ZLFA0722p Pharmacology II - lecture

Faculty of Medicine
autumn 2020
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Mgr. Mária Hricková (alternate examiner)
Filip Šiška (alternate examiner)
PharmDr. Eva Vohlídalová (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Timetable
Tue 6. 10. 14:00–15:40 B11/334, Tue 13. 10. 14:00–15:40 B11/334, Tue 20. 10. 14:00–15:40 B11/334, Tue 27. 10. 14:00–15:40 B11/334, Tue 3. 11. 14:00–15:40 B11/334, Tue 10. 11. 14:00–15:40 B11/334, Tue 24. 11. 14:00–15:40 B11/334
Prerequisites (in Czech)
ZLFA0621c Pharmacology I - pract. && ZLPA0622c Pathology II - practice && ZLPF0622c Pathophys. II - practice && ZLOR0641c Orthodontics I -pract. && ZLPD0631c Periodontology I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student will be oriented in drug classes according to their main therapeutic indications, in pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions. The student will be able to judge pharmacoeconomic analyses for pharmacotherapy used in practice.
Learning outcomes
At the end of the course student will be oriented in drug classes according to their main therapeutic indications, in pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions. The student will be able to judge pharmacoeconomic analyses for pharmacotherapy used in practice.
Syllabus
  • Lectures - PS 2020
  • 1. Basics of pharmacotherapy of cardiovascular diseases.
  • 2. Introduction to psychopharmacology. Antipsychotics - mechanisms of action, side effects.
  • 3. Antidepressants - mechanisms of action, side effects.
  • 4. Pharmacotherapy of peptic ulcer disease. Antiemetics. Mechanisms of action, side effects.
  • 5. Cytostatics. Principles of targeted treatment in oncology, monoclonal antibodies, tyrosine kinase inhibitors, use in the therapy of selected diseases.
  • 6. Disinfectants and antiseptics with a focus on dentistry. Mechanisms of action, side effects.
  • 7. Bank holiday.
  • 8. Antimycotics with a focus on dentistry. Mechanisms of action, side effects.
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
    recommended literature
  • RANG, H. P. Rang & Dale's pharmacology. 9th ed. [Edinburgh]: Churchill Livingstone, 2019. xv, 808. ISBN 9780702074479
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů :: Portál Lékařské fakulty Masarykovy
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • Markova farmakoterapie vnitřních nemocí. Edited by Josef Marek - Michal Vrablík. 5., zcela přepracované a d. Praha: Grada, 2019. xxiv, 868. ISBN 9788024750781. info
  • Demlová Regina, Říhová Barbora, Grycová Zuzana, Nerušilová Kateř. Životní cyklus léčiv. MASARYKOVA UNIVERZITA LÉKAŘSKÁ FAKULTA, 2014. URL info
  • Náhradní obsah: Základy receptury léčivých přípravků. Nováková a kol., 2010, http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
    not specified
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
  • Farmakologie pro studenty bakalářských oborů na LF MU, Máchalová a kol., 2015, http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • Lippincott's Illustrated Reviews : Pharmacology, 4th Ed., Harvey, Richard A. - Champe, Pamela C. - Finkel, Richard - Cubeddu, Luigi - Clarke, Michelle A. 2008. 560 s. ISBN-10: 0-7817-7155-2, ISBN-13: 978-0-7817-7155-9
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
Teaching methods
In the fall semester of 2020, teaching is governed by faculty traffic lights. Lectures led by a renowned teacher will be held online, synchronously with the syllabus. At the same time, a lecture with an audio track will be recorded. At the end of the lecture, space will be given for additional questions from students. MS TEAMS platform (event. another platform) will be used.
Assessment methods
The final exam is guided by the test (the answers to multiple-choice questions, the test contains 50 questions randomly generated for individual student). The minimum for passing the exam is to achieve: 30 points. Classification of marks according to achieved points: <30p. = F 30p. - 33p. = E 34p. - 37p. = D 38p. - 41p. = C 42p. - 45p. = B 46p. - 50p. = A
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
Information for the students studying in English:

In the fall semester of 2020, teaching is governed by faculty traffic lights. Lectures will be held online, synchronously with the syllabus. At the same time, a lecture with an audio track will be recorded. At the end of the lecture, space will be given for additional questions from students. MS TEAMS (event. different) platform will be used.

