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Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex J - Článek v odborném periodikuKLÁPŠŤOVÁ, Veronika; Kateřina ŠEDOVÁ; Josef HOUSER a Marek ŠEBESTA. Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex. JOURNAL OF BIOLOGICAL CHEMISTRY. AMSTERDAM: ELSEVIER, 2026, roč. 302, č. 1, s. 1-22. ISSN 0021-9258. Dostupné z: https://doi.org/10.1016/j.jbc.2025.111010.Podrobněji: https://is.muni.cz/publication/2556398/cs
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CDK7–CDK11 axis in spliceosome regulation and pre-mRNA splicing J - Článek v odborném periodikuRÁJECKÝ, Michal; Pavla GAJDUŠKOVÁ; Peter MANÍK; Milan HLUCHÝ; Eva HEGEDÜSOVÁ; Karolína KRYŠTOFOVÁ; David POTĚŠIL; Petra MARTINKOVÁ; Zuzana SLABÁ; Prashant KHIRSARIYA; Marek ŠEBESTA; Kamil PARUCH; Caroline C. FRIEDEL; Zbyněk ZDRÁHAL a Dalibor BLAŽEK. CDK7–CDK11 axis in spliceosome regulation and pre-mRNA splicing. Nucleic Acids Research. Oxford: Oxford University Press, 2025, roč. 53, č. 22, s. 1-23. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkaf1343.Podrobněji: https://is.muni.cz/publication/2552239/cs
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Mechanism of RNA polymerase II elongation complex condensation a - Konferenční abstraktŠEBESTA, Marek; Karel ŠKUBNÍK; William Shakespeare MORTON; Kateřina LINHARTOVÁ; Veronika KLÁPŠŤOVÁ; Jiří NOVÁČEK; Karel KUBÍČEK; Robert VÁCHA a Richard ŠTEFL. Mechanism of RNA polymerase II elongation complex condensation. In EMBO Workshop: In situ structural biology: expanding the toolbox for structural cell biology, Heidelberg. 2025.Podrobněji: https://is.muni.cz/publication/2552880/cs
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Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors J - Článek v odborném periodikuCARREIRA, Raquel; Tomas LAMA-DIAZ; Maria CRUGEIRAS; F Javier AGUADO; Marek ŠEBESTA; Lumír KREJČÍ a Miguel G BLANCO. Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors. Nucleic Acids Research. OXFORD: OXFORD UNIV PRESS, 2024, roč. 52, č. 12, s. 7012-7030. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkae453.Podrobněji: https://is.muni.cz/publication/2407841/cs
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Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5 helicase k - Prezentace na konferencíchŠEBESTA, Marek; Karel ŠKUBNÍK; William Shakespeare MORTON; Marek KRAVEC; Kateřina LINHARTOVÁ; Veronika KLÁPŠŤOVÁ; Jiří NOVÁČEK; Karel KUBÍČEK; Vítězslav BRYJA; Robert VÁCHA a Richard ŠTEFL. Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5 helicase. In 29th Annual International Conference RNA 2024, Edinburg. 2024.Podrobněji: https://is.muni.cz/publication/2476142/cs
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Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7 k - Prezentace na konferencíchLINHARTOVÁ, Kateřina; Francesco Luca FALGINELLA; Martin MÁTL; Marek ŠEBESTA; Robert VÁCHA a Richard ŠTEFL. Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7. In 16th EMBL Conference Transcription and chromatin, Heidelberg, 2024. 2024.Podrobněji: https://is.muni.cz/publication/2476128/cs
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Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7 J - Článek v odborném periodikuLINHARTOVÁ, Kateřina; Francesco Luca FALGINELLA; Martin MÁTL; Marek ŠEBESTA; Robert VÁCHA a Richard ŠTEFL. Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7. Nature Communications. Berlin: Nature Research, 2024, roč. 15, č. 1, s. 1-17. ISSN 2041-1723. Dostupné z: https://doi.org/10.1038/s41467-024-53305-2.Podrobněji: https://is.muni.cz/publication/2453137/cs
