Výpis publikací

BOSÁKOVÁ, Michaela; Sara POOVAKULATHU ABRAHAM; Davis WACHTELL; Jennifer T ZIEBA; Alexander KOT; Alexandru NITĂ; Aleksandra Anna CZYREK; Adolf KOUDELKA; Vlad-Constantin URSACHI; Zuzana FEKETOVÁ; Gustavo RICO-LLANOS; Kateřina SVOZILOVÁ; Petra KOCEROVÁ; Bohumil FAFÍLEK; Tomáš GREGOR; Jana KOTAŠKOVÁ; Ivan DURAN; Petr VAŇHARA; Michael DOUBEK; Jiří MAYER; Karel SOUČEK; Deborah KRAKOW a Pavel KREJČÍ. Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors. Cell Communication and Signaling. LONDON: BMC, 2025, roč. 23, č. 1, s. 1-17. ISSN 1478-811X. Dostupné z: https://doi.org/10.1186/s12964-025-02208-w.

NITĂ, Alexandru; Sara POOVAKULATHU ABRAHAM; Eman ELREFAAY; Bohumil FAFÍLEK; Eliška ČÍŽKOVÁ; Vlad-Constantin URSACHI; Iva GUDERNOVÁ; Adolf KOUDELKA; Pooja DUDEJA; Tomáš GREGOR; Zuzana FEKETOVÁ; Gustavo Adolfo RICO LLANOS; Kateřina SVOZILOVÁ; Canan ÇELIKER; Aleksandra Anna CZYREK; Tomáš BÁRTA; Lukáš TRANTÍREK; Antoni WIEDLOCHA; Pavel KREJČÍ a Michaela BOSÁKOVÁ. FGFR2 residence in primary cilia is necessary for epithelial cell signaling. Journal of cell biology. NEW YORK: ROCKEFELLER UNIV PRESS, 2025, roč. 224, č. 7, s. 1-21. ISSN 0021-9525. Dostupné z: https://doi.org/10.1083/jcb.202311030.

CZYREK, Aleksandra Anna; Karolina BARAN; Eva HRUBÁ; Aneta HORACKOVA; Veronika BOSÁKOVÁ; Julia CHUDZIAN; Bohumil FAFÍLEK; Veronika LASKOVA; Veronika STEPANKOVA; David BEDNÁŘ; Kelly KARL; Petr KASPAREK; Michaela BOSÁKOVÁ; Michal KILLINGER; Tereza SZOTKOWSKA; Jan PROCHAZKA; Jennifer T ZIEBA; Gustavo RICO LLANOS; Jan FRIČ; Stefan HADZIC; Edma LOKU; Magdalena WUJAK; Kateřina SVOZILOVÁ; Michaela STROBLOVÁ; Radislav SEDLACEK; Kalina HRISTOVA; Deborah KRAKOW; Jan KUBOVCIAK; Mathys DELATTRE; Rafal BARTOSZEWSKI; Marcela BUCHTOVÁ; Daniel KROWARSCH; Radka CHALOUPKOVÁ; Malgorzata ZAKRZEWSKA a Pavel KREJČÍ. Increased thermal stability of FGF10 leads to ectopic signaling during development. Cellular and molecular life sciences. BASEL: SPRINGER BASEL AG, 2025, roč. 82, č. 1, s. 1-24. ISSN 1420-682X. Dostupné z: https://doi.org/10.1007/s00018-025-05681-1.

RYNEŠ, Jan; Eva IŠTVÁNKOVÁ; Michaela KRAFČÍKOVÁ; Enrico LUCHINAT; Letizia BARBIERI; Lucia BANCI; Kristýna KAMARÝTOVÁ; Tomáš LOJA; Bohumil FAFÍLEK; Gustavo RICO LLANOS; Pavel KREJČÍ; Libor MACUREK; Silvie TRANTÍRKOVÁ a Lukáš TRANTÍREK. Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models. Communications Biology. BERLIN: Nature Research, 2025, roč. 8, č. 1, s. 1-9. ISSN 2399-3642. Dostupné z: https://doi.org/10.1038/s42003-025-07607-w.

