LF:VLFA07212p Farmakologie I - přednáška

VLFA07212p Farmakologie I - přednáška

Faculty of Medicine
Autumn 2017

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: k (colloquium).

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Prerequisites (in Czech)

VLPF0622p Pathophysiol. II - lect. && VLPA0622c Pathology - practice

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (programme LF, M-VL)

Course objectives

The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to explain the basic principles of therapy of intoxications
to describe the factors that influence the drug effect

Learning outcomes

Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
is able to suggest therapeutic measures in case of drug intoxication

Syllabus

Basic pharmacological terms, definitions. Physiological and pathological factors influencing drug effects. Adverse drug effects.
Drug delivery approaches, routes of administration, prolonged release preparations. The management of poisoning.
Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration. Basic principles of Pharmacogenetics.
Mechanisms of drug action, non-specific, specific. Receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors
Pharmacogenetics, pharmacogenomics amd their clinical implications.
Drug interactions. Assessment of the seriousness of drug interactions.
Pre-clinical and clinical drug development. Drug registration guidance. Regulation and guidelines for "Good Clinical Practice".
Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.
Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiarities. Specificities of pharmacotherapy in the elderly.

Literature

required literature

RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html

recommended literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info

not specified

http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
http://elportal.cz/publikace/kazuistiky-farmakologie
Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html

Teaching methods

lectures, presentations by professionals in the sectors

Assessment methods

Colloquium - ROPOT test

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

The course is also listed under the following terms autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.

Enrolment Statistics (Autumn 2017, recent)
Permalink: https://is.muni.cz/course/med/autumn2017/VLFA07212p

LF:VLFA07212p Farmakologie I - přednáška - Course Information

VLFA07212p Farmakologie I - přednáška

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