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Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway J - Článek v odborném periodikuGYBEĽ, Tomáš; Štěpán ČADA; Darja KLEMENTOVÁ; Martin P. SCHWALM; Benedict-Tilman BERGER; Marek ŠEBESTA; Stefan KNAPP a Vítězslav BRYJA. Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway. Journal of Biological Chemistry. Elsevier, 2024, roč. 300, č. 7, s. 1-22. ISSN 1083-351X. Dostupné z: https://doi.org/10.1016/j.jbc.2024.107407.Podrobněji: https://is.muni.cz/publication/2465622/cs
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Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II J - Článek v odborném periodikuKEOWN, Jeremy; Alaa BAAZAOUI; Marek ŠEBESTA; Richard ŠTEFL; Loic CARRIQUE; Ervin FODOR a Jonathan M GRIMES. Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II. Journal of Virology. WASHINGTON: American Society for Microbiology, 2024, roč. 98, č. 5, s. 1-15. ISSN 0022-538X. Dostupné z: https://doi.org/10.1128/jvi.00138-24.Podrobněji: https://is.muni.cz/publication/2419757/cs
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Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks J - Článek v odborném periodikuLONG, Qilin; Kamal AJIT; Kateřina ŠEDOVÁ; Vojtěch HALUZA; Richard ŠTEFL; Sadat DOKANEHEIFARD; Felipe BECKEDORFF; Monica G. VALENCIA; Marek ŠEBESTA; Ramin SHIEKHATTAR a Monika GULLEROVA. Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks. Nucleic acids research. Oxford: Oxford University Press, 2024, roč. 52, č. 21, s. 13036-13056. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkae937.Podrobněji: https://is.muni.cz/publication/2465588/cs
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The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid‐liquid phase separation at double‐strand breaks k - Prezentace na konferencíchLONG, Qilin; Kateřina ŠEDOVÁ; Vojtěch HALUZA; Adele ALAGIA; Zhichao LIU; Richard ŠTEFL; Monika GULLEROVA a Marek ŠEBESTA. The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid‐liquid phase separation at double‐strand breaks. In 29th Annual International Conference RNA 2024, Edinburg, 2024. 2024.Podrobněji: https://is.muni.cz/publication/2476145/cs
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Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor J - Článek v odborném periodikuHAŠANOVÁ, Zdenka; Veronika KLÁPŠŤOVÁ; Odil PORRUA; Richard ŠTEFL a Marek ŠEBESTA. Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor. Nucleic Acids Research. Oxford University Press, 2023, roč. 51, č. 6, s. 2818-2837. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkad092.Podrobněji: https://is.muni.cz/publication/2355898/cs
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The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks J - Článek v odborném periodikuLONG, Qilin; Marek ŠEBESTA; Kateřina ŠEDOVÁ; Vojtěch HALUZA; Adele ALAGIA; Zhichao LIU; Richard ŠTEFL a Monika GULLEROVA. The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks. Cell Reports. Elsevier, 2023, roč. 42, č. 12, s. 1-25. ISSN 2211-1247. Dostupné z: https://doi.org/10.1016/j.celrep.2023.113489.Podrobněji: https://is.muni.cz/publication/2364700/cs
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Cryo-EM reveals the structural basis for the regulatory function of HEL1 domain in vertebrate DICERs k - Prezentace na konferencíchZAPLETAL, David; Karel KUBÍČEK; Martina ZÁNOVÁ; Radek MALIK; Marek ŠEBESTA; Jiří NOVÁČEK; Petr SVOBODA a Richard ŠTEFL. Cryo-EM reveals the structural basis for the regulatory function of HEL1 domain in vertebrate DICERs. In Instruct Biennial Structural Biology ConferenceMuntgebouw, Utrecht, The Netherlands | 19-20 May, 2022. 2022.Podrobněji: https://is.muni.cz/publication/1862096/cs
