ZLPA0521p Pathology I - lecture

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
prof. MUDr. Markéta Hermanová, Ph.D. (lecturer)
MUDr. Víta Žampachová (lecturer)
MUDr. Sylva Hotárková (lecturer)
MUDr. Iva Staniczková Zambo, Ph.D. (lecturer)
MUDr. Lukáš Velecký (lecturer)
MUDr. Michal Hendrych (seminar tutor)
Markéta Grozertová (assistant)
Mgr. Iva Holušová (assistant)
Guaranteed by
prof. MUDr. Markéta Hermanová, Ph.D.
First Department of Pathology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
Supplier department: First Department of Pathology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
Thu 13:30–15:10 N01008
Prerequisites (in Czech)
ZLFY0422p Physiology II - lecture && ( ZLBC041p Biochemistry II -lec. || ZLBC0422p Biochemistry II -lec. ) && ( ZLAN0333p Anatomy III - lect. || ZLAN0222p Anatomy III - lecture ) && ZLHE0322p Hist.and Embryol.II-lect. && ( ZLLT0222s Bas.Med.Terminology II-sem. || ZLLT011s Bas.Med.Terminology - sem. ) && ( ZLET021p Ethics in Dent.-lect. || ZLET011p Ethics in Dent.-lect. )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main aims of the course include:
understanding the basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
knowledge of basic classifications of non-neoplastic and neoplastic disorders
application of this knowledge in individual organ systems with focus on morphological substrate od individual disorders from both microscopis and macroscopic point of view
introduction of the role of pathology in clinical practice, of methods of tissue processing, methods of molecular pathology; demonstration of pathological anatomical autopsies and thier evaluation.
Learning outcomes
Completing the course, the student will be able:
to understand basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
to know basic classifications of both nonneoplastic and neoplastic disorders
to apply the knowledge of general pathology to individual organ systems: to know basic etiopathogenesis, both macroscopic and microscopic correlates, basic clinical symptoms and complications of diseases in individual organ systems
to know the role of pathology in clinical practive and main methods of examination in pathology.
  • Introduction: characteristics of pathology, pathology in practice. Methods in pathology (biopsy, cytology, molecular and genetic examination, autopsy.
  • Disease. Etiology of diseases: physical, chemical, nutritional, biological causes of disease. Genetic causes and enviromental factors.
  • Regressive changes: necrosis, apoptosis, atrophy, kachexy. Death. Progressive changes: regeneration, reparation, wounds and fractures healing, foreign body reaction, hypertrophy, hyperplasia, metaplasia.
  • Intracellular accumulation of glycids, lipids and proteins. Diabetes mellitus. Amyloidosis. Inclusions, Calcifications. Concrements and crystals. Pigments. Pneumoconioses.
  • Inflammation (definition, causes, macroscopic and microscopic features, mediators of inflammation, classification of inflammation).
  • Chronic inflammation. Granulomatous inflammation, Tbc.
  • Infectious causes of diseases. Bacteriemia, sepsis, pyemia, septic shock. HIV infection.
  • Disorders of immunity. Autoimmune disorders.
  • Hemodynamic disorders - local and systemic circulation disorders (hyperaemia, haemorrhage, haemorrhagic diatesis, thrombosis, ischaemia and infarction, embolism, oedema, dehydratation; causes and symptoms of circulation failure, shock).
  • General oncology.
  • Histogenetic classification of tumors. Pediatric tumors.
  • Hematooncology. Pathology of lymph nodes and haematopoetic tissues.
  • Cardiovascular pathology I: diseases of the heart, hypertension, acute and chronic heart failure.
    required literature
  • MAČÁK, Jirka, Jana MAČÁKOVÁ and Jana DVOŘÁČKOVÁ. Patologie. 2., doplněné vydání. Praha: Grada, 2012. 347 stran. ISBN 9788024735306. info
    recommended literature
  • KUMAR, Vinay, Abul K. ABBAS, Jon C. ASTER and Andrea T. DEYRUP. Robbins essential pathology. Philadelphia: Elsevier, 2021. viii, 340. ISBN 9780323640251. info
  • Patologie. Edited by Josef Zámečník. První vydání. Praha: LD Prager Publishing, 2019. xxvii, 282. ISBN 9788027064571. info
    not specified
  • POVÝŠIL, Ctibor and Ivo ŠTEINER. Obecná patologie. 1. vyd. Praha: Galén, 2011. xiii, 290. ISBN 9788072627738. info
  • Speciální patologie. Edited by Ctibor Povýšil - Ivo Šteiner. Druhé, doplněné a přepra. Praha: Galén, 2007. xviii, 430. ISBN 8024614427. info
Teaching methods
Pathology course consists of lectures and practical classes. Practical classes include two parts: histopathological practices (with demonstration of microscopic and macroscopic findings of bioptic and auroptic samples) and autoptical practices (with demonstration of pathological anatomical autopsies).
Assessment methods
The course of pathology is closed by oral exam covering three sets of topics: general pathology, systemic pathology and oncology. The list of these topics is available to the students in advance. Attendance is compulsory, knowledge of the students is periodically tested during the practical classes. Testing is oral or by written tests.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2022.
  • Enrolment Statistics (autumn 2021, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2021/ZLPA0521p