VLFA08222p Farmakologie II - přednáška

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
MVDr. Eva Dražanová, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Alena Máchalová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Carlos Daniel Ferreira Fonseca, MSc. (seminar tutor)
MUDr. Tomáš Sokop (seminar tutor)
Mgr. Zuzana Strašilová (seminar tutor)
Renata Bláblová (assistant)
MUDr. Filip Šiška (assistant)
Mgr. Marta Vyoralová (assistant)
Mgr. Nina Zemanová, Ph.D. (assistant)
PharmDr. Adéla Bártová (alternate examiner)
PharmDr. Tomáš Hammer (alternate examiner)
PharmDr. Mária Hricková (alternate examiner)
Mgr. Petr John (alternate examiner)
Mgr. Nina Zemanová, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Barbora Říhová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. 17:00–18:40 Virtuální místnost, Mon 26. 2. 17:00–18:40 Virtuální místnost, Mon 4. 3. 17:00–18:40 Virtuální místnost, Mon 11. 3. 17:00–18:40 Virtuální místnost, Mon 18. 3. 17:00–18:40 Virtuální místnost, Mon 25. 3. 17:00–18:40 Virtuální místnost, Mon 8. 4. 17:00–18:40 Virtuální místnost, Mon 15. 4. 17:00–18:40 Virtuální místnost, Mon 22. 4. 17:00–18:40 Virtuální místnost, Mon 29. 4. 17:00–18:40 Virtuální místnost, Mon 6. 5. 17:00–18:40 Virtuální místnost, Mon 13. 5. 17:00–18:40 Virtuální místnost, Mon 20. 5. 17:00–18:40 Virtuální místnost, Mon 27. 5. 17:00–18:40 Virtuální místnost
Prerequisites (in Czech)
VLFA07212p Pharmacology I
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to acquiant the students with drug profiles of selected pharmacotherapeutic groups.
Learning outcomes
At the end of the course student should be able choose and prescribe suitable drug for the patient with known indicication. The selection will be made with respect to all factors influencing drug safety and efficacy.
Syllabus

