ZLBC0321p Biochemisty I - lecture

Faculty of Medicine
autumn 2024
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
ZLLC011p Med Chem, Dent Mat - lect && ZLBF0222p Med.Physics and Inf. II - lect && ZLBI0222p Biology II-lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to introduce students to the basic metabolic pathways and processes occurring at the cellular level in the human organism.
Learning outcomes
Upon completion of the course, student will be able to:
- understand the meaning of basic chemical concepts and apply them in describing biochemical processes in an organism.
- discuss the properties and functions of enzymes.
- describe the basic catabolic and anabolic pathways of cellular metabolism of carbohydrates, lipids, and proteins.
- characterize the principles of energy acquisition, utilization, and storage in the cell.
- explain protein synthesis, beginning with the processes of replication and transcription, including posttranslational modifications.
- understand the relationship between the structure and function of proteins, e.g. haemoglobin, collagen, elastin.
- characterize the causes of some diseases at the molecular level.
Syllabus
  • Enzymes. Cofactors.
  • Citrate cycle. Respiratory chain. Oxidative phosphorylation.
  • Carbohydrates. Glycolysis. Gluconeogenesis. Metabolism of glycogen, fructose, galactose. The pentose phosphate pathway.
  • Lipids and fatty acids. Metabolism of fatty acids, ketone bodies, triacylglycerols, glycerophospholipids.
  • Lipoperoxidation. Eicosanoids. Metabolism of cholesterol, bile acids.
  • Protein degradation. General features in catabolism of amino acids. Ammonia detoxification and transport. Amino acid metabolism.
  • Heme synthesis. Hemoglobin, myoglobin.
  • Metabolism of purine/pyrimidine nucleotides.
  • Replication, transcription and its regulation, post-transcriptional modifications.
  • Protein synthesis, post-translational modification.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, Strana 275. ISBN 9788024647494. info
    recommended literature
  • FERRIER, Denise R. Lippincott's illustrated Q&A review of biochemistry. Seventh edition. Wolters Kluwer, 2017. ISBN 9781496344496. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017, xiii, 289. ISBN 9789352701148. info
Teaching methods
Přednášky.
Assessment methods
Credit, no knowledge testing.
The course is followed in the 4th semester by Biochemistry II. The content of Biochemistry I is included in the Biochemistry II exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
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