Workplace address: LF MU Pharmacology Institute, UKB, Kamenice 5, Pavilion A19.

Official secretariat hours daily 1 p.m. - 2 p.m., tel.: 54949 3070.

SYLABUS REQUIRED TOPICS TO PASS EXAM ON PHARMACOLOGY

EXAMPLES OF QUESTIONS ON GENERAL PHARMACOLOGICAL PRINCIPLES:

Routes of administration - overview, characteristics

Basic pharmacokinetic parameters and processes (overview)

Drug absorption, "first pass" effect

Biovailability of drugs

Drug distribution, volume of distribution

Drug elimination

Drug biotransformation, phases of biotransformation

Effect of environment pH and pKa of drugs on the drug transfer across biological membranes

Enzyme inhibition and induction

Drug excretion

Pharmacokinetics of single, repeated and continous drug administration

Pharmacokinetics of drug oral and parenteral administration

Drug dosage forms - overview and influence on pharmacokinetics

Therapeutic drug monitoring

Dose and effect, types of doses

Pharmacogenetics, pharmacogenetic polymorphism

Mechanisms of drug action - overview, non specific mechanisms of drug action

Specific mechanisms of drug action - the target structures, on which the drug act

Adverse drug reactions (types, categories)

Drug receptors theory - types of receptors

Tolerance, tachyphylaxis

Drug addiction

Therapeutic index, therapeutic range

Influence of concomitant diseases on drug effect, polypragmasia

Drug allergy (hypersensitivity), idiosyncrasy

Drug interactions- overview, pharmacokinetic interactions

Drug interactions- overview, pharmacodynamic interactions

Factors influencing the drug effect (related to drug, related to organism)

Pharmacoterapy in pregnancy, drug teratogenicity

Pharmacotherapy in breastfeeding women, in pediatric population

Pharmacoterapy in elderly

Pharmacology, sub-branches, origin of drugs, drug names

Pharmacopoeia

Rational pharmacotherapy, drug anamnesis, compliance

Development of a new drug (Drug life cycle)

Preclinical and clinical evaluation of drugs

Pharmacovigilance

General principles of drug poisoning therapy, specific antidotes and their mechanisms of action

Principles of biological therapy - technology, requirements on the quality, registration, biosimilars

EXAMPLES OF QUESTIONS ON "DRUG CLASSES":

Antimycotics

Antivirotics

Drugs with the topic action used in stomatology - overview

Antiinfective drugs used in stomatology

Disinfectants and antiseptics

Drugs with the topic action - dermatologics, drugs used in ORL

Principles of antibiotic therapy - overview, mechanisms of action, resistance

Antibiotics for topic use

Penicillines

Cephalosporins and other beta-lactams

Aminoglycosides

Macrolides

Sulphonamides

Tetracyclines

Quinolones and nitroimidazoles

Non-steroidal antiinflammatory drugs + Analgesics - antipyretics

Drugs used in gout

General anaesthetics

Premedications and supplement general anaesthesia, analgosedation, neuroleptanalgesia

