aZLFA0621p Farmakologie I - přednáška

Lékařská fakulta
jaro 2027
Rozsah
1/0/0. 15. 1 kr. Ukončení: z.
Vyučováno kontaktně
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (přednášející)
doc. PharmDr. Jan Juřica, Ph.D. (přednášející)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (přednášející)
Carlos Daniel Ferreira Fonseca, MSc. (přednášející)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Předpoklady
aZLPA0521c Patologie I - cvičení && aZLPF0521c Patol. fyziologie I - cv. && aZLCP051c Chirurgická propedeutika -cv.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
The course provides dental students with information necessary for their clinical practice in the field of general pharmacology and selected topics in special pharmacology.
Výstupy z učení
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Klíčová témata

  • LECTURES

  • Spring semester 

  • 1. INTRODUCTION TO THE STUDY OF PHARMACOLOGY, LIFE CYCLE OF DRUGS
  • Definitions and basic terminology in pharmacology, subbranches. Classification and names of drugs. Types of pharmacotherapy, rational pharmacotherapy, legislation and regulation related to medicines. Safety of medicines, types of doses. Life cycle of medicines.
  • 2. BASIC PHARMACOKINETICS AND PHARMACODYNAMICS
  • General principles of drug movement in the organism. Absorption, distribution, biotransformation, excretion. Basic pharmacokinetic parameters. Specific and non-specific mechanisms of drug action. Receptor theory.
  • 3. DRUG SAFETY, FACTORS INFLUENCING DRUG ACTION
  • Classification and characteristics of adverse drug reactions. Pharmacovigilance in clinical practice, sources of current information on drug safety. Classification, overview and examples of factors influencing drug action. Basics of pharmacogenetics. Classification of drug interactions. Pharmacotherapy in childhood, pregnancy, lactation, old age
  • 4. INTRODUCTION TO THE PHARMACOLOGY OF ANS
  • Introduction to the pharmacology of sympathetic and parasympathetic nervous systems - neurotransmission, receptors. Overview and basic pharmacological characteristics of drugs affecting sympathetic and parasympathetic activity.
  • 5. PHARMACOLOGICALLY USED HORMONES
  • Estrogens, antiestrogens, gestagens, antigestagens, androgens, antiandrogens - basic pharmacological charachteristics. Hormonal contraceptives. Drugs used in the therapy of thyroid diseases and affecting bone metabolism. Overview of glucocorticoids and their therapeutic use.
  • 6. PHARMACOLOGY OF THE GASTROINTESTINAL TRACT, PHARMACOLOGY OF HISTAMINE
  • Drugs influencing GIT – laxatives, antidiarrhoics, antiemetics, antiulcer agents. Classification and overview of H1-antihistamines.
  • 7. ANTIDIABETICS, INSULINS
  • Classification, therapeutic use and basic pharmacological charachteristics
  • 8. BASICS OF BIOLOGICAL THERAPY 
  • Principles of biological therapy, examples of drugs and their use, pharmacokinetics of monoclonal antibodies, specific side effects of biologics.



Studijní zdroje a literatura
    povinná literatura
  • RITTER, James; R. J. FLOWER; Graeme HENDERSON; Yoon Kong LOKE; David J. MACEWAN a H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier, 2020, xvi, 789. ISBN 9780702074486. info
  • Selected chapters from general pharmacology for students of general medicine and dentistry at FM MU, https://portal.med.muni.cz/discipline-13-pharmacology
    doporučená literatura
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    neurčeno
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
Přístupy, postupy a metody používané ve výuce
Teaching is in the form of lecture records available in the IS. Students can discuss the topic with the lecturer via the discussion thread in the IS or the following practical lessons.
Způsob ověření výstupů z učení a požadavky na ukončení
Knowledge is assessed through a series of tests in the course aZLFA0621c. The same rules apply to completing this course as to completing aZLFA0621c.
Náhradní absolvování
The course cannot be completed in an alternative form. In the event of long-term illness or an internship abroad, please contact the course coordinator.
Vyučovací jazyk
Angličtina
Navazující předměty
Odkaz a informace vyučujících
https://is.muni.cz/auth/el/1411/jaro2027/aZLFA0621p/

In the spring semester, the course is completed with credit. After receiving credit, students move on to continuing education in the next semester without having to test their knowledge in that semester. Further assessment conditions in the follow-up course are published for students under the course code cZLFA0621c.

The lecture recording and discussion thread for each lecture is embedded within the interactive syllabus in IS.
Studijní opora
https://is.muni.cz/auth/el/1411/jaro2027/aZLFA0621p/
Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá každý týden.
Předmět je zařazen také v obdobích jaro 2018, jaro 2019, jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024, jaro 2025, jaro 2026.