ZLÍNSKÁ, Vladimíra; Zuzana FEKETOVÁ; Aleksandra Anna CZYREK; Julia CHUDZIAN; Martina Lenarcic ZIVKOVIC; Vlad-Constantin URSACHI; Pooja DUDEJA; Bohumil FAFÍLEK; Jan RYNEŠ; Gustavo RICO LLANOS; Adolf KOUDELKA; Tanaya ROY; Martyna BIADUN; Vendula RAŠKOVÁ; Kateřina SVOZILOVÁ; Michaela STROBLOVÁ; Mateusz KRZYSCIK; Kalina HRISTOVA; Daniel KROWARSCH; Silvie TRANTÍRKOVÁ; Malgorzata ZAKRZEWSKA; Lukáš TRANTÍREK a Pavel KREJČÍ. Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer. MOLECULAR THERAPY-NUCLEIC ACIDS. Cambridge: CELL PRESS, 2025, roč. 36, č. 1, s. 1-10. ISSN 2162-2531. Dostupné z: https://doi.org/10.1016/j.omtn.2024.102405.

RICO LLANOS, Gustavo; Frantisek SPOUTIL; Eva BLAHOVÁ; Adolf KOUDELKA; Michaela PROCHAZKOVA; Aleksandra Anna CZYREK; Bohumil FAFÍLEK; Jan PROCHAZKA; Marcos GONZÁLEZ LÓPEZ; Jan KŘIVÁNEK; Radislav SEDLACEK; Deborah KRAKOW; Yosuke NONAKA; Yoshikazu NAKAMURA a Pavel KREJČÍ. Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy. Journal of bone and mineral research. Hoboken: Wiley, 2024, roč. 39, č. 12, s. 1783-1792. ISSN 0884-0431. Dostupné z: https://doi.org/10.1093/jbmr/zjae173.

NĚMEC, Václav; Marek REMEŠ; Petr BEŇOVSKÝ; Michael Christopher BÖCK; Eliška ŠRANKOVÁ; Jong Fu WONG; Cros JULIEN; Eleanor WILLIAMS; Lap Hang TSE; David SMIL; Deeba ENSAN; Methvin B ISAAC; Rima AL-AWAR; Regína GOMOLKOVÁ; Vlad-Constantin URSACHI; Bohumil FAFÍLEK; Zuzana KAHOUNOVA; Rachel VICHOVA; Ondrej VACEK; Benedict-Tilman BERGER; Carrow I WELLS; Cesear R CORONA; James D VASTA; Matthew B ROBERS; Pavel KREJČÍ; Karel SOUČEK; Alex N BULLOCK; Stefan KNAPP a Kamil PARUCH. Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of Medicinal Chemistry. Washington: American Chemical Society, 2024, roč. 67, č. 15, s. 12632-12659. ISSN 0022-2623. Dostupné z: https://doi.org/10.1021/acs.jmedchem.4c00629.

KARL, Kelly; Del Piccolo NUALA; Taylor LIGHT; Tanaya ROY; Pooja DUDEJA; Vlad-Constantin URSACHI; Bohumil FAFÍLEK; Pavel KREJČÍ a Kalina HRISTOVA. Ligand bias underlies differential signaling of multiple FGFs via FGFR1. elife. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2024, roč. 12, April 2024, s. 1-28. ISSN 2050-084X. Dostupné z: https://doi.org/10.7554/eLife.88144.

FAFÍLEK, Bohumil; Michaela BOSÁKOVÁ a Pavel KREJČÍ. Expanding horizons of achondroplasia treatment: current options and future developments. Osteoarthritis and Cartilage. Oxford: Elsevier, 2022, roč. 30, č. 4, s. 535-544. ISSN 1063-4584. Dostupné z: https://doi.org/10.1016/j.joca.2021.11.017.

