VLFA0722c Pharmacology II - practice

Faculty of Medicine
autumn 2018
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
PharmDr. Adriána Papiež, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
VLFA0621c Pharmacology I - p && ( VSAJ0222 English 1 II -p || VLAJ0222 English 1 II -p || VSCJ0686 Czech for Foreigners VI -p || VSNJ0222 German 1 II -p || VSSJ0222 Spanish 1 II -p )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student should be able to prescribe representatives of individual drug classes in the form of individually prepared pharmaceutical preparation and bulk drugs. The student should be familiar with pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions.
Learning outcomes
At the end of the course student should be able to prescribe representatives of individual drug classes in the form of individually prepared pharmaceutical preparation and bulk drugs. The student should be familiar with pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions.
Syllabus
  • VLFA07212c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2018

  • 1st week
  • Topic: INFORMATION ON DRUGS
  • Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 1 and the Chapter 1.1 in the textbook Nováková J. a kol. - Latin terminology, Pharmacological calculations with the use of the textbook for Practical lessons.
  • 2nd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS I
  • Course content: General rules of drug prescription. Prescription of the individually-made solid, liquid and semi-solid pharmaceutical dosage forms.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 2. Drug dosage forms from the textbook. Legislation of the Czech Republic related to drugs and their prescription (selected section of the Act No. 378/2007 Coll., on Pharmaceuticals and on Amendments to Some Related Acts).
  • 3rd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS II, ROUTES OF DRUG ADMINISTRATION
  • Course content: Brief characteristics of the individual drug dosage forms. Prescription of ready-made drug products. Clinical significance of the way of drug administration.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 3. Information in drug databases - SÚKL (www.sukl.cz), EMA and Drugs.com.
  • 4th week
  • Topic: PRINCIPLES OF PHARMACOKINETICS
  • Course content: Pharmacokinetic processes, parameters and calculations.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 4.
  • 5th week
  • Topic: PRINCIPLES OF APPLIED PHARMACOKINETICS
  • Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5.
  • 6th week
  • Topic: PHARMACODYNAMICS
  • Course content: Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 6.
  • 7th week
  • Topic: ADVERSE DRUG REACTIONS
  • Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety. Databases of drug interactions. Pharmaceutical interactions (case reports).
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 7, case report (drug incompatibility) materials in IS.
  • 8th week
  • Topic: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Pharmacogenetics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Pharmacogenetics - materials in IS.
  • 9th week
  • Topic: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
  • 10th week
  • Topic: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs.
  • 11th week
  • Topic: GLUCOCORTICOIDS, DRUGS OF ABUSE
  • Course content: Repetition of basic pharmacological characteristics of glucocorticoids. Problems of drug abuse, doping and falsification of medical products.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 11, preparation of oral presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 12th week
  • Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 12, preparation of oral presentation - presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 13th week
  • Topic: SEX HORMONES
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 13. Uterotonics and tocolytics.
  • 14th week
  • Topic: ANALGESIC DRUGS
  • Course content: Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and antiuratic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 14. Antirheumatoid and antiuratic drugs.
  • 15th week
  • Topic: ANAESTHETIC DRUGS
  • Course content: PRESCRIPTION TEST. Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Muscle relaxants.
  • ----------------------------------------------------------------------------------------------------------------------------------------
  • VLFA0722c Pharmacology II- practicals

    Autumn semester 2017

  • Day 1 (Monday)
  • Introduction, instructions. Distribution of co-talks.
  • 1/ANALGESICS.
  • Opioid analgesics. Pharmacotherapy of pain. Opioid addiction therapy. Prescription and practical use of analgesic preparations.
  • 2/NON-STEROIDAL ANTIINFLAMMATORY DRUGS, DRUGS USED IN GOUT, ANTIPYRETICS.
  • Mechanisms of action and classification of anti-inflammatory drugs. Drugs used in therapy of gout.
  • Getting ready for the next lesson: Central neurotransmitters and sites of drug effects in CNS. Basic psychical functions.
  • Day 2 (Tuesday)
  • 3/ANTIDEPRESSANTS.
  • Classification and terminology of antidepressants. Review of their mechanisms of action, adverse effects, interactions.
  • Co-talks.
  • 4/THERAPY OF ANXIETY, HYPNOSEDATIVES.
  • Classification and terminology of psychotropics. Review of their mechanisms of action. Pharmacology of anxiolytics and hypnosedatives. Mechanism of action of benzodiazepines. Prescription of hypnosedatives and psychostimulants.
  • Co-talks.
  • Getting ready for the next lesson: Pathophysiology of cancer disease
  • Day 3 (Wednesday)

    No classes.

