C2480 Fundamentals of Organic Chemistry and Biochemistry

Faculty of Science
Spring 2021
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
doc. RNDr. Ctibor Mazal, CSc. (lecturer)
Guaranteed by
doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry - Chemistry Section - Faculty of Science
Supplier department: Department of Chemistry - Chemistry Section - Faculty of Science
Mon 1. 3. to Fri 14. 5. Wed 16:00–17:50 online_CH4
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 13 fields of study the course is directly associated with, display
Course objectives
Main objectives can be summarized as follows:
to get a survey of basic concepts of general chemistry including basic chemical principles, molecular structure, and chemical bond theory;
to understand fundamentals of reaction kinetics, acid-base and redox equilibria;
to point out main groups of organic compounds and understand their structures and reactivity relationship;
to explain the basic principles of biochemistry on chemistry of main groups of biologically important compounds and fundamental biochemical processes.
Learning outcomes
After accomplishing the course, student will: - understand basic nomenclature of organic compounds;
- understand basic principles of general organic chemistry;
- be able to explain basic organic compounds structure-reactivity relationship.
- understand reaction of main classes of organic compounds;
- be able to work with the concept of chirality and optical activity;
- have a brief information about main classes of biochemically important compounds;
- be able to explain catabolic processes of sugars and lipids.
  • 1. Fundamentals of General Chemistry. Quantitative relationships in Chemical reactions. Atomic theory and chemical bond. Reaction kinetics and chemical equilibria. Acid/base equilibria, pH, pKa and pKb. Buffers.
  • 2. Saturated hydrocarbons. Nomenclature of alkanes and cycloalkanes. Structure and physical properties. Conformation. Chemical reactivity, radical substitution. Structure and stability of cycloalkanes. Geometric isomers.
  • 3. Unsaturated hydrocarbons. Naming of alkenes and alkynes. Structure and chemical reactivity, electrophilic addition. Markovnikov rule and stability of carbocations. Dienes. Benzene ring and aromaticity. Chemical reactivity of aromatic compounds, SEAr.
  • 4. Halogen derivatives. Naming, structure and physical properties. Chemical reactivity, nucleophilic substitution vs. elimination.
  • 5. Alcohols, phenols, ethers and their sulfur containing analogues. Naming, structure, physical properties, and chemical reactivity. Oxidation. Cyclic ethers.
  • 6. Aldehydes and ketones. Structure and physical properties. Naming. Chemical reactivity, oxidation, reduction, reaction with nucleophiles. Acetals. Aldol condensation.
  • 7. Carboxylic acids and their derivatives. Occurrence, naming, structure and physical properties. Chemical reactivity. Acidity, esterification and hydrolysis, Claisen condensation. Organophosphate esters and anhydrides.
  • 8. Nitrogen containing compounds. Nitroderivatives. Amines and amides. Structure and naming. Chemical reactivity, reduction of nitroderivatives, basicity of amines and quaternary ammonium salts.
  • 9. Stereoisomers. Molecular chirality and optical activity.
  • 10. Saccharides. Structure and chemical properties of saccharides. D- and L-families of carbohydrates. Fisher formulae. Cyclic forms of saccharides, epimerization. Glycoside bond, disaccharides and polysaccharides.
  • 11. Lipids. Classification of lipids. Fats - properties and hydrolysis. Fatty acids and soaps. Phospholipids. Steroids. Role of lipids in formation of cell membranes.
  • 12. Proteins. Aminoacids - buildings blocks of peptides. Peptide bond. Isoelectric point. Structure of proteins. Common properties of proteins. Classification and biological functions of proteins.
  • 13. Enzymes, hormones, and neurotransmitters. Fundamentals of simple enzyme kinetics. Enzyme regulation. Chemical communication - an overview.
  • 14. Nucleic acids. Structure of nucleic acids. DNA, RNA. Proteosynthesis. Viruses.
  • 15. Biological energetic. The citric acid cycle. The respiratory chain. Metabolism of carbohydrates and fats.
  • Fundamentals of general, organic, and biological chemistry. Edited by John R. Holum. 5th ed. New York: John Wiley & Sons, 1994. xvii, S. 2. ISBN 0-471-57949-1. info
  • POTÁČEK, Milan. Organická chemie pro biology. 1. vyd. Brno: Univerzita Jana Evangelisty Purkyně, 1988. 209 s. info
  • Vodrážka, Zdeněk . Biochemie. Praha: Academia, 1996, ISBN 80-200-0600-1
  • VACÍK, Jiří. Obecná chemie [Vacík, 1986]. 1. vyd. Praha: Státní pedagogické nakladatelství, 1986. 303 s. info
  • DUCHOŇ, Jiří. Lekárska chémia a biochémia. 1988. 749 s. info
Teaching methods
Assessment methods
Oral exam.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: nezapisují studenti dvouoborového studia biologie/chemie.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020.
  • Enrolment Statistics (recent)
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