  • VLFA08222p - Pharmacology II lecture

    Spring semester 2024

  • 1. INTRODUCTION TO PSYCHOPHARMACOLOGY, ANTIPSYCHOTICS, ANTIPARKINSONICS
  • Lecture content: Overview of neurotransmitters and their functions. History and classification of psychotropic substances. Antipsychotics, antiparkinsonics – basic pharmacological review.
  • 2. ANTIDEPRESSANTS
  • Lecture content: Pharmacological review of antidepressants and their clinical use.
  • 3. ANXIOLYTICS, HYPNOSEDATIVES, ANTICONVULSANTS
  • Lecture content: Anxiolytics, hypnosedatives, anticonvulsants - basic pharmacological review. The possibilities of modulation of GABAergic neurotransmission.
  • 4. GENERAL AND LOCAL ANAESTHETIC AGENTS
  • Lecture content: Classification and pharmacological characteristics of general and local anaesthetic drugs.
  • 5. VASODILATORS
  • Lecture content: Hypolipidemic drugs, antiobesity drugs, nitrates, Ca channel blockers - DHP. Risk factors of cardiovascular disorders. Pharmacotherapy of dyslipidaemia and ischaemic heart disease.
  • 6. DRUGS INFLUENCING RAAS, DIURETICS
  • Lecture content: ACE inhibitors, AT-II receptor antagonists, renin antagonists, diuretics, mineralocorticoid receptor antagonists. Antihypertensives.
  • 7. DRUGS INFLUENCING MYOCYTES
  • Lecture content: Beta-blockers and bradines, positive inotropics, Ca channel blockers - nonDHP, antiarrhythmic drugs. Drugs in heart failure.
  • 8. DRUGS INFLUENCING HAEMOSTASIS
  • Lecture content: Pharmacological review of anticoagulants, antiplatelets, fibrinolytics, and haemostatics
  • 9. ANTI-INFECTIVES I - ANTIBIOTICS
  • Lecture content: Introduction/principles of ATB therapy, mechanisms of bacterial resistance, pharmacological profiles of ATBs.
  • 10. ANTI-INFECTIVES II – ANTIMYCOTICS AND ANTIVIRALS
  • Lecture content: Systemic and local antimycotics; antiherpetics; pharmacotherapy of influenza; antiretrovirals; therapy of RSV and viral hepatitis – pharmacological review.
  • 11. PHARMACOLOGY OF GIT – ULCER DISEASE, ANTIEMETICS, ANTIDIARRHEALS AND LAXATIVES
  • Lecture content: Pharmacological review of drugs acting on GIT.
  • 12. CYTOSTATICS AND TARGETED DRUGS IN ONCOLOGY
  • Lecture content: Introduction. Classification of cytostatics according to their mechanisms of action. Mechanisms of resistance to anticancer drugs. Role of single nucleotide polymorphisms (SNPs) and TDM in oncology. Basic pharmacological properties of selected cytostatics. Principles of targeted therapy in oncology. Monoclonal antibodies. Protein kinase inhibitors. Targeted immunotherapy.
  • 13. THERAPY OF INTOXICATIONS
  • Lecture content: Review of most common intoxications and their symptomatology. General principles of poisoning management. Specific antidotes in poisoning therapy.
  • 14. DRUG-DRUG INTERACTIONS
  • Lecture content: Classification of drug-drug interaction, evaluation of clinical relevance and seriousness oc drug interactions, management of drug interactions, possibilities of drug interactions monitoring, case-reports.
  • 15. PHYTOPHARMACOLOGY AND PHARMACOGNOSY
  • Lecture content: Natural sources of medicines, selected groups of herbal active components, herbal preparations. The most common herbal poisons.
Literature
    required literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN and H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier. xvi, 789. ISBN 9780702074486. 2020. info
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MacEWAN, Emma ROBINSON, James FULLERTON. Rang and Dale's pharmacology. Tenth edition. Elsevier, 2023. 850 p. ISBN 9780323873956.
  • Studijní materiály z IS pod kódem předmětu
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů :: Portál Lékařské fakulty Masarykovy
    recommended literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone. xv, 760. ISBN 9780702053627. 2016. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • Farmakologie. Edited by Jan Švihovec - Jan Bultas - Pavel Anzenbacher - Jaroslav Chládek - J. 1. vydání. Praha: Grada Publishing. xix, 962. ISBN 9788024755588. 2018. info
    not specified
  • Osnovy zkouškových otázek
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • Markova farmakoterapie vnitřních nemocí. Edited by Josef Marek - Michal Vrablík. 5., zcela přepracované a d. Praha: Grada. xxiv, 868. ISBN 9788024750781. 2019. info
  • STEVENS, Craig W. Brenner and Stevens' pharmacology. Sixth edition. Philadelphia, PA: Elsevier. viii, 594. ISBN 9780323758987. 2023. info
  • WALLER, Derek, Anthony P. SAMPSON and Andrew W. HITCHINGS. Medical pharmacology and therapeutics. Sixth edition. London: Elsevier. vii, 742. ISBN 9780702081590. 2022. info
  • BROWN, M. J., Pankaj SHARMA, Fraz A. MIR and P. N. BENNETT. Clinical pharmacology. Twelfth edition. Edinburgh: Elsevier. 1 online. ISBN 9780702073304. 2019. URL info
Teaching methods
video recordings of lectures in IS
Assessment methods
The final evaluation of the course contains also results of the tests from practicals of both semesters and results of colloquium test.

The final mark is calculated by following method:

Relative weight of the mark from tests: 30 %
Relative weight of the mark from oral exam: 70 %

To calculate mark from the tests the following method will be used:
The summary score from all tests in courses VLFA07212c, VLFA07212p, VLFA08222c, and VLFA08222p is 230 pts. Minimum to pass through the course to the oral exam is 128 pts.
A = 210-230 pts
B = 190-209 pts
C = 160-189 pts
D = 140-159 pts
E = 128-139 pts
F = less than 128 pts

To calculate mark from the oral examthe following method will be used:
Three different questions are chosen by students from three different sets of questions at oral exam. Moreover the student answers additional questions of examinator. Drawn questions from General and Special pharmacology and the additional questions have relative weight of 30 %. The question on essential drugs has realtive weight 10 % in the final mark of the oral exam. When student is evaluated by F for any of these questions the overall rating of oral exam is also F.

In case of success with the ROPOT test (at least 40 pts.), but classification F from the oral part, students enter the oral part next time and for the final mark the score from the last ROPOT attempt is used.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms spring 2019, spring 2020, spring 2021, spring 2022, spring 2023.
  • Enrolment Statistics (recent)
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