aVLFA0822c Farmakologie II - cvičení

Lékařská fakulta
jaro 2021
Rozsah
0/3/0. 45. 3 kr. Ukončení: z.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (náhr. zkoušející)
doc. PharmDr. Jan Juřica, Ph.D. (cvičící)
PharmDr. Katarína Kostolanská (cvičící)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (cvičící)
MUDr. Jana Pistovčáková, Ph.D. (cvičící)
PharmDr. Jitka Rychlíčková, Ph.D. (cvičící)
doc. PharmDr. Ondřej Zendulka, Ph.D. (cvičící)
Mgr. Petra Amchová, Ph.D. (pomocník)
doc. RNDr. Ladislava Bartošová, Ph.D. (pomocník)
Renata Bláblová (pomocník)
Mgr. Jana Kubátová, Ph.D. (pomocník)
Mgr. Kristýna Nosková, Ph.D. (pomocník)
MUDr. Jana Nováková, Ph.D. (pomocník)
doc. PharmDr. Jana Rudá, Ph.D. (pomocník)
Mgr. Barbora Říhová, Ph.D. (pomocník)
Květoslava Sedlářová (pomocník)
PharmDr. Lenka Součková, Ph.D. (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: doc. PharmDr. Ondřej Zendulka, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Předpoklady
aVLFA0721p Farmakologie I - přednáška && aVLPF0622p Pathophysiology II - lecture
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to acquiant the students with drugs from selected pharmacotherapeutic groups and to learn them how to use the drugs rationally with respect to their mode of action, indications and contraindications.
Výstupy z učení
At the end of the course student should be able choose and prescribe suitable drug for the patient with known indicication. The selection will be made with respect to all factors influencing drug safety and efficacy.
Osnova
  • aVLFA08222c - Pharmacology II practicals

