aZLFA0722p Farmakologie II - přednáška

Lékařská fakulta
podzim 2025
Rozsah
1/0/0. 15. 2 kr. Ukončení: zk.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (přednášející)
doc. PharmDr. Jan Juřica, Ph.D. (přednášející)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (přednášející)
MUDr. Alena Máchalová, Ph.D. (přednášející)
Carlos Daniel Ferreira Fonseca, MSc. (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Po 22. 9. 19:30–21:10 Virtuální místnost, Po 29. 9. 19:30–21:10 Virtuální místnost, Po 6. 10. 19:30–21:10 Virtuální místnost, Po 13. 10. 19:30–21:10 Virtuální místnost, Po 20. 10. 19:30–21:10 Virtuální místnost, Po 27. 10. 19:30–21:10 Virtuální místnost, Po 3. 11. 19:30–21:10 Virtuální místnost, Po 10. 11. 19:30–21:10 Virtuální místnost
Předpoklady
aZLFA0621c Farmakologie I - cvičení && aZLPA0622c Patologie II - cvičení && aZLPF0622c Patol. fyziologie II -cvičení && aZLOR0641c Ortodoncie I - cvičení && aZLPD0631c Parodontologie I - cvičení
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
At the end of the course students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum.
Výstupy z učení
Students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum with the special attention paid to preparations used in dentistry.
Osnova
  • 1. ANALGESICS, PHARMACOTHERAPY OF MIGRAINE AND GOUT. Classification of analgesics. Basic pharmacological characteristics and examples of the use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretics. Basic principles of pain therapy, co-analgesics. Drugs used in the treatment of migraine and gout.
  • 2. PSYCHOPHARMACOLOGY. Basic pharmacological characteristics of antipsychotics, antiparkinsonian drugs, antidepressants, psychostimulants, anxiolytics, hypnosedatives and anticonvulsants.
  • 3. GENERAL AND LOCAL ANAESTHETICS, MUSCLE RELAXANTS. Classification and basic pharmacological characteristics of general and local anaesthetics and muscle relaxants. Overview of drugs used in premedication and post-anaesthetic care.
  • 4. ANTI-INFECTIVES – ANTIBIOTICS, ANTIMYCOTICS AND ANTIVIROTICS. Principles of rational antimicrobial therapy, bacterial resistance, pharmacological overview of antibiotics, antimycotics and antivirotics.
  • 5. ORAL CAVITY MEDICINES. Summary of general principles. Overview of individual groups and representatives. Pharmacotherapy of selected oral cavity diseases. Phytotherapy in dentistry.
  • 6. DRUGS AFFECTING CARDIOVASCULAR SYSTEM I. Drug groups affecting RAAS (ACEi, sartans, kirens), diuretics, aldosterone antagonists and mineralocorticoid receptor antagonists. First- and second-line antihypertensive drugs, combinations of antihypertensive drugs, vasodilators (calcium channel blockers, nitrates and NO donors).
  • 7. DRUGS AFFECTING CARDIOVASCULAR SYSTEM II AND BLOOD. Positive inotropics and antiarrhythmics. Pharmacological profiles of drugs from the groups of anticoagulants, antiplatelet drugs, fibrinolytics, antifibrinolytics and haemostatics.
  • 8. PHARMACOTHERAPY OF CANCER. Introduction, principles of cytostatic therapy, overview of mechanisms of tumour resistance, importance of genotyping of polymorphisms and TDM in oncology, basic groups of cytostatics/classification according to their mechanism of action, basic pharmacological overview. Principles of targeted therapy in oncology – monoclonal antibodies, tyrosine kinase inhibitors, targeted immunotherapy.
Literatura
    povinná literatura
  • RITTER, James; R. J. FLOWER; Graeme HENDERSON; Yoon Kong LOKE; David J. MACEWAN; Emma S. J. ROBINSON a James FULLERTON. Rang & Dale's pharmacology / James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEvan, Emma Robinson, James Fullerton. Tenth edition. London: Elsevier, 2024, xvii, 850. ISBN 9780323873963. info
    neurčeno
  • Lippincott's Illustrated Reviews : Pharmacology, 4th Ed., Harvey, Richard A. - Champe, Pamela C. - Finkel, Richard - Cubeddu, Luigi - Clarke, Michelle A. 2008. 560 s. ISBN-10: 0-7817-7155-2, ISBN-13: 978-0-7817-7155-9
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
Záložky
https://is.muni.cz/ln/tag/LF:aZLFA0722p!
Výukové metody
Presentatios of lectures will be provided in e-form as commented presentations. Students are expected to follow the provided lectures.
Metody hodnocení
The final exam will be in the form of ROPOT test followed by oral examination.
Vyučovací jazyk
Angličtina
Informace učitele
Information for students:


