ZLPF0521c Pathological Physiology I - practice

Faculty of Medicine
autumn 2020
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Taught partially online.
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
doc. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
doc. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor), prof. MUDr. Julie Dobrovolná, Ph.D. (deputy)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Timetable of Seminar Groups
ZLPF0521c/21: Mon 30. 11. 7:00–12:20 A18/208, Tue 1. 12. 7:00–12:20 A18/208, Wed 2. 12. 7:00–12:20 A18/208, Thu 3. 12. 7:00–12:20 A18/208, Fri 4. 12. 7:00–12:20 A18/208
ZLPF0521c/22: Mon 19. 10. 7:00–12:20 A18/208, Tue 20. 10. 7:00–12:20 A18/208, Wed 21. 10. 7:00–12:20 A18/208, Thu 22. 10. 7:00–12:20 A18/208, Fri 23. 10. 7:00–12:20 A18/208
ZLPF0521c/23: Mon 16. 11. 7:00–12:20 A18/208, Wed 18. 11. 7:00–12:20 A18/208, Thu 19. 11. 7:00–12:20 A18/208, Fri 20. 11. 7:00–12:20 A18/208
ZLFY0422p Physiology II - lecture && ( ZLBC041p Biochemistry II -lec. || ZLBC0422p Biochemistry II -lec. ) && ( ZLAN0333p Anatomy III - lect. || ZLAN0222p Anatomy III - lecture ) && ZLHE0322p Hist.and Embryol.II-lect. && ( ZLLT0222s Bas.Med.Terminology II-sem. || ZLLT011s Bas.Med.Terminology - sem. ) && ( ZLET021p Ethics in Dent.-lect. || ZLET011p Ethics in Dent.-lect. )
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work, show anaesthetic and basic surgical techniques. Students will also acquire practical skills necessary for their subsequent(future) study and work.
Learning outcomes
Student applies the basic knowledge of biostatistics to explain the structure of reference intervals
: Student will describe the influence of ionizing radiation on the body at the level of molecular, cellular, tissue, and they justify the time dynamics of the system
: Student will describe changes in blood cell counts dynamics in the acute radiation disease
: Student makes a distinction between deterministic and stochastic effects of ionizing radiation and their practical implications
: Student will explain the principle of ultrasound and dopplerometric examination of the blood vessels, the underlying pathology of peripheral vasculature (venous valvular insufficiency, ischemia, short circuits, and steal syndromes)
: Student interprets the continuous ECG monitoring in experimental animals for several pathological conditions
: Student distinguishes ECG records most commonly occurring arrhythmias (sinus arrhythmia, SVES, atrial fibrillation, atrial flutter, AVRT, AV blockade blockade, ventricular tachycardia, torsades de pointes, ventricular fibrillation)
: Student demonstrates the basic static and dynamic parameters surveyed during the spirometric examination and their relationship to pulmonary diseased
: Student will describe the development of renal ischemia in experimental animal model
: Student will explain the determination of the glomerular filtration rate, depending on the curve of concentration of inulin excretion by the kidneys, while discussing the use of clearance of other substances (creatinine, PAH)
: Student demonstrates the emergence of renovascular hypertension in the Goldblatt´s model, renal artery stenosis, the difference between unilateral and bilateral stenosis, the role of the RAAS and the expansion of the volume due to hypertension diagnosis
  • Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry.
  • Cell cycle, oncogenes and supressor genes, cancer development.
  • Essential hypertension (seminar), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise.
  • Secondary hypertension (seminar), exp. induced renal ischemia (quantification of renal renin expression).
  • Atherosclerosis (seminar), principles and demonstration of peripheral blood flow examination using ultrasonography.
  • Renal disorders, acute renal insufficiency – measurement of GFR based on kinetics of renal inulin excretion.
  • Statistical analysis of experiments (introduction).
  • Acute radiation syndrome – haematological consequences.
  • Arrhytmias (seminar), demonstration of selected types of arrhythmias.
  • Acid-base balance disturbances, Credits.
Teaching methods
practical training
Assessment methods
Credit. Practical exercises are compulsory (one absence cen be tellerated, another ones can be excused only in case of sick leave). During the term, tutors can continuously test knowledge in written tests or students can be asked to elaborate special papers.Term tuition (blocks) is completed by credit, conditions for awarding credit are: i) participation in the practical exercises, ii) elaboration of protocols from experimental practical exercises, iii) further individually chosen tutor's criteria.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2021.
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