ZLPF0521p Pathological Physiology I - lecture

Faculty of Medicine
autumn 2018
Extent and Intensity
2/0/0. 0 credit(s). Type of Completion: -.
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Lydie Izakovičová Hollá, Ph.D. (assistant)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Mon 17. 9. to Wed 3. 10. Thu 13:20–15:00 N03901, Thu 4. 10. to Thu 20. 12. Thu 15:20–17:00 N01008
Prerequisites (in Czech)
ZLFY0422p Physiology II - lecture && ZLBC041p Biochemistry II -lec. && ZLAN0333p Anatomy III - lect. && ZLHE0322p Hist.and Embryol.II-lect. && ( ZLLT0222s Bas.Med.Terminology II-sem. || ZLLT0222p Bas. Med. Terminology -l ) && ZLET021p Ethics in Dent.-lect. && ZC041 Handling chemical substances
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the theoretical part of the course is to provide complex information on etiology and pathogenesis of diseases. Basic knowledge of the origin and dynamics of the development of pathological states will be presented and trained during lectures and completed by individual study of recommended literature.
Learning outcomes
Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student demonstrates understanding of an influence of external factors on disease development, especially in oral cavity
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances, especially those of Ca++, Mg++ and K+
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing, especially in oral cavity
Student explains an importance of micronutrients abnormalities, especially considering oral cavity state
Student knows results of abnormal vitamin levels, especially in oral cavity
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes
  • Pathophysiology as a science: health and disease - common causes of diseases - etiology and pathogenesis – syndrome/symptom. External factors for onset of diseases – physical, chemical and biological pathogenic factors
  • Pathophysiology of cardiovascular system I – metabolism of myocardium - atherosclerosis – signs in some peripheral predilection localizations (limbs, brain)
  • Pathophysiology of cardiovascular system II – ischemic heart disease (angina pectoris and myocardium infarction) and selected disturbances of cardiac rhythm
  • Pathophysiology of cardiovascular system III – systemic arterial hypertension (SAH) and blood vessel remodeling
  • Pathophysiology of cardiovascular system IV – pressure and volume overload (including etiology of congenital heart defects, cardiomyopathies) - systolic and diastolic dysfunction –heart remodeling
  • Pathophysiology of respiratory system I – blood gases – disturbances in gas exchange in lungs (disturbance of ventilation, diffusion a perfusion) – ventilation-perfusion mismatch
  • Pathophysiology of respiratory system II – ventilation control – syndromes of respiratory insufficiency, lung edema, ARDs, selective restrictive lung diseases
  • Pathophysiology of respiratory system III – obstructive lung diseases (asthma bronchiale and CHOPN), pulmonary hypertension
  • Pathophysiology of kidneys and urinary tract I – regulation of glomerular hemodynamics – GFR and its examination – pathology of filtration membrane - proteinuria
  • Pathophysiology of kidneys and urinary tract II – glomerular diseases (glomerulopathies and glomerulonephrities)
  • Pathophysiology of kidneys and urinary tract III – acute and chronic renal failure
  • Disturbances of calcium and phosphates metabolism – pathophysiology of motoric system (bones and muscles)
    required literature
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003. s. 381-760. ISBN 9788024606743. info
  • NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000. 377 pp. ISBN 80-246-0051-X. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003. 379 s. ISBN 9788024606750. info
  • Ivan Damjanov: Pathophysiology, ISBN 13: 978-1-4160-0229-1, Saunders Elsevier, 2009.
    recommended literature
  • KAŇKOVÁ, Kateřina. Vybrané kapitoly z patologické fyziologie: Poruchy metabolizmu a výživy. 1. vydání. Brno: Masarykova univerzita v Brně, 2005. 59 pp. ISBN 80-210-3670-2. info
Teaching methods
Assessment methods
Oral examination.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Teacher's information
The course is also listed under the following terms Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2019, autumn 2020, autumn 2021.
  • Enrolment Statistics (autumn 2018, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2018/ZLPF0521p