BVPF0321p Pathophysiology I - lecture

Faculty of Medicine
Autumn 2008
Extent and Intensity
2/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
Věra Ježková (assistant)
MUDr. Michal Jurajda, Ph.D. (lecturer)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
Mgr. Monika Chmelíková, Ph.D. (seminar tutor)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Timetable
Mon 13:30–15:15 A16/215
Prerequisites (in Czech)
BKFY0222p Physiology II-lec. && VSBC0221p Biochemistry I -lect. && BVAT0111 Anatomy of Digestive System
Fyziologie, biochemie
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Main objectives are to provide student with basic understanding of following topics: Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - disease causes
Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing - cell cycle control - malignant transformation of the cell - metastases
Inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)
Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence
Principles of genetics – monogennic vs. complex diseases
Homeostasis – regulation and disorders of physiologic regulations – chronobiology
Pathophysiology of endocrine system
Disorders of volume, osmotic and acid-base balance
Intermediary metabolism – metabolic regulations – energy – disorders of carbohydrate, lipid and protein metabolism
Syllabus
  • 15/9: Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - internal and external disease causes(Doc. MUDr. Kateřina Kaňková, PhD.)
  • 22/9: Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 29/9: General signs of disease - inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)(Doc. MUDr. Kateřina Kaňková, PhD.)
  • 6/10: Cell cycle control - malignant transformation of the cell - metastases - tumor vs. host interaction (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 13/10: Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence (MUDr. Michal Jurajda, PhD.)
  • 20/10: Principles of genetics – monogennic vs. complex diseases (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 27/10: Homeostasis – regulation and disorders of physiologic regulations – chronobiology - pathophysiology of endocrine system I - hypothalamus, hypophysis (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 3/11: Pathophysiology of endocrine system II – adrenals, thyroid gland štítná žláza, parathyroid bodies, endocrinne pancreas (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 10/11: Disorders of volume and osmotic balance (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 24/11: Disorders of acid-base balance (MUDr. Michal Jurajda, PhD.)
  • 1/12: Intermediary metabolism – metabolic regulations – energy – assessment of nutritional status (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 8/12: Disorders of metabolism I - carbohydrates – diabetes mellitus – diabetic angiopathy and other complications (Doc. MUDr. Kateřina Kaňková, PhD.)
  • 15/12: Disorders of metabolism II – lipids – dyslipidemias (Doc. MUDr. Kateřina Kaňková, PhD.)
Literature
  • KAŇKOVÁ, Kateřina; Dobroslav HÁJEK; Marcel HORKÝ; Lydie IZAKOVIČOVÁ HOLLÁ; Michal JURAJDA; Vladimír KOTALA; Jiří VÁCHA; Anna VAŠKŮ and Vladimír ZNOJIL. Patologická fyziologie pro bakalářské studijní programy (Pathophysiology for paramedical study programms). 1st ed. Brno: Masarykova univerzita v Brně, 2003, 161 pp. 1. vydání. ISBN 80-210-3112-3. info
  • KAŇKOVÁ, Kateřina. Vybrané kapitoly z patologické fyziologie: Poruchy metabolizmu a výživy. 1. vydání. Brno: Masarykova univerzita v Brně, 2005, 59 pp. ISBN 80-210-3670-2. info
Assessment methods
lecture, credit
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
General note: Studenti opakující 2. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024, autumn 2025.
  • Enrolment Statistics (Autumn 2008, recent)
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