WEISSOVÁ, Kamila; Bohumil FAFÍLEK; Tomasz Witold RADASZKIEWICZ; Canan ÇELIKER; Petra MACHÁČKOVÁ; Tamara ČECHOVÁ; Jana ŠEBESTÍKOVÁ; Aleš HAMPL; Vítězslav BRYJA; Pavel KREJČÍ a Tomáš BÁRTA. LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters. Life science alliance. COLD SPRING HARBOR: LIFE SCIENCE ALLIANCE LLC, 2022, roč. 5, č. 8, s. 1-9. ISSN 2575-1077. Dostupné z: https://doi.org/10.26508/lsa.202201421.

DURAN, I.; J. ZIEBA; F. CSUKASI; J. H. MARTIN; D. WACHTELL; M. BARAD; B. DAWSON; Bohumil FAFÍLEK; C. M. JACOBSEN; C. G. AMBROSE; D. H. COHN; Pavel KREJČÍ; B. H. LEE a D. KRAKOW. 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta. Journal of bone and mineral research. Hoboken: Wiley, 2022, roč. 37, č. 4, s. 675-686. ISSN 0884-0431. Dostupné z: https://doi.org/10.1002/jbmr.4501.

KIMURA, T.; Michaela BOSÁKOVÁ; Y. NONAKA; Eva HRUBA; K. YASUDA; S. FUTAKAWA; T. KUBOTA; Bohumil FAFÍLEK; Tomáš GREGOR; Sara POOVAKULATHU ABRAHAM; Regína GOMOLKOVÁ; Silvie BELASKOVA; Martin PEŠL; F. CSUKASI; I. DURAN; M. FUJIWARA; Michaela KAVKOVA; Tomas ZIKMUND; Josef KAISER; Marcela BUCHTOVÁ; D. KRAKOW; Y. NAKAMURA; K. OZONO a Pavel KREJČÍ. An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice. Science Translational Medicine. Washington: American Association for the Advancement of Science, 2021, roč. 13, č. 592, s. "eaba4226", 14 s. ISSN 1946-6234. Dostupné z: https://doi.org/10.1126/scitranslmed.aba4226.

GREGOR, Tomáš; Michaela BOSÁKOVÁ; Alexandru NITĂ; Sara POOVAKULATHU ABRAHAM; Bohumil FAFÍLEK; Nicole ČERNOHORSKÁ; Jan RYNEŠ; Silvie TRANTÍRKOVÁ; Daniela ŽÁČKOVÁ; Jiří MAYER; Lukáš TRANTÍREK a Pavel KREJČÍ. Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex. Cellular and molecular life sciences. BASEL: SPRINGER BASEL AG, 2020, roč. 77, č. 19, s. 3885-3903. ISSN 1420-682X. Dostupné z: https://doi.org/10.1007/s00018-019-03397-7.

BOSÁKOVÁ, Michaela; Alexandru NITĂ; Tomáš GREGOR; Miroslav VAŘECHA; Iva GUDERNOVÁ; Bohumil FAFÍLEK; Tomáš BÁRTA; Neha BASHEER; Sara POOVAKULATHU ABRAHAM; Lukáš BÁLEK; Markéta TOMANOVÁ; Jana FIALOVÁ KUČEROVÁ; Juraj BOSÁK; David POTĚŠIL; Jennifer ZIEBA; Jieun SONG; Peter KONIK; Sohyun PARK; Ivan DURAN; Zbyněk ZDRÁHAL; David ŠMAJS; Gert JANSEN; Zheng FU; Hyuk Wan KO; Aleš HAMPL; Lukáš TRANTÍREK; Deborah KRAKOW a Pavel KREJČÍ. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: NATL ACAD SCIENCES, 2019, roč. 116, č. 10, s. 4316-4325. ISSN 0027-8424. Dostupné z: https://doi.org/10.1073/pnas.1800338116.