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Structural and functional basis of mammalian microRNA biogenesis by Dicer J - Článek v odborném periodikuZAPLETAL, David; Eliska TABORSKA; Josef PASULKA; Radek MALIK; Karel KUBÍČEK; Martina ZÁNOVÁ; Christian MUCH; Marek ŠEBESTA; Valeria BUCCHERI; Filip HORVAT; Irena JENICKOVA; Michaela PROCHAZKOVA; Jan PROCHAZKA; Matyáš PINKAS; Jiří NOVÁČEK; Diego F JOSEPH; Radislav SEDLACEK; Carrie BERNECKY; Donal CARROLL; Richard ŠTEFL a Petr SVOBODA. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. CAMBRIDGE: CELL PRESS, 2022, roč. 82, č. 21, s. 4064-4079, 30 s. ISSN 1097-2765. Dostupné z: https://doi.org/10.1016/j.molcel.2022.10.010.Podrobněji: https://is.muni.cz/publication/2252813/cs
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PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC J - Článek v odborném periodikuAPPEL, Lisa-Marie; Vedran FRANKE; Melania BRUNO; Irina GRISHKOVSKAYA; Aiste KASILIAUSKAITE; Tanja KAUFMANN; Ursula E. SCHOEBERL; Martin G. PUCHINGER; Sebastian KOSTRHON; Carmen EBENWALDNER; Marek ŠEBESTA; Etienne BELTZUNG; Karl MECHTLER; Gen LIN; Anna VLASOVA; Martin LEEB; Rushad PAVRI; Alexander STARK; Altuna AKALIN; Richard ŠTEFL; Carrie BERNECKY; Kristina DJINOVIC-CARUGO a Dea SLADE. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. Nature Communications. London: Nature Publishing Group, 2021, roč. 12, č. 1, s. 6078-6101. ISSN 2041-1723. Dostupné z: https://doi.org/10.1038/s41467-021-26360-2.Podrobněji: https://is.muni.cz/publication/1838578/cs
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Structural Characterization of the Interaction Between BRCA1-BARD1 and RNA Polymerase II a - Konferenční abstraktKLÁPŠŤOVÁ, Veronika; Marek ŠEBESTA; Jiří NOVÁČEK a Richard ŠTEFL. Structural Characterization of the Interaction Between BRCA1-BARD1 and RNA Polymerase II. In CEITEC PhD Conference. 2020.Podrobněji: https://is.muni.cz/publication/1753036/cs
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A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance J - Článek v odborném periodikuSHEMESH, Keren; Marek ŠEBESTA; Martin PAČESA; Soumitra SAU; Alex BRONSTEIN; Oren PARNAS; Batia LIEFSHITZ; Česlovas VENCLOVAS; Lumír KREJČÍ a Martin KUPIEC. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Research. Oxford: Oxford University Press, 2017, roč. 45, č. 6, s. 3189-3203. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkw1348.Podrobněji: https://is.muni.cz/publication/1379549/cs
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Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains J - Článek v odborném periodikuŠEBESTA, Marek; Madhusoodanan URULANGODI; Barbora ŠTEFANOVIE; Barnabas SZAKAL; Martin PAČESA; Michael LISBY; Dana BRANZEI a Lumír KREJČÍ. Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains. Nucleic Acids Research. Oxford: Oxford University Press, 2017, roč. 45, č. 1, s. 215-230. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkw882.Podrobněji: https://is.muni.cz/publication/1357244/cs
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Role of PCNA and RFC in promoting Mus81-complex activity J - Článek v odborném periodikuSISÁKOVÁ, Alexandra; Veronika ALTMANNOVÁ; Marek ŠEBESTA a Lumír KREJČÍ. Role of PCNA and RFC in promoting Mus81-complex activity. BMC BIOLOGY. LONDON: BIOMED CENTRAL LTD, 2017, roč. 15, č. 90, s. 1-17. ISSN 1741-7007. Dostupné z: https://doi.org/10.1186/s12915-017-0429-8.Podrobněji: https://is.muni.cz/publication/1397142/cs
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The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis J - Článek v odborném periodikuBURKOVICS, Peter; Lili DOME; Szilvia JUHASZ; Veronika ALTMANNOVÁ; Marek ŠEBESTA; Martin PAČESA; Kasper FUGGER; Claus Storgaard SORENSEN; Marietta Y.W.T. LEE; Lajos HARACSKA a Lumír KREJČÍ. The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis. Nucleic Acids Research. Oxford: Oxford University Press, 2016, roč. 44, č. 7, s. 3176-3189. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkw024.Podrobněji: https://is.muni.cz/publication/1355901/cs
