aVLFA0822c Farmakologie II - cvičení

Lékařská fakulta
jaro 2019
Rozsah
0/3/0. 45. 3 kr. Ukončení: z.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (cvičící)
doc. PharmDr. Jan Juřica, Ph.D. (cvičící)
Mgr. Petra Amchová, Ph.D. (cvičící)
doc. RNDr. Ladislava Bartošová, Ph.D. (cvičící)
Mgr. Jana Kubátová, Ph.D. (cvičící)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (cvičící)
Mgr. Kristýna Nosková, Ph.D. (cvičící)
MUDr. Jana Nováková, Ph.D. (cvičící)
PharmDr. Adriána Papiež, Ph.D. (cvičící)
MUDr. Jana Pistovčáková, Ph.D. (cvičící)
PharmDr. Jitka Rychlíčková, Ph.D. (cvičící)
Mgr. Barbora Říhová, Ph.D. (cvičící)
PharmDr. Lenka Součková, Ph.D. (cvičící)
Filip Šiška (cvičící)
doc. PharmDr. Ondřej Zendulka, Ph.D. (cvičící)
Renata Bláblová (pomocník)
Květoslava Sedlářová (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: doc. PharmDr. Ondřej Zendulka, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav - Teoretická pracoviště - Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLFA0822c/30: Čt 28. 2. 16:00–18:30 A19/229, Čt 7. 3. 16:00–18:30 A19/229, Čt 14. 3. 16:00–18:30 A19/229, Čt 21. 3. 16:00–18:30 A19/229, Čt 28. 3. 16:00–18:30 A19/229, Čt 4. 4. 16:00–18:30 A19/229, Čt 11. 4. 16:00–18:30 A19/229, Čt 18. 4. 16:00–18:30 A19/229, Čt 25. 4. 16:00–18:30 A19/229, Čt 2. 5. 16:00–18:30 A19/229, Čt 9. 5. 16:00–18:30 A19/229, Čt 16. 5. 16:00–18:30 A19/229, Čt 23. 5. 16:00–18:30 A19/229, Čt 30. 5. 16:00–18:30 A19/229, Čt 6. 6. 16:00–18:30 A19/229, L. Součková
aVLFA0822c/31: Čt 28. 2. 16:00–18:30 A19/229, Čt 7. 3. 16:00–18:30 A19/229, Čt 14. 3. 16:00–18:30 A19/229, Čt 21. 3. 16:00–18:30 A19/229, Čt 28. 3. 16:00–18:30 A19/229, Čt 4. 4. 16:00–18:30 A19/229, Čt 11. 4. 16:00–18:30 A19/229, Čt 18. 4. 16:00–18:30 A19/229, Čt 25. 4. 16:00–18:30 A19/229, Čt 2. 5. 16:00–18:30 A19/229, Čt 9. 5. 16:00–18:30 A19/229, Čt 16. 5. 16:00–18:30 A19/229, Čt 23. 5. 16:00–18:30 A19/229, Čt 30. 5. 16:00–18:30 A19/229, Čt 6. 6. 16:00–18:30 A19/229, J. Pistovčáková
aVLFA0822c/32: Pá 1. 3. 13:00–15:30 A19/326, Pá 8. 3. 13:00–15:30 A19/326, Pá 15. 3. 13:00–15:30 A19/326, Pá 22. 3. 13:00–15:30 A19/326, Pá 29. 3. 13:00–15:30 A19/326, Pá 5. 4. 13:00–15:30 A19/326, Pá 12. 4. 13:00–15:30 A19/326, Pá 26. 4. 13:00–15:30 A19/326, Pá 3. 5. 13:00–15:30 A19/326, Pá 10. 5. 13:00–15:30 A19/326, Pá 17. 5. 13:00–15:30 A19/326, Pá 24. 5. 13:00–15:30 A19/326, Pá 31. 5. 13:00–15:30 A19/326, Pá 7. 6. 13:00–15:30 A19/326, O. Zendulka
aVLFA0822c/33: Po 25. 2. 16:00–18:30 A19/229, Po 4. 3. 16:00–18:30 A19/229, Po 11. 3. 16:00–18:30 A19/229, Po 18. 3. 16:00–18:30 A19/229, Po 25. 3. 16:00–18:30 A19/229, Po 1. 4. 16:00–18:30 A19/229, Po 8. 4. 16:00–18:30 A19/229, Po 15. 4. 16:00–18:30 A19/229, Po 29. 4. 16:00–18:30 A19/229, Po 6. 5. 16:00–18:30 A19/229, Po 13. 5. 16:00–18:30 A19/229, Po 20. 5. 16:00–18:30 A19/229, Po 27. 5. 16:00–18:30 A19/229, Po 3. 6. 16:00–18:30 A19/229, J. Pistovčáková
aVLFA0822c/34: Po 25. 2. 13:00–15:30 A19/229, Po 4. 3. 13:00–15:30 A19/229, Po 11. 3. 13:00–15:30 A19/229, Po 18. 3. 13:00–15:30 A19/229, Po 25. 3. 13:00–15:30 A19/229, Po 1. 4. 13:00–15:30 A19/229, Po 8. 4. 13:00–15:30 A19/229, Po 15. 4. 13:00–15:30 A19/229, Po 29. 4. 13:00–15:30 A19/229, Po 6. 5. 13:00–15:30 A19/229, Po 13. 5. 13:00–15:30 A19/229, Po 20. 5. 13:00–15:30 A19/229, Po 27. 5. 13:00–15:30 A19/229, Po 3. 6. 13:00–15:30 A19/229, J. Juřica
Předpoklady
aVLFA0721p Farmakologie I - přednáška && aVLPF0622p Patologická fyziol. II - př
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to acquiant the students with drugs from selected pharmacotherapeutic groups and to learn them how to use the drugs rationally with respect to their mode of action, indications and contraindications.
Výstupy z učení
At the end of the course student should be able choose and prescribe suitable drug for the patient with known indicication. The selection will be made with respect to all factors influencing drug safety and efficacy.
Osnova
  • aVLFA08222c - Pharmacology II practicals