    General medicine

    Spring semester 2020

  • week 24. 2. – 28. 2.
  • 1. DRUGS OF DISEASES WITH CHRONIC PULMONARY OBSTRUCTION, H 1 -ANTIHISTAMINES, COUGH MEDICINES.
  • Content of the lesson: Review of drugs used in the therapy of diseases with chronic pulmonary obstruction, inhalational pharmaceutical forms. Generations of H1 antihistamines and their indications. Cough medicines – classification, modes of action, use in specific subpopulations.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of allergy and diseases with chronic pulmonary obstruction. Content of the lecture. Cough medicines (antitussives and mucoactive drugs).
  • week 2. 3. - 6. 3.
  • 2. ANTIPSYCHOTICS, ANTIPARKINSONICS, PROKINETICS
  • Content of the lesson: Classification of psychotropic medicines, Pharmacology of dopaminergic system with the focus on antipsychotics, antiparkinsonics and prokinetics.
  • Self-study/getting ready for the lesson: Revision of dopamine physiology. Content of the lecture. Prokinetics.
  • week 9. 3. - 12. 3.
  • 3. ANTIDEPRESSANTS
  • Content of the lesson: Pharmacological review of antidepressants, cognitive enhancers and psychostimulants.
  • Self-study/getting ready for the lesson: Content of the lecture. Revision of topic 2., psychostimulants, psychotomimetics.
  • week 16. 3. - 20. 3.
  • 4. ANXIOLYTICS, HYPNOSEDATIVES, ANTICONVULSANTS
  • Content of the lesson: GABAergic neurotransmission. Anxiolytics, hypnosedatives, anticonvulsants – modes of action, drugs, indications, AE including the risk of abuse. Rules in the therapy of sleeping disorders and seizures with respect to specific subpopulations. Psychopharmacological case reports.
  • Self-study/getting ready for the lesson: Revision of TDM. Content of the lecture.
  • week 23. 3. - 27. 3.
  • TEST No. 1
  • 5. ANTI-INFECTIVES I - ANTIBIOTICS
  • Content of the lesson: Pharmacological review of antibiotics, bacterial resistance, respiratory infections, UTI and intensive care antibiotics.
  • Self-study/getting ready for the lesson: Revision of ATB from microbiology (betalactams, macrolides, AMG, TTC, lincosamides, (lipo)glycopeptides, quinolones, sulfonamides, nitroimidazoles, nitrofurans). Content of the lecture.
  • week 30. 3. – 3. 4.
  • 6. ANTI-INFECTIVES II – ANTIMYCOTICS AND ANTIVIRALS
  • Content of the lesson: Dermatologics – classification and pharmacological review, local anti-infectives, revision of drug prescription.
  • Self-study/getting ready for the lesson: Content of the lecture. Dermatologics, antiparasitics.
  • 6. 4. – 10. 4.
  • 7. DRUGS OF GIT
  • Content of the lesson: Pharmacological review of drugs in diseases of GIT.
  • Self-study/getting ready for the lesson: Revision of physiology of GIT, pathophysiology of vomiting and ulcers. Antispasmodics, prokinetics. Content of the lecture. Drugs influencing the production and release of bile.
  • week 13. 4. – 17. 4.
  • 8. CYTOSTATICS AND TARGETED THERAPY IN ONCOLOGY
  • Content of the lesson: Overview, classification and mechanisms of action of anticancer drugs. Adverse effects of cytostatics.
  • Self-study/getting ready for the lesson: Revision of cancer cell biology and the cell cycle phases. Repetition of basic pharmacological principles of targeted therapy. Content of the lecture.
  • week 20. 4. – 24. 4.
  • TEST No. 2
  • 9. ANTIANGIAL DRUGS
  • Content of the lesson: Fundamental of the therapy of angina pectoris and acute myocardial infarction. Direct vasodilating agents, calcium channel blockers, beta blockers, hypolipidemics.
  • Self-study/getting ready for the lesson: Review of pathophysiology of ischemic heart disease, atherosclerosis and myocardial infarction. Content of the lecture. Hypolipidemics, anti-obesity medications.
  • week 27. 4. – 1. 5.
  • 10. ANTIHYPERTENSIVES
  • Content of the lesson: Pharmacological review of antihypertensives with focus on diuretics and drugs targeting RAAS. Combinations of antihypertensives.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of hypertension. Beta blockers, calcium channel blockers. α1 sympatholytics, α2 sympathomimetics. Content of the lecture.
  • week 4. 5. – 8. 5.
  • PRESCRIPTION TEST
  • 11. DRUGS OF HEART FAILURE, ANTIARRHYTHMICS
  • Content of the lesson: Pharmacological review of cardiotonics and other drugs with positive inotropic effect. Medicines of acute and chronic heart failure. Classification and review of antiarrhytmics.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of heart failure and arrythmias. Content of the lecture. Calcium channel blockers, beta blockers, ACEi, local anesthetics.
  • week 11. 5. – 15. 5.
  • 12. DRUGS INFLUENCING HEMOSTASIS
  • Content of the lesson: Classification of drugs interfering with the process of hemostasis, pharmacological review of anticoagulants, antiplatelets, fibrinolytics and antianemics.
  • Self-study/getting ready for the lesson: Revision of hemostasis. Content of the lecture. Antianemics.
  • week 18. 5. – 22. 5.
  • 13. THERAPY OF INTOXICATIONS AND ADDICTION
  • Content of the lesson: Principles of therapy of intoxications and substance addiction. Case reports.
  • Self-study/getting ready for the lesson: Content of the lecture. Substance abuse..
  • week 25. 5. – 29. 5.
  • TEST No. 3
  • 14. DRUG INTERACTIONS
  • Content of the lesson: Students’ presentations – case reports on drug-drug with proposed solution.
  • Self-study/getting ready for the lesson: Pharmacokinetics, pharmacodynamics. Content of the lecture. Collecting of case reports and consultations with professors.
  • week 1. 6. – 5. 6.
  • 15. PHYTOPHARMACOLOGY
  • Content of the lesson: Pharmaceutical forms of herbal medicines, herbal tea mixtures preparation and degustation. Drug-drug interactions of herbal medicines. Herbal self-treatment of selected diseases.
  • Self-study/getting ready for the lesson: Content of the lecture. Drug-drug interactions.
Literatura
    povinná literatura
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    doporučená literatura
  • Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    neurčeno
  • Library of case reports: https://is.muni.cz/auth/do/med/el/case_reports/index_en.html
Výukové metody
Drug classes from the Syllabus are actively reviewed by students and supported by the teacher. Possible ambiguities are discussed and learned knowledge is practiced in case reports from real clinical practice. The training of drug prescription with the use of drug compendia and the computer databases.
Metody hodnocení
The participation in practicals is obligatory and registered. Students can miss two classes without excuse. To get credits a students have to pass 4 written tests:

Prescription test
a) 2 RMP, the indication or pharmacotherapeutic gorup is stated together with a basic data of the patient significant for correct drug selection
Multiple-choice tests
15 questions, number of correct answers indicated, minimal score to pass 6
one of the tests can be repeated once

The credits will be given to students who: passed the prescription test and scored at least 6 points from each of multiple-choice tests and their total score from these tests is higher than 20.
Vyučovací jazyk
Angličtina
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