Students are requested to answer three randomly chosen questions of the following list and additional questions of the examiner.




QUESTIONS ON GENERAL PHARMACOLOGY:


1. Pharmacology, sub-branches, origin of drugs, drug names, types of pharmacotherapy. •


2. Drugs life cycle. •


3. Basic legislation related to drug use, rules for drug prescription. •


4. Routes of drug administration – overview, characteristics. •


5. Drug dosage forms - overview. •


6. Drug absorption and distribution + factors affecting these processes. •


7. Drug elimination + factors affecting these processes. •


8. Single, repeated and continual drug administration + factors affecting plasma concentration of drugs. •


9. Non-receptor mechanisms of action, types of doses. •


10. Receptor theory of mechanisms of action, relation dose – response.


11. Safety of drugs, principles of rational pharmacotherapy. •


12. Adverse drug reactions. •


13. Factors affecting the drug effect and effect of concomitant diseases on drug effects. •


14. Pharmacotherapy in pregnancy, in breastfeeding women and in paediatric population. •


15. Pharmacotherapy in elderly, pharmacogenetics. •


16. Principles of biological therapy. •


17. Drug interactions. •




QUESTIONS ON SPECIAL PHARMACOLOGY:


1. Cholinomimetics •


2. Parasympatholytics •


3. Sympathomimetics •


4. Sympatholytics •


5. Hypolipidaemics, anti-obesity drugs •


6. Antiasthmatics, other drugs used in diseases with chronic bronchial obstruction •


7. Antitussives, mucoactive drugs •


8. Analogues and antagonists of sex hormones •


9. Drugs used in osteoporosis, pharmacology of thyroid gland •


10. Antiulcer agents, antiemetic drugs, prokinetics •


11. Laxatives, antidiarrhoics, spasmolytics •


12. Antimigraine agents, antiuratics •


13. Antipsychotics •


14. Antiparkinsonics •


15. Nootropics, cognitive enhancers, psychostimulants •


16. Antidepressants •


17. Anticonvulsants •


18. Muscle relaxants •


19. Aminoglycosides, tetracyclines, glycopeptides, polymyxins •


20. Sulphonamides, nitrofurans, amphenicols, fluoroquinolones, ansamycines •


21. Antivirotics •


22. Vasodilators •


23. Drugs targeting RAAS, diuretics, antagonists of aldosterone •


24. Beta blockers + central antihypertensives •


25. Positive inotropic drugs and antiarrhythmics •


26. Cytostatics •


27. Adverse effects of antitumor therapy •


28. Targeted and hormonal treatment in oncology •


SELECTED TOPICS ON SPECIAL PHARMACOLOGY:


1. Antidiabetics •


2. Glucocorticoids •


3. H1 antihistamines •


4. Opioid analgesics •


5. NSAIDs, antipyretics •


6. Hypnosedatives •


7. Anxiolytics •


8. General anaesthetics •


9. Local anaesthetics •


10. Principles of antibacterial therapy, local antibiotics •


11. Beta-lactam antibiotics •


12. Macrolides, lincosamides, oxazolidinones, nitroimidazoles •


13. Antimycotics •


14. Drugs used in oral cavity, antiseptic drugs •


15. Antiplatelet agents, fibrinolytics, antifibrinolytics, haemostatics •


16. Anticoagulants •

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