    General medicine

    Spring semester 2019

  • week 25. 2. - 1. 3.
  • 1. ANTIPSYCHOTICS, ANTIPARKINSONICS, PROKINETICS
  • Content of the lesson: Classification of psychotropic medicines, pharmacology of dopaminergic system with the focus on antipsychotics, antiparkinsonics and prokinetics.
  • Self-study/getting ready for the lesson: Revision of dopamine physiology. Content of the lecture. Prokinetics.
  • week 4. 3. - 8. 3.
  • 2. ANXIOLYTICS, HYPNOSEDATIVES, ANTICONVULSANTS
  • Content of the lesson: GABAergic neurotransmission. Anxiolytics, hypnosedatives, anticonvulsants – modes of action, drugs, indications, AE including the risk of abuse. Rules in the therapy of sleeping disorders and seizures with respect to specific subpopulations
  • Self-study/getting ready for the lesson: Revision of TDM, pharmacotherapy in pregnancy. Content of the lecture.
  • week 11. 3. - 15. 3.
  • 3. ANTIDEPRESSANTS
  • Content of the lesson: Pharmacological review of antidepressants and psychostimulants. Neuropsychopharmacological case reports.
  • Self-study/getting ready for the lesson: Content of the lecture. Revision of topics 1 and 2. Psychostimulants, psychotomimetics.
  • week 18. 3. - 22. 3.
  • 4. DRUGS OF DISEASES WITH CHRONIC PULMONARY OBSTRUCTION, H 1-ANTIHISTAMINES, COUGH MEDICINES.
  • Content of the lesson: Review of drugs used in the therapy of diseases with chronic pulmonary obstruction, inhalational pharmaceutical forms. Generations of H1 antihistamines and their indications. Cough medicines – classification, modes of action, use in specific subpopulations.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of allergy and diseases with chronic pulmonary obstruction. Content of the lecture. Cough medicines (antitussives and mucoactive drugs).
  • week 25. 3. - 29. 3.
  • TEST No. 1
  • 5. ANTIANGIAL DRUGS
  • Content of the lesson: Fundamentsal of the therapy of angina pectoris and acute myocardial infarction. Direct vasodilating agents, calcium channel blockers, beta blockers, hypolipidemics.
  • Self-study/getting ready for the lesson: Review of pythophysiology of ischemic heart disease, atherosclerosis and myocardial infarction. Content of the lecture. Hypolipidemics, anti-obesity medications.
  • week 1. 4. – 5. 4.
  • 6. ANTIHYPERTENSIVES
  • Content of the lesson: Pharmacological review of antihypertensives with focus on diuretics and drugs targeting RAAS. Combinations of antihypertensives.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of hypertension. Beta blockers, calcium channel blockers. α1 sympatholytics, α2 sympathomimetics. Content of the lecture.
  • week 8. 4. – 12. 4.
  • 7. DRUGS OF HEART FAILURE, ANTIARRHYTHMICS
  • Content of the lesson: Pharmacological review of cardiotonics and other drugs with positive inotropic effect. Medicines of acute and chronic heart failure. Classification and review of antiarrhytmics.
  • Self-study/getting ready for the lesson: Revision of pathophysiology of heart failure and arrythmias. Content of the lecture. Calcium channel blockers, beta blockers, ACEi, local anesthetics.
  • week 15. 4. – 19. 4.
  • 8. DRUGS INFLUENCING HEMOSTASIS
  • Content of the lesson: Classification of drugs interfering with the process of hemostasis, pharmacological review of anticoagulants, antiplatelets, fibrinolytics and antianemics.
  • Self-study/getting ready for the lesson: Revision of hemostasis. Content of the lecture. Antianemics.
  • week 22. 4. – 26. 4.
  • TEST No. 2
  • 9. ANTI-INFECTIVES I - ANTIBIOTICS
  • Content of the lesson: Pharmacological review of antibiotics, bacterial resistance, respiratory infections, UTI and intensive care antibiotics.
