VLFA0722p Pharmacology - lectures

Faculty of Medicine
autumn 2019
Extent and Intensity
2/0/0. 5 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
MUDr. Lea Janáková, Ph.D. (lecturer)
Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Jana Merhautová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
doc. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
doc. RNDr. Lenka Zdražilová Dubská, Ph.D. (lecturer)
PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Renata Bláblová (assistant)
Ing. Lenka Hořavová (alternate examiner)
Mgr. Kateřina Nebeská (alternate examiner)
Mgr. Kristýna Nosková (alternate examiner)
PharmDr. Adriána Papiež, Ph.D. (alternate examiner)
PharmDr. Jitka Rychlíčková, Ph.D. (alternate examiner)
Supervisor
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
VLFA0621c Pharmacology I - p && ( VSAJ0222 English 1 II -p || VLAJ0222 English 1 II -p || VSCJ0686 Czech for Foreigners VI -p || VSNJ0222 German 1 II -p || VSSJ0222 Spanish 1 II -p )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
Fields of study the course is directly associated with
Course objectives
At the end of the course student will be oriented in drug classes according to their main therapeutic indications, in pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions. The student will be able to judge pharmacoeconomic analyses for pharmacotherapy used in practice.
Learning outcomes
At the end of the course student will be oriented in drug classes according to their main therapeutic indications, in pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions. The student will be able to judge pharmacoeconomic analyses for pharmacotherapy used in practice.
Syllabus
  • VLFA07212p - Pharmacology I - Lectures

    General medicine

    Autumn semester 2018

  • 1st week
  • Topic: PHARMACOLOGY AND ITS SUB-BRANCHES
  • Course content: Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
  • 2nd week
  • Topic: OVERVIEW OF DRUG DOSAGE FORMS
  • Course content: Classification and overview of drug dosage forms for ready-made production and individual preparation, advantages and disadvantages of the particular types of drug dosage forms in clinical use, typical auxiliary substances (excipients). Drug dosage forms with controlled release.
  • 3rd week
  • Topic: ROUTES OF DRUG ADMINISTRATION
  • Course content: Classification of routes of administration, description of the individual ways with examples of drugs. Overview of innovative administration routes.
  • 4th week
  • Topic: PHARMACOKINETICS I
  • Course content: General principles of drug fate in the organism. Overview of the individual pharmacokinetic processes and parameters.
  • 5th week
  • Topic: PHARMACOKINETICS II
  • Course content: Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
  • 6th week
  • Topic: PHARMACODYNAMICS
  • Course content: Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
  • 7th week
  • Topic: DRUG SAFETY
  • Course content: Adverse drug effects - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
  • 8th week
  • Topic: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenetics.
  • 9th week
  • Topic: PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
  • Course content: Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
  • 10th week
  • Topic: RESEARCH IN PHARMACOLOGY
  • Course content: Methods of experimental pharmacological research – brief overview. Examples from the Department of Pharmacology - Faculty of Medicine, MU.
  • 11th week
  • Topic: BASIC PRINCIPLES OF BIOLOGICAL THERAPY
  • Course content: Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use.
  • 12th week
  • Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
  • 13th week
  • Topic: PHARMACOLOGY OF SEX HORMONES
  • Course content: Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
  • 14th week
  • Topic: ANALGESIC DRUGS
  • Course content: Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
  • 15th week
  • Topic: GENERAL AND LOCAL ANAESTHETIC AGENTS
  • Course content: Classification and pharmacological characteristics of general and local anaesthetic drugs.
  • ----------------------------------------------------------------------------------------------------------------------------------------
  • VLFA0722p - Pharmacology II - Lectures

    General medicine

    Autumn semester 2017

  • 28.9.2017
  • Bank Holiday.
  • 5.10.2017
  • Antihypertensives. Diuretics, antiadrenergics, vasodilators, combinative pharmacotherapy.
  • 12.10.2017
  • Pharmacotherapy of heart failure. Inotropic drugs (digitalis, amrinone, dobutamine).
  • 19.10.2017
  • Introduction to psychopharmacology. Neurotransmitter mechanisms and specific neurotransmitter systems. Antipsychotics.
  • 26.10.2017
  • Anti-Parkinson pharmacotherapy. Drugs used in Alzheimer`s disease and other states of dementia. Anti-manic drugs.
  • 2.11.2017
  • Drug addiction.
  • 9.11.2017
  • Principles of biological therapy, monoclonal antibodies and therapeutic use.
  • 16.11.2017
  • Principles of targeted therapy in oncology, monoclonal antibodies, tyrosinkinases inhibitors. Adverse drug reactions.
  • 23.11.2017
  • Antimycotics, mechanism of action and adverse effects. Antivirotics.
  • 30.11.2017
  • Basic principles of immunotherapy. Advanced therapy medicinal products.
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
  • WHALEN, Karen. Lippincott illustrated reviews : Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    not specified
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993. 97 s. ISBN 80-210-0640-4. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
Teaching methods
According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.
Assessment methods
The final exam is guided by the entrance test (ROPOT, the test contains 30 questions randomly generated for individual student (number of correct answers indicated)). In case of successful completion of the entrance test the exam continues by oral examination (three randomly selected questions corresponding with Syllabus (general pharmacological principles, drug classes, question of detailed knowledge about a selected drug).
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018.
  • Enrolment Statistics (autumn 2019, recent)
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