přednáška: Onkogeny, nádorové supresory a onkogenní viry 12. TÝDEN: Přednáška: Základy bioinformatiky 13. TÝDEN: Přednáška: Hlavní milestones v biomedicíně 1953-2000 14. TÝDEN: Přednáška: Aktuální téma molekulární, buněčné nebo vývojové biologie se vztahem k biomedicíně - breakthrough of the year
Assessment methods (in Czech)
Sylabus zkušební látky z biologie pro šk r. 2005/2006 Zubní lékařství I. MOLEKULÁRNÍ A BUNĚČNÁ BIOLOGIE 1. Biopolymery - struktura a analýza. Hiearchická struktura bílkovin čtyři úrovně popisu struktury bílkovinné molekuly. Primární struktura a sekundární struktura bílkovinné molekuly. Strukturální motivy. Terciární a kvarterní struktura bílkovinné molekuly: Strukturální a funkční domény. Skládání polypeptidického řetězce do nativní konformace bílkoviny Modifikace a degradace struktury bílkovin Sekvenční homologie proteinů a jejich význam v evoluci Elektroforetická separace proteinů: principy a využití. Struktura nativní molekuly DNA. Reversibilní změny struktury DNA. Struktura a konformace molekul RNA. Struktura a funkce molekul polysacharidů. Glykoproteiny 2. Obecná struktura buňky. Hierarchie živých soustav. Základní vlastnosti společné všem buňkám. Shody a rozdíly ve struktuře prokaryontní a eukaryontní buňky. Archea zvláštnosti struktury a funkce. Evoluční souvislosti prokaryontů, Archeí a eukaryontů. Struktura prokaryontní buňky. Bakteriální buněčná stěna. Bakteriální chromosom. Konjugace bakterií. Sinice Mykoplasmata. Rickettsie. Chlamydie 3. Membrány a funkční organizace buňky. Molekulární struktura biomembrán. Membránové fosfolipidy. Membránové proteiny. Uspořádání molekul v biomembránách. Fluidita biomembrán experimentální průkaz. Transport látek přes membránu. Volná difúze. Transmembránové proteinové kanály. Přenašečový transport. Membránové ATP-ázy. Plasmatická membrána a extracelulární matrix.. Adhezivní molekuly a integrace buněk do tkání. Buněčné spoje. Organely eukaryontní buňky: techniky izolace, strukturální a funkční charakteristika. Mitochondrie a chloroplasty: funkce membrán při transformaci chemické energie. Organely sekreční dráhy a endocytózy. 4. Genetická výbava buňky a exprese genetické informace. Historie objevu funkce DNA v dědičnosti. Genetická informace a pojem gen Geny strukturní, geny pro RNA. Negenová DNA. Metody studia genu: DNA elektroforéza. Sekvenční analýza. Restrikční analýza. Hybridizace DNA. Buněčný genom: Genofory prokaryontní a eukaryontní buňky Prokaryontní chromosom a jeho funkční součásti Eukaryontní chromosom a úrovně jeho molekulární organizace Změny histonů ve vztahu k funkčním projevům genu Lokalizace strukturních genů v chromosomu. Chromosomové mapy. Euchromatin a heterochromatin. Struktura buněčného jádra. Plasmidy. Pohyblivé elementy v genomu. Transkripce: Iniciace, elongace a terminace syntézy RNA. Transkripce v eukaryontní buňce. Reverzní transkripce. Posttranskripční modifikace tRNA, mRNA. Sestřih mRNA. Editace RNA. Prostorová organizace procesů odehrávajících se v jádře. Regulace exprese genetické informace u bakterií a eukaryont. Regulace exprese genu: úrovně regulace u eukaryont. (Metylace DNA, včleňování transpozonů, enhancery, silencery, transkripční faktory, alternativní sestřih) Genetický kód. Součásti translačního aparátu. Prokaryontní a eukaryontní ribosomy.. Iniciace, elongace a terminace proteosyntézy Lokalizace proteosyntézy v buňce. Syntéza proteinů na volných ribosomech. Syntéza proteinů na endoplasmatickém retikulu. Posttranslační modifikace proteinů. Degradace proteinů - proteasomy. Molekulární chaperony. Priony. Průkaz semikonzervativní replikace DNA. Molekulární