  • Self-study/getting ready for the lesson: Revision of ATB from microbiology (betalactams, macrolides, AMG, TTC, lincosamides, (lipo)glycopeptides, quinolones, sulfonamides, nitroimidazoles, nitrofurans). Content of the lecture.
  • week 29. 4. – 3. 5.
  • 10. ANTI-INFECTIVES II – ANTIMYCOTICS AND ANTIVIRALS
  • Content of the lesson: Dermatologics – classification and pharmacological review, local anti-infectives, revision of drug prescription.
  • Self-study/getting ready for the lesson: Content of the lecture. Dermatologics, antiparasitics.
  • week 6. 5. – 10. 5.
  • 11. DRUGS OF GIT
  • Content of the lesson: Pharmacological review of drugs in diseases of GIT.
  • Self-study/getting ready for the lesson: Revision of physiology of GIT, pathophysiology of vomiting and ulcers. Antispasmodics, prokinetics. Content of the lecture. Drugs influencing the production and release of bile.
  • week 13. 5. – 17. 5.
  • 12. CYTOSTATICS AND TARGETED THERAPY IN ONCOLOGY
  • Content of the lesson: Overview, classification and mechanisms of action of anticancer drugs. Adverse effects of cytostatics.
  • Self-study/getting ready for the lesson: Revision of cancer cell biology and the cell cycle phases. Repetition of basic pharmacological principles of targeted therapy. Content of the lecture.
  • week 20. 5. – 24. 5.
  • TEST Rp.
  • 13. THERAPY OF INTOXICATIONS
  • Content of the lesson: Principles of therapy of intoxications. Case reports on drug intoxications.
  • Self-study/getting ready for the lesson: Content of the lecture. Substance abuse.
  • week 27. 5. – 31. 5.
  • TEST No. 3
  • 14. DRUG INTERACTIONS
  • Content of the lesson: Students’ presentations – case reports on drug-drug interactions from clinical courses with proposed solution.
  • Self-study/getting ready for the lesson: Pharmacokinetics, pharmacodynamics. Content of the lecture. Collecting of case reports during clinical courses and consultations with professors.
  • week 3. 6. – 7. 6.
  • 15. PHYTOPHARMACOLOGY
  • Content of the lesson: Pharmaceutical forms of herbal medicines, herbal tea mixtures preparation and degustation. Drug-drug interactions of herbal medicines. Herbal self-tretament of selected diseases.
  • Self-study/getting ready for the lesson: Content of the lecture. Drug-drug interactions.
Literatura
    povinná literatura
  • RANG, H. P., James RITTER, R. J. FLOWER a Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    doporučená literatura
  • Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    neurčeno
  • Library of case reports: https://is.muni.cz/auth/do/med/el/case_reports/index_en.html
Výukové metody
Drug classes specifics from the Syllabus are firstly briefly reviewed by the teacher, the discussion on possible ambiguities are discussed and learned knowledge is practicesed in case reports from real clinical practice. The training of drug prescription with the use of drug compendia and the computer databases.
Metody hodnocení
The participation in practicals is obligatory and registered. Students can miss one class without excuse. To get credits a students have to pass 4 written tests:

Prescription test
a) 2 RMP, the indication or pharmacotherapeutic gorup is stated together with a basic data of the patient significant for correct drug selection
Multiple-choice tests
15 questions, number of correct answers indicated, minimal score to pass 6
one of the tests can be repeated once

The credits will be given to students who: passed the prescription test and scored at least 6 points from each of multiple-choice tests and their total score from these tests is higher than 20.
Vyučovací jazyk
Angličtina
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