Special Biology (programme PřF, B-EXB, specialization Experimental Biology of Animals and Immunology)
Special Biology (programme PřF, B-EXB, specialization Mikrobiology a Molecular Biotechnology)
At the end of the course students should be able to:
understand basic principles of immunology;
explain principles of immune response, immunoregulation, and immunomodulation;
differentiate mechanisms of hypersensitivity;
define the role of cytokines and immunomodulators;
explain mechanisms of antiinfection immunity.
1. Introduction to immunobiology. 2.Cells and organs of the immunity - ontogenesis, phenotype, structure, function and activation, signal receptors: 3.Immune response: antigens, structure, chemical properties, classification, presentation, MHC structure, function, regulation, immunogenetics: gene displacement, polymorphism, genesis of diversity Antibodies: structure, chemical properties, functions, classes of antibodies, isotypes, allotypes, idiotypes T-cell receptors: structure, function and antigen binding, interaction of receptors with ligands: adhesive molecules, complement receptors, Fc receptors, transfer of signals Nonspecific immunity: complement: structure and function, acute phase reactants, inflammation Phagocytosis: phases, cooperation of the phagocytosis with other components of the immune system 4.The mechanism of the hypersensitivity: IgE mediated / early and late response; IgG, IgA and IgM mediated; immune complexes mediated; cell mediated. 5. Cytokines and immunomodulators: cytokines: properties, origin, structure, effect, receptor-place of effect, metabolism, regulation and gene activation. Inflammatory mediators: origin, structure, effect, receptor-place of effect, metabolism and regulation 6.Immunoregulation: toleration, clonal selection, inhibition, antigenic paralytic intracellular - interaction: help and inhibition (suppression). Idiotype network: inhibition and stimulation. Mechanisms of auto-immunity 7. Antiinfection immunity: immunity against viruses, bacteria, fungi, parasites. 8. Failures of host defence mechanisms, primary and secondary immunodeficiencies. 9. Immunity and cancer, transplantation immunology, immunotoxicology 10.Immunomodulation 11. Methods used in immunology.