  • Day 4 (Thursday)
  • REVISING TEST I (Revision test with subsequent discussion) Lesson 1 – 4.
  • 5/CASE REPORTS I.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • 6/ PHARMACOLOGY OF ANTICANCER DRUGS.
  • Classification, mechanisms of action, side effects.
  • Co-talks.
  • Getting ready for the next lesson: Structure of bacterial cell, basis of antimicrobial therapy.
  • Day 5 (Friday)
  • 7/ANTIMICROBIAL AGENTS I.
  • Classification, mechanisms of action, combinations of antibiotics and chemotherapeutics.
  • Co-talks.
  • 8/ANTIMICROBIAL AGENTS II., THERAPY OF INFECTIOUS DIARRHEAS AND UROINFECTIONS.
  • Drugs for the treatment of intestinal and urinary infections.
  • Co-talks.
  • Getting ready for the next lesson: Autonomic nervous system – catecholamines, atropine. Muscle relaxants.
  • Day 6 (Monday)
  • REVISING TEST II (Overhead-test with subsequent discussion). Lessons 5 - 8.
  • 9/CASE REPORTS II.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • Co-talks.
  • 10/GENERAL AND LOCAL ANAESTHETICS
  • Combined and balanced anaesthesia. Signs and stages of general anaesthesia. Inhaled and injected anaesthetics - classification and characteristics. Review of drugs used in premedication.
  • Co-talks.
  • Getting ready for the next lesson: : Allergic reactions – causes and mechamisms. Revision of PNS pharmacology - β2 mimetics, parasympatholytics. Glucocorticoids.Revision of blood coagulation.
  • Day 7 (Tuesday)
  • 11/ANTICOAGULANTS AND THROMBOLYTICS.
  • Fibrinolytics, haemostatics.
  • Co-talks.
  • 12/H1 ANTIHISTAMINES, TREATMENT OF BRONCHIAL OBSTRUCTION.
  • Classification and clinical use of H1 antihistamines.Sites of action and review of drugs of bronchial obstruction and other drugs acting in respiratory tract.
  • Co-talks.
  • Getting ready for the next lesson: : Drug dosage forms and external routes of drug administration, revision of drug prescription. Revision of prescription of drug dosage forms for external use.Physiology of blood pressure regulation. Revision of PNS pharmacology-α1 sympatotholytics, α2 sympathomimetics, β sympatholytics.
  • Day 8 (Wednesday)
  • FINAL PRESCRIPTION TEST (includes dermatology).
  • 13/HYPOLIPIDEMICS, THERAPY OF OBESITY.
  • Therapy of hyperlipoproteinaemia and hypercholesterolaemia, review of drugs and their mechanism of action.
  • 14/ANTIHYPERTENSIVE AGENTS.
  • Introduction, classification, diuretics, beta blockers, ACE inhibitors, Ca 2+ blockers, and other hypertensives.
  • Co-talks.
  • Getting ready for the next lesson: Revision of lessons 9-14.
  • Day 9 (Thursday)

    No classes.

  • Day 10 (Friday)
  • REVISING TEST III (Overhead-test with subsequent discussion). Lessons 9 - 14.
  • 15/CASE REPORTS III.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • CREDITS.
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
  • HADAŠOVÁ, Eva, Jana NOVÁKOVÁ, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ, Alexandra ŠULCOVÁ and Olga STAROBOVÁ. Praktická cvičení z farmakologie (Practical lessons on pharmacology). 2. opravené a doplněné vyd. Brno: Vydavatelství MU Brno-Kraví Hora, 2003. 110 pp. Skripta. ISBN 80-210-2694-4. info
  • Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    not specified
  • http://portal.med.muni.cz/disciplina-13-farmakologie
  • https://is.muni.cz/auth/el/1411/podzim2008/VLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=VLFA0722p
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Teaching methods
Drug classes specifics from the Syllabus are read firstly by the teacher and presented in case reports from real clinical praktické followed by discussion and training of drug prescription with the use of drug compendia and the computer database of the preparations registered in the Czech Republic (AISLP). Each student is asked to get ready as a homework to report on a specific pharmacological topic.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 4 written tests: a) 1 on special drug presriptions (assessed individually by the teacher), b) 3 multiple-choice tests on knowledge of topics taught (more than half correctly answered questions required).
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: in blocks.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2019.
  • Enrolment Statistics (autumn 2018, recent)
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