Special Biology (programme PřF, B-EXB, specialization Experimental Biology of Animals and Immunology)
Special Biology (programme PřF, B-EXB, specialization Mikrobiology a Molecular Biotechnology)
At the end of the course students should be able to:
understand basic principles of immunology;
explain principles of immune response, immunoregulation, and immunomodulation;
differentiate mechanisms of hypersensitivity;
define the role of cytokines and immunomodulators;
explain mechanisms of antiinfection immunity.
1. Introduction to immunobiology. 2.Cells and organs of the immunity - ontogenesis, phenotype, structure, function and activation, signal receptors: 3.Immune response: antigens, structure, chemical properties, classification, presentation, MHC structure, function, regulation, immunogenetics: gene displacement, polymorphism, genesis of diversity Antibodies: structure, chemical properties, functions, classes of antibodies, isotypes, allotypes, idiotypes T-cell receptors: structure, function and antigen binding, interaction of receptors with ligands: adhesive molecules, complement receptors, Fc receptors, transfer of signals Nonspecific immunity: complement: structure and function, acute phase reactants, inflammation Phagocytosis: phases, cooperation of the phagocytosis with other components of the immune system 4.The mechanism of the hypersensitivity: IgE mediated / early and late response; IgG, IgA and IgM mediated; immune complexes mediated; cell mediated. 5. Cytokines and immunomodulators: cytokines: properties, origin, structure, effect, receptor-place of effect, metabolism, regulation and gene activation. Inflammatory mediators: origin, structure, effect, receptor-place of effect, metabolism and regulation 6.Immunoregulation: toleration, clonal selection, inhibition, antigenic paralytic intracellular - interaction: help and inhibition (suppression). Idiotype network: inhibition and stimulation. Mechanisms of auto-immunity 7. Antiinfection immunity: immunity against viruses, bacteria, fungi, parasites. 8. Failures of host defence mechanisms, primary and secondary immunodeficiencies. 9. Immunity and cancer, transplantation immunology, immunotoxicology 10.Immunomodulation 11. Methods used in immunology.
TOMAN, Miroslav. Veterinární imunologie. 1. vyd. Praha: Grada, 2000. 413 s. ISBN 8071697273. info
Immunobiology : the immune system in health and disease. Edited by Charles Janeway. 6th ed. New York, N.Y.: Garland Science, Taylor & Francis Group, 2005. xxiii, 823. ISBN 0815341016. info
KREJSEK, Jan and Otakar KOPECKÝ. Klinická imunologie. 1. vyd. Hradec Králové: NUCLEUS HK, 2004. 941 s. ISBN 808622550X. info
Lectures and presentations by specialists in the individual sectors of immunology.
Written examination which consists of 12 questions. It is necessary to obtain at least 16 points (maximum 30 points) for successful passing.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!