mechanismus replikace: iniciace replikace, dynamika polymerace. Okazakiho fragmenty. Telomery a telomeráza. Inhibitory syntézy DNA, RNA a proteinů Šum v genetické informaci - mutace. Mutagenní faktory. Genové mutace - molekulární podstata. Důsledky mutace strukturních genů. Podmíněné mutace. Somatické a gametické mutace. Cílená mutageneze. Strukturní aberace chromosomů. Numerické aberace chromosomů. Technologie rekombinantní DNA. Klonování genů. DNA knihovny. Genové inženýrství. Transgenní organismy. Geneticky modifikované organismy Mechanizmy reparace mutací (DNA repair) 5. Cytoskelet a funkční organizace buňky. Cytoskelet: definice, strukturální elementy, metody studia. Struktura a funkce mikrotubulů. Mikrotubulární struktury buňky Struktura a funkce mikrofilament. Struktura a funkce středních filament. Proteiny asociované s cytoskeletem. Molekulární motory. Vnitrobuněčný transport. Améboidní pohyb. Pohyb kinocílií. 6. Reprodukce a zánik buněk. Buněčný cyklus a jeho fáze. Uzlové body buněčného cyklu a jejich experimentální průkaz Molekuly regulující buněčný cyklus: MPF, CDK, cykliny a inhibitory. Abnormality regulace buněčného cyklu zdroje a biomedicíncký význam. Regulace buněčného cyklu v mnohobuněčném organismu: Růstové faktory. Dráha mitogenního signálu. Mitotický aparát. Průběh mitózy Cytokineze. Diferenciace buněk. Genová kontrola diferenciace. Dediferenciace. Apoptóza a nekróza buňky Nádorová transformace buňky: Znaky nádorových buněk. Kontaktní inhibice. Protoonkogeny a kontrola buněčného cyklu. Onkogeny a tumor supresorové geny. Mechanizmy aktivace onkogenů. Onkogenní viry. Vznik a vývoj nádorů model kolorektálního karcinomu. 7. Buněčný stres. Odpověď buňky na stres. Stresové proteiny. Účinek jedů. Cytotoxiny, cytostatika. Molekulární patologie: Specifická inhibice syntézy nukleových kyselin a proteinů v experimentu. Inhibice funkcí a energetického metabolismu. Inhibitory buněčného růstu. Stárnutí buněk projevy a příčiny. Hayflickův limit. 8. Metody studia biologie buňky. Preparace buněk pro elektronovou mikroskopii. Interpretace obrázků z ELM. Buněčné kultury. Monoklonální protilátky ve studiu biologie buňky. .. II. BIOLOGIE VIRŮ Struktura virionů. Virový genom. RNA a DNA viry. Reprodukce virů. Lytický a lysogenní cyklus bakteriofága. Virogenie. LTR sekvence a exprese virového genomu. Retroviry. HIV virus. Cytopatologie interakce virus - buňka. III. ÚVOD DO VÝVOJOVÉ BIOLOGIE 1. Časná vývojová determinace savčích embryí Oplození cytologické a genetické aspekty. Aktivace a inaktivace chromosomových lokusů. Genová kontrola embryogeneze: Homeotické geny a homeoboxy. Modelové organismy vývojové biologie a jejich význam pro biomedicínu. Polarizace oplozených vajíček a časných embryí savců. Mechanismus embryonální indukce. Determinace tělní osy a levo-pravé asymetrie v embryích savců. Gastrulace jako první reorganizace embryonálních buněk. Mezibuněčné interakce během organogeneze a principy teratogeneze. Vývoj gamet u savců. 2. Biologie kmenových buněk. Definice a základní vlastnosti kmenových buněk. Embryonální kmenové buňky versus kmenové buňky v dospělém organismu rozdíly a podobnosti. Molekulární znaky kmenových buněk ve vztahu k jejich vlastnostem. Využití kmenových buněk ve vědě a medicíně příklady. Kmenové buňky nádorů. 