FAFÍLEK, Bohumil; Lukáš BÁLEK; Michaela BOSÁKOVÁ; Miroslav VAŘECHA; Alexandru NITĂ; Tomáš GREGOR; Iva GUDERNOVÁ; Jitka KŘENOVÁ; S. GHOSH; Martin PISKÁČEK; Lucie JONATOVA; Nicole ČERNOHORSKÁ; J.T. ZIEBA; M. KOSTAS; E.M. HAUGSTEN; J. WESCHE; C. ERNEUX; Lukáš TRANTÍREK; D. KRAKOW a Pavel KREJČÍ. The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. SCIENCE SIGNALING. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2018, roč. 11, č. 548, s. 1-14. ISSN 1945-0877. Dostupné z: https://doi.org/10.1126/scisignal.aap8608.

GUDERNOVÁ, Iva; Lukáš BÁLEK; Miroslav VAŘECHA; Jana FIALOVÁ KUČEROVÁ; Michaela BOSÁKOVÁ; Bohumil FAFÍLEK; Veronika PALUŠOVÁ; Stjepan ULDRIJAN; Lukáš TRANTÍREK a Pavel KREJČÍ. Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480. Oncotarget. New York: Impact Journals LLC, 2017, roč. 8, č. 65, s. 109319-109331. ISSN 1949-2553. Dostupné z: https://doi.org/10.18632/oncotarget.22674.

GUDERNOVÁ, Iva; Silvie TRANTÍRKOVÁ; Barbora EL GHANNAMOVÁ; Bohumil FAFÍLEK; Miroslav VAŘECHA; Lukáš BÁLEK; Eva HRUBÁ; Lucie JONÁTOVÁ; Iva JELÍNKOVÁ; Michaela BOSÁKOVÁ; Lukáš TRANTÍREK; Jiří MAYER a Pavel KREJČÍ. One reporter for in-cell activity profiling of majority of protein kinase oncogenes. eLife. Cambridge: eLife Sciences Publications Ltd., 2017, roč. 6, "e21536", s. 1-14. ISSN 2050-084X. Dostupné z: https://doi.org/10.7554/eLife.21536.

FAFÍLEK, Bohumil; Marek HAMPL; Nikola ŘIČÁNKOVÁ; I. VESELA; Lukáš BÁLEK; Michaela BOSÁKOVÁ; Iva GUDERNOVÁ; Miroslav VAŘECHA; marcela BUCHTOVÁ a Pavel KREJČÍ. Statins do not inhibit the FGFR signaling in chondrocytes. Osteoarthritis and Cartilage. Oxford: Elsevier Science Inc., 2017, roč. 25, č. 9, s. 1522-1530. ISSN 1063-4584. Dostupné z: https://doi.org/10.1016/j.joca.2017.05.014.

JANECKOVA, L; Bohumil FAFÍLEK; M KRAUSOVA; M HORAZNA; M VOJTECHOVA; M ALBERICH-JORDA; E SLONCOVA; K GALUSKOVA; R SEDLACEK; M ANDEROVA a V KORINEK. Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity. GENESIS. MALDEN: WILEY-BLACKWELL, 2016, roč. 54, č. 3, s. 101-114. ISSN 1526-954X. Dostupné z: https://doi.org/10.1002/dvg.22922.

JANECKOVA, L; Vendula POSPÍCHALOVÁ; Bohumil FAFÍLEK; M VOJTECHOVA; J TURECKOVA; J DOBES; M DUBUISSEZ; D LEPRINCE; N BALOGHOVA; M HORAZNA; A HLAVATA; J STANCIKOVA; E SLONCOVA; K GALUSKOVA; H STRNAD a V KORINEK. HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-kappa B Signaling and Promotes Tissue Damage-Associated Tumorigenesis. MOLECULAR CANCER RESEARCH. PHILADELPHIA: AMER ASSOC CANCER RESEARCH, 2015, roč. 13, č. 7, s. 1139-1148. ISSN 1541-7786. Dostupné z: https://doi.org/10.1158/1541-7786.MCR-15-0033.