Central and peripheral myorelaxants

Ester-type local anaesthetics

Amide-type local anaesthetics

Types and techniques of local anaesthesia

Pharmacoterapy of anaphylactic shock

Antitussives, expectorants

Hypolipidemics, lipid-lowering drugs

Drugs used in heart failure

Histamine H1-blockers

Antiasthmatics

Antihypertensives - overview + ACE inhibitors, sartans, renine antagonists

Antihypertensives - overview + diuretics, alpha1-lytics

Antihypertensives - overview + beta-blockers, central antihypertensives

Antiulcer drugs

Laxatives, antidiarrhoics

Antiemetics, prokinetics

Spasmolytics, digestives

Vitamins AEDK

Hydrophilic vitamins

Psychopharmacs - overview, classification

Hypnosedatives

Antiepileptic drugs

Antipsychotics

Anxiolytics

Antidepressants

Nootropics, drugs affecting cognitive functions

Psychostimulants, hallucinogenic and delirogenic drugs

Antidysrhytmics

Cardiotonics, inotropic drugs

Alkylating cytostatics and other impacts of DNA

Antimetabolites + hormonal therapy in oncology

Bilogical treatment in oncology

Glucocorticoids

Thyroid + anti-thyroid drugs

Drugs used in osteoporosis

Sex hormones - HRT, contraceptives

Uterotonics, tocolytics

Insulins

Antidiabetics for the treatment of type 2 DM

Anticoagulants, antiplatelet drugs

Antithrombotics, trombolytics

Opioid analgesics

Drugs causing addiction and pharmacological possibilities of addiction treatment

Drugs affecting ANS - neurotransmission, receptors of ANS, basic overview

Sympathomimetic agents - basic effects and classification - direct sympathomimetics

Sympathomimetic agents - basic effects and classification - indirect sympathomimetics

Sympatholytic agents - basic effects and classification - direct sympatholytics

Sympatholytic agents - basic effects and classification - indirect sympatholytics

Cholinomimetic agents - basic effects and classification - direct cholinomimetics

Cholinomimetic agents - basic effects and classification - indirect cholinomimetics

Cholinolytic agents - basic effects and classification - direct cholinolytics (parasympatholytics, ganglioplegics)

LIST OF GENERIC NAMES –„ESSENTIAL DRUGS“:

pantoprazole

famotidine

atropine

butylscopolamine

fenpiverine, pitofenone

metoclopramide

ondansetron

lactulose

insulin lispro

metformin

glibenclamide

warfarin

enoxaparin

acetylsalicylic acid

digoxin

propafenone

amiodarone

adrenaline

noradrenaline

dopamine

ephedrine, pseudoephedrine

nitroglycerin

methyldopa

clonidine

urapidil

hydrochlorothiazide

furosemide

metoprolol

labetalol

nifedipine

verapamil

enalapril

losartan

atorvastatin

ezetimibe

nystatin

ketoconazole

methylergometrine

hexoprenaline

alfuzosin

oxytocin

dexamethasone

prednisone

doxycycline, chloramphenicol

amoxicillin

phenoxymethylpenicillin

oxacillin

piperacillin, co-piperacillin

cefuroxime

cotrimoxazole

clarithromycin

gentamicin

ciprofloxacin

fluconazole

aciclovir

zidovudine

cyclophosphamide

methotrexate

6-mercaptopurine

5-fluorouracil

paclitaxel

doxorubicin

cisplatin

trastuzumab

tamoxifen

interferon alpha

ibuprofen

diclofenac

indomethacin

nimesulide

suxamethonium

allopurinol

alendronic acid

lidocaine

procaine

trimecaine

articaine

sevoflurane

thiopental

propofol

dihydrocodeine

sufentanil

piritramide

tramadol

paracetamol (acetaminophen)

metamizole

sumatriptan

valproic acid

gabapentin

haloperidol

risperidone

olanzapine

lithium

diazepam

alprazolam

zolpidem

midazolam

escitalopram

amitriptyline

bupropion

methylphenidate

donepezil

physostigmine

methadone

buprenorphine

betahistine

oxymetazoline, xylometazoline

phenylephrine

salbutamol

fenoterol

ipratropium bromide

nedocromil

acetylcysteine

bromhexine

codeine

butamirate

bisulepine

cetirizine

desloratadine

pilocarpine

timolol

tropicamide

The course is also listed under the following terms Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019.
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