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Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication J - Článek v odborném periodikuURULANGODI, Madhusoodanan; Marek ŠEBESTA; Demis MENOLFI; Barnabas SZAKAL; Julie SOLLIER; Alexandra SISÁKOVÁ; Lumír KREJČÍ a Dana BRANZEI. Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication. Genes and Development. New York: Cold Spring Harbor Laboratory Press, 2015, roč. 29, č. 19, s. 2067-2080. ISSN 0890-9369. Dostupné z: https://doi.org/10.1101/gad.265629.115.Podrobněji: https://is.muni.cz/publication/1317033/cs
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Phosphorylation of Elg1 regulates its activity J - Článek v odborném periodikuŠEBESTA, Marek a Lumír KREJČÍ. Phosphorylation of Elg1 regulates its activity. Cell Cycle. Philadelphia: Taylor & Francis, 2015, roč. 14, č. 19, s. 3009-3010. ISSN 1538-4101. Dostupné z: https://doi.org/10.1080/15384101.2015.1084199.Podrobněji: https://is.muni.cz/publication/1317045/cs
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Strand invasion by HLTF as a mechanism for template switch in fork rescue J - Článek v odborném periodikuBURKOVICS, Peter; Marek ŠEBESTA; David BALOGH; Lajos HARACSKA a Lumír KREJČÍ. Strand invasion by HLTF as a mechanism for template switch in fork rescue. Nucleic Acids Research. Oxford: Oxford University Press, 2014, roč. 42, č. 3, s. 1711-1720. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkt1040.Podrobněji: https://is.muni.cz/publication/1160748/cs
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Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans J - Článek v odborném periodikuŠEBESTA, Marek; Peter BURKOVICS; Szilvia JUHASZ; Sufang ZHANG; Judit SZABO; Marietta Y. W. T. LEE; Lajos HARACSKA a Lumír KREJČÍ. Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair. AMSTERDAM: ELSEVIER SCIENCE BV, 2013, roč. 12, č. 9, s. 691-698. ISSN 1568-7864. Dostupné z: https://doi.org/10.1016/j.dnarep.2013.05.001.Podrobněji: https://is.muni.cz/publication/1124595/cs
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Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis J - Článek v odborném periodikuBURKOVICS, Peter; Marek ŠEBESTA; Alexandra SISÁKOVÁ; Nicolas PLAULT; Valeria SZUKACSOV; Thomas ROBERT; Lajos PINTER; María Victoria MARINI PALOMEQUE; Peter KOLESÁR; Lajos HARACSKA; Serge GANGLOFF a Lumír KREJČÍ. Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis. EMBO JOURNAL. NEW YORK: NATURE PUBLISHING GROUP, 2013, roč. 32, č. 5, s. 742-755. ISSN 0261-4189. Dostupné z: https://doi.org/10.1038/emboj.2013.9.Podrobněji: https://is.muni.cz/publication/1124592/cs
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The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination J - Článek v odborném periodikuBURGESS, Rebecca C.; Marek ŠEBESTA; Alexandra SISÁKOVÁ; María Victoria MARINI PALOMEQUE; Michael LISBY; Jiří DAMBORSKÝ; Hannah KLEIN; Rodney ROTHSTEIN a Lumír KREJČÍ. The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination. Plos One. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2013, roč. 8, č. 12, s. "e82630", 10 s. ISSN 1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0082630.Podrobněji: https://is.muni.cz/publication/1168310/cs
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Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities J - Článek v odborném periodikuŠEBESTA, Marek; Peter BURKOVICS; Lajos HARACSKA a Lumír KREJČÍ. Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities. DNA Repair. 2011, roč. 10, č. 6, s. 567-576. ISSN 1568-7864. Dostupné z: https://doi.org/10.1016/j.dnarep.2011.03.003.Podrobněji: https://is.muni.cz/publication/945695/cs