STANCIKOVA, J; M KRAUSOVA; M KOLAR; Bohumil FAFÍLEK; J SVEC; R SEDLACEK; M NEROLDOVA; J DOBES; M HORAZNA; L JANECKOVA; M VOJTECHOVA; M OLIVERIUS; Milan JIRSA a V KORINEK. NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling. Cellular Signalling. NEW YORK: ELSEVIER SCIENCE INC, 2015, roč. 27, č. 2, s. 245-256. ISSN 0898-6568. Dostupné z: https://doi.org/10.1016/j.cellsig.2014.11.008.

MUCKSOVA, J; J KALINA; M BAKST; H YAN; JP BRILLARD; B BENESOVA; Bohumil FAFÍLEK; J HEJNAR a P TREFIL. Expression of the chicken GDNF family receptor alpha-1 as a marker of spermatogonial stem cells. ANIMAL REPRODUCTION SCIENCE. AMSTERDAM: ELSEVIER SCIENCE BV, 2013, roč. 142, 1-2, s. 75-83. ISSN 0378-4320. Dostupné z: https://doi.org/10.1016/j.anireprosci.2013.08.006.

FAFÍLEK, Bohumil; M KRAUSOVA; M VOJTECHOVA; Vendula POSPÍCHALOVÁ; L TUMOVA; E SLONCOVA; M HURANOVA; J STANCIKOVA; A HLAVATA; J SVEC; R SEDLACEK; O LUKSAN; M OLIVERIUS; Ivan VOSKA; Milan JIRSA; J PACES; M KOLAR; M KRIVJANSKA; K KLIMESOVA; H TLASKALOVA-HOGENOVA a V KORINEK. Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells. Gastroenterology. Philadelphia: W B Saunders co-Elsevier Inc, 2013, roč. 144, č. 2, s. 381-391. ISSN 0016-5085. Dostupné z: https://doi.org/10.1053/j.gastro.2012.10.048.

DOUBRAVSKA, L; M KRAUSOVA; D GRADL; M VOJTECHOVA; L TUMOVA; J LUKAS; T VALENTA; Vendula POSPÍCHALOVÁ; Bohumil FAFÍLEK; J PLACHY; O SEBESTA a V KORINEK. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cellular Signalling. NEW YORK: ELSEVIER SCIENCE INC, 2011, roč. 23, č. 5, s. 837-848. ISSN 0898-6568. Dostupné z: https://doi.org/10.1016/j.cellsig.2011.01.007.

POSPÍCHALOVÁ, Vendula; J TURECKOVA; Bohumil FAFÍLEK; M VOJTECHOVA; M KRAUSOVA; J LUKAS; E SLONCOVA; Sylvia TAKÁČOVÁ; Vladimír DIVOKÝ; D LEPRINCE; J PLACHY a V KORINEK. Generation of Two Modified Mouse Alleles of the Hic1 Tumor Suppressor Gene. GENESIS. MALDEN: WILEY-BLACKWELL, 2011, roč. 49, č. 3, s. 142-151. ISSN 1526-954X. Dostupné z: https://doi.org/10.1002/dvg.20719.

LUKAS, J; P MAZNA; T VALENTA; L DOUBRAVSKA; Vendula POSPÍCHALOVÁ; M VOJTECHOVA; Bohumil FAFÍLEK; R IVANEK; J PLACHY; J NOVAK a V KORINEK. Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Research. Oxford, UK: Oxford Press, 2009, roč. 37, č. 9, s. 3007-3020. ISSN 0305-1048. Dostupné z: https://doi.org/10.1093/nar/gkp179.

VALENTA, T; J LUKAS; L DOUBRAVSKA; Bohumil FAFÍLEK a V KORINEK. HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO Journal. Hoboken (USA): WILEY-BLACKWELL, 2006, roč. 25, č. 11, s. 2326-2337. ISSN 0261-4189. Dostupné z: https://doi.org/10.1038/sj.emboj.7601147.