3. Růstové faktory a signální transdukce. G-proteiny a přenos signálů. Proteinkinázy. cAMP a jeho role v signalizaci. Obecné biologické vlastnosti růstových faktorů a cytokinů. Signální receptory a koreceptory růstových faktorů struktura a příklady. Obecné principy signální transdukce. Jaderné receptory a percepce signálů v jádře Transkripční faktory a buněčná odpověď na exogenní stimulaci. IV. OBECNÉ ZÁKONITOSTI DĚDIČNOSTI 1. Vertikální přenos dědičné informace. Nepohlavní rozmnožování. Pohlavní rozmnožování a sexuální proces. Meióza versus mitóza. Genetické důsledky meiózy. Segregace chromosomů. Crossing-over - molekulární mechaniz-my Vývoj gamet procesy společné samčím a samičím gametám. Růst a meiotické zrání oocytu podstata a význam. Aktivace embryonálního genomu reprogramace jádra. Přenos jádra: biomedicíncké aplikace manipulací s vajíčkem. Oplození. Genové rekombinace v průběhu pohlavního rozmnožování. Chromosomová determinace pohlaví. Mitochondriální a plastidová dědičnost. Epigenní dědičnost. Podstata nedědičné variability. 2. Genová determinace znaků mnohobuněčného organismu. Biologický význam diploidie. Vztah mezi geny a znaky. Genotyp a fenotyp. Alely a mnohotná alelie Metody hybridologické analýzy. Homozygot a heterozygot. Dědičnost monogenních znaků. Dědičnost autosomální. Interakce párových alel. Dominance a recesivita. Letální kombinace alel. Dědičnost gonosomální. Dědičnost znaků pohlavně ovládaných a ovlivněných. Genová vazba. Konstrukce chromosomových map. Dědičnost polygenních znaků. Aditivní účinek alel. Pleiotropie. Polysomie. Vliv prostředí na hodnotu kvantitativních znaků. 3. Lidský genom: Základní cíle a metody projektu sekvenace lidského genomu. Struktura lidského genomu. Potenciální aplikace výzkumu lidského genomu. Schéma provedení sekvenace lidského genomu. 4. Genetika člověka. Charakteristika lidského karyotypu. Mapy lidských chromosomů. Genová a negenová determinace znaků člověka. Heritabilita. Podstata genetické a fenotypové jedinečnosti lidského jedince. Dědičnost morfologických a biochemických znaků u člověka. Polygenní dědičnost u člověka. Expresivita a penetrance. Mendelovský typ dědičnosti patologických znaků člověka. Geny heterochromosomů. Dědičnost krevních skupin.. Příklady hemoglobinopatií. Hemofilie. Příklady dědičných metabolických vad. Strukturální a numerické aberace lidských chromosomů. Genová diagnostika. Genová terapie strategie, vektory, kandidátní choroby, současná praxe. Přehled vektorů vhodných pro genovou terapii (terapeutické vektory) přehled, virové vektory. Využití rekombinantních proteinů a malých biologicky aktivních molekul v terapii. Rizika a etické problémy genové terapie. Genový drift. Balancovaný polymorfizmus. 5. Přehled metod studia dědičnosti. Genové sondy. Restrikční endonukleázy. Restrikční mapování Metody chromosomového mapování. Pruhování chromosomů. Možnosti lékařské cytogenetiky. Gemelilogická metoda. Genealogická metoda. Konvenční genová symbolika. Metody pro zjištění heterozygotů Principy DNA diagnostiky. Modelové úlohy z genetické prognózy Hardyho - Weinbergova genetická rovnováha: důsledky a uplatnění Využití metod genového inženýrství v lékařství. V. EVOLUCE ŽIVÝCH SOUSTAV 1. Mechanismy evoluce živých soustav. Podstata Darwinovy teorie. Pojem druh. Vznik druhů - mechanizmy speciace. 2. Vývoj člověka. Genové vzdálenosti mezi člověkem a ostatními primáty
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2005, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

ZLBI0222p Biology II-lecture

Faculty of Medicine
Spring 2005
Extent and Intensity
1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Debora Ledahudcová (assistant)
Guaranteed by
prof. MUDr. Augustin Svoboda, CSc., dr. h.c.
Department of Biology – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
ZLBI0121c Biology I - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
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