LF:BVPF0321p Pathophysiology I - lecture - Course Information
BVPF0321p Pathophysiology I - lecture
Faculty of Medicineautumn 2020
- Extent and Intensity
- 2/0/0. 2 credit(s). Type of Completion: z (credit).
- Teacher(s)
- prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
MUDr. Michal Jurajda, Ph.D. (lecturer)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
Věra Ježková (assistant)
Mgr. Katarína Chalásová, Ph.D. (lecturer) - Guaranteed by
- prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine - Timetable
- Mon 13:00–14:40 A21/111
- Prerequisites
- BKFY0222p Physiology II - lecture && BVBC0221p Biochemistry -lect. && BVAT011p Anatomy of Digestive System
Physiology, biochemistry - Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Nutritive therapist (programme LF, B-SZ)
- Dietitian (programme LF, B-NUT)
- Course objectives
- Main objectives are to provide student with basic understanding of following topics:
Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - disease causes
Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing - cell cycle control - malignant transformation of the cell - metastases
Inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)
Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence
Principles of genetics – monogennic vs. complex diseases
Homeostasis – regulation and disorders of physiologic regulations – chronobiology
Pathophysiology of endocrine system
Disorders of volume, osmotic and acid-base balance
Intermediary metabolism – metabolic regulations – energy – disorders of carbohydrate metabolism - Learning outcomes
- Student will be able, after completing the course (with account of the width of the subject):
- to characterize the state of health and illness in terms of different concepts
- to distinguish the genetic determinants of disease, the influence of external factors on the occurrence of diseases, the difference between monogenic and multigenic/complex disease
- to orientate in terms: cell, cell cycle
- to characterize the term homeostasis
- to discuss external and internal factors of the disease
- to characterize basic concepts of tissue involvement and wound healing
- to explain the difference between local and systemic inflammation
- to explain the chronobiology function in medicine
- to discuss the etiopathogenesis of the most important disorders of ion equilibrium and regulation of volume and tonicity
- to define basic concepts of acid-base balance
- to evaluate the importance of abnormalities of the most important micronutrients, disorders in vitamin levels and trace elements
- to define the disorders in metabolism of carbohydrates, lipids, proteins and amino acids
- to characterize energy balance disorders - Syllabus
- 1: Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - internal and external disease causes
- 2: Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing
- 3: General signs of disease - inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)
- 4: Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence
- 5: Cell cycle control - malignant transformation of the cell - metastases - tumor vs. host interaction
- 6: Principles of genetics – monogennic vs. complex diseases
- 7: Homeostasis – regulation and disorders of physiologic regulations – chronobiology - pathophysiology of endocrine system I - hypothalamus, hypophysis
- 8: Pathophysiology of endocrine system II – adrenals, thyroid gland štítná žláza, parathyroid bodies, endocrinne pancreas
- 9: Disorders of volume and osmotic balance
- 10: Disorders of acid-base balance
- 11: Disorders of metabolism I - carbohydrates – diabetes mellitus
- 12: Disorders of metabolism II - lipids
- 13: Disorders of metabolism III - purins, pyrimidins, porfyrins and hem
- 12: Disorders of metabolism IV - micronutrients, vitamins
- Literature
- recommended literature
- KAŇKOVÁ, Kateřina; Dobroslav HÁJEK; Marcel HORKÝ; Lydie IZAKOVIČOVÁ HOLLÁ; Michal JURAJDA; Vladimír KOTALA; Jiří VÁCHA; Anna VAŠKŮ and Vladimír ZNOJIL. Patologická fyziologie pro bakalářské studijní programy (Pathophysiology for paramedical study programms). 1st ed. Brno: Masarykova univerzita v Brně, 2003, 161 pp. 1. vydání. ISBN 80-210-3112-3. info
- KAŇKOVÁ, Kateřina. Vybrané kapitoly z patologické fyziologie: Poruchy metabolizmu a výživy. 1. vydání. Brno: Masarykova univerzita v Brně, 2005, 59 pp. ISBN 80-210-3670-2. info
- Teaching methods
- lecture
- Assessment methods
- Examination in the second semester of study. The credits are awarded for a minimum of 10 lectures. In case of non-fulfillment the student writes a written test consisting of 20 questions. Successful passing requires 60% of the right answers.
- Language of instruction
- Czech
- Follow-Up Courses
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.
General note: Studenti opakující 2. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období. - Listed among pre-requisites of other courses
- Enrolment Statistics (autumn 2020, recent)
- Permalink: https://is.muni.cz/course/med/autumn2020/BVPF0321p