VLKB091 Clinical Biochemistry

Faculty of Medicine
autumn 2024
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: k (colloquium).
Teacher(s)
MUDr. Lenka Gescheidtová, Ph.D. (lecturer)
MUDr. Michaela Jurčišinová (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
MUDr. Ondřej Kyselák, Ph.D., EuSpLM (lecturer)
MUDr. Jan Novák, Ph.D. (lecturer)
MUDr. Lukáš Opatřil, Ph.D. (lecturer)
prof. MUDr. Vladimír Soška, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
Mgr. Ondřej Wiewiorka, Ph.D. (lecturer)
MUDr. Ing. David Zeman, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: MUDr. Michaela Králíková, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
VLPF0622p Pathophysiology II - lecture || ZLPF0622p Pathophysiol. II - lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
To introduce students with - the factors affecting laboratory test results and their interpretation - principles of proper collection and processing of biological material - the evaluation of the validity of laboratory tests - laboratory diagnosis of selected diseases.
Learning outcomes
Student will be able to:
purposefully indicate laboratory biochemical tests
correctly interpret laboratory results
evaluate laboratory tests with regard to their sensitivity and specificity, and predictive value
use knowledge of the uncertainty of the evaluated parameter
to focus on possible pre-analytical influences and interferences
Syllabus
  • Biochemical tests - variability and reliability of the result, specificity, sensitivity, validity, reference limits, uncertainty, ROC curves. Preanalytical influences on laboratory examination.
  • Diagnosis and monitoring of nutritional status. Principles of parenteral and enteral nutrition. Energy sources.
  • Energy expenditure, nitrogen balance. Oxygen, transport and oxygenation disorders. Load states, energy balance.
  • Disorders of lipid metabolism.
  • Biochemical markers in cardiology.
  • Management of water and mineral substances. Serum and urine osmolality.
  • Acid-base metabolism. Examination indications, interpretation of parameters.
  • Importance of determination of Na, K, Cl.
  • Biochemical diagnosis of kidney diseases, their monitoring. Functional tests. Urinary sediment. Hemodialysis.
  • Biochemical examination of the liver and bile ducts. Manifestations of damage, differential diagnosis of jaundice, cholestatic syndrome.
  • Biochemical examination of the gastrointestinal tract. Gastric secretions, resorption disorders and intestinal diseases, pancreatic function tests.
  • Disorders of glucose metabolism, diabetes mellitus.
  • Metabolism of essential trace elements.
  • Biochemical examination of the pituitary gland, thyroid gland and adrenal glands.
  • Calcium and phosphate metabolism. Markers of bone metabolism. Vitamin D.
  • Tumor markers.
  • Blood serum proteins. Acute phase reactants. Monoclonal gammopathy.
  • Biochemical and morphological examination of cerebrospinal fluid.
  • Inherited disorders of metabolism; congenital metabolic defects; newborn screening.
  • Peculiarities of laboratory investigation in childhood.
Literature
    required literature
  • RACEK, Jaroslav and Daniel RAJDL. Klinická biochemie. Třetí, přepracované a ro. Praha: Galén, 2021, 454 stran. ISBN 9788074925450. info
  • Klinická biochemie (interaktivní osnova, ozvučené prezentace).
    recommended literature
  • Rajdl. D. a kol. Clinical biochemistry (e-book, formats: .pdf, .epub, .mobi) 1st ed. Prague, Karolinum Press, 2016, 426 s. ISBN: 978-80-246-3497-5. Download: https://karolinum.cz/en/books/rajdl-clinical-biochemistry-17096
  • JABOR, A. Vnitřní prostředí. 1st ed. Praha: Grada Publishing,a.s., 2008, 2009, 560 pp. ISBN 978-80-247-1221-5. info
  • KAZDA, Antonín. Kritické stavy : metabolická a laboratorní problematika. První vydání. Praha: Galén, 2012, 346 stran. ISBN 9788072627639. info
  • WALKER, Simon A. Lecture notes clinical biochemistry. 9th ed. Chichester, West Sussex: Wiley-Blackwell, 2013, xii, 290. ISBN 9781118272138. info
Teaching methods
Lectures, case reports.
Assessment methods
The colloquium – a written test.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Note related to how often the course is taught: 1.–11./12. výukový týden.
Information on the extent and intensity of the course: 30.
Information on course enrolment limitations: Kromě studentů LF maximálně 3 studenti MU.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Spring 2007, Autumn 2007, Spring 2008, Autumn 2008, Spring 2009, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2024/VLKB091