VLFA0722c Pharmacology II - practice

Faculty of Medicine
Autumn 2009
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
MVDr. Dagmar Vršková, Ph.D. (seminar tutor)
MUDr. Mgr. Karel Šlais, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Guaranteed by
prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Alexandra Šulcová, CSc.
Timetable of Seminar Groups
VLFA0722c/01: Mon 5. 10. to Tue 13. 10. each working day 7:30–12:20 N03206/206; and Wed 14. 10. 7:30–9:45 N03206/206
VLFA0722c/02: Mon 21. 9. to Tue 29. 9. each working day 7:30–12:20 N03206/206; and Wed 30. 9. 7:30–9:45 N03206/206
VLFA0722c/03: Mon 11. 1. to Tue 19. 1. each working day 7:30–12:20 N03206/206; and Wed 20. 1. 7:30–9:45 N03206/206
VLFA0722c/04: Mon 14. 12. to Fri 18. 12. each working day 7:30–12:20 N03206/206, Mon 4. 1. to Tue 5. 1. each working day 7:30–12:20 N03206/206; and Wed 6. 1. 7:30–9:45 N03206/206
VLFA0722c/05: Mon 30. 11. to Tue 8. 12. each working day 7:30–12:20 N03206/206; and Wed 9. 12. 7:30–9:45 N03206/206
VLFA0722c/06: Mon 16. 11. to Tue 24. 11. each working day 7:30–12:20 N03206/206; and Wed 25. 11. 7:30–9:45 N03206/206
VLFA0722c/07: Mon 2. 11. to Tue 10. 11. each working day 7:30–12:20 N03206/206; and Wed 11. 11. 7:30–9:45 N03206/206
VLFA0722c/08: Mon 19. 10. to Tue 27. 10. each working day 7:30–12:20 N03206/206; and Wed 28. 10. 7:30–9:45 N03206/206
VLFA0722c/09: Mon 16. 11. to Tue 24. 11. each working day 7:30–12:20 N03206/206; and Wed 25. 11. 7:30–9:45 N03206/206
VLFA0722c/10: Mon 2. 11. to Tue 10. 11. each working day 7:30–12:20 N03206/206; and Wed 11. 11. 7:30–9:45 N03206/206
VLFA0722c/11: Mon 19. 10. to Tue 27. 10. each working day 7:30–12:20 N03206/206; and Wed 28. 10. 7:30–9:45 N03206/206
VLFA0722c/12: Mon 5. 10. to Tue 13. 10. each working day 7:30–12:20 N03206/206; and Wed 14. 10. 7:30–9:45 N03206/206
VLFA0722c/15: Mon 14. 12. to Fri 18. 12. each working day 7:30–12:20 N03206/206, Mon 4. 1. to Tue 5. 1. each working day 7:30–12:20 N03206/206; and Wed 6. 1. 7:30–9:45 N03206/206
VLFA0722c/16: Mon 30. 11. to Tue 8. 12. each working day 7:30–12:20 N03206/206; and Wed 9. 12. 7:30–9:45 N03206/206
VLFA0722c/30: No timetable has been entered into IS.
VLFA0722c/31: No timetable has been entered into IS.
VLFA0722c/32: No timetable has been entered into IS.
VLFA0722c/33: No timetable has been entered into IS.
Prerequisites (in Czech)
VLFA0621c Pharmacology I - p && ( VSAJ0222 English 1 II -p || VSCJ0686 Czech for Foreigners VI -p || VSNJ0222 German 1 II -p || VSSJ0222 Spanish 1 II -p )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student should be able to prescribe representatives of individual drug classes in the form of individually prepared pharmaceutical preparation and bulk drugs. The student should be familiar with pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions.
Syllabus
  • SEMINARS
  • Day 1 (Mon)
  • Introduction, organisatory remarks. Distribution of co-talks: Antibiotics and chemotherapeutics (6 topics). Sulfonamides, trimethoprim. Quinolones. Antituberculous drugs. Antiretroviral antivirotics. Antiherpetics. Histamine, H 1-3 receptors. Therapy of anaphylactic shock. Immunostimulation. Immunosuppression.
  • 1/ANALGESICS.
  • Opioid and nonopioid analgesics. Pharmacotherapy of pain. Prescription and practical use of analgesic preparations.
  • 2/NON-STEROIDAL ANTIINFLAMMATORY DRUGS, DRUGS USED IN GOUT.
  • Mechanisms of action and classification of antiinflammatory and antirheumatic drugs (NSAIDs and the 2nd-line agents). Drugs used in therapy of gout.
  • Getting ready for the next lesson: NEW: Central neurotransmitters and sites of drug effects in CNS. Basic psychical functions. Revision: Authonomic nervous system (see spring semester).
  • Day 2 (Tue)
  • 3/PSYCHOTROPIC DRUGS.
  • Classification and terminology of psychotropics. Pharmacology of anxiolytics and hypnosedatives. Mechanism of action of benzodiazepines.
  • Work with PC - Microlabs, antidepressants. Prescription of hypnosedatives and psychostimulants.
  • 4/GENERAL ANAESTHETICS.
  • Combined and balanced anaesthesia. Signs and stages of general anaesthesia. Inhaled and injected anaesthetics - classification and characteristics.
  • Video-programme:General anaesthesia (cz).
  • Getting ready for the next lesson: Revision: L 1 - 4 (analgesics and antiinflammatory drugs, classification and basic characteristics of psychotropic drugs, general anaesthetics). NEW: Pathophysiology of bronchial asthma. Co-talks: Role of histamine in the organism, receptors. Therapy of anaphylactic shock.
  • Day 3 (Wed)
  • REVISING TEST I (Overhead-test with subsequent discussion) Analgesics and antiinflammatory drugs, classification and basic characteristics of psychotropic drugs, general anaesthetics.
  • 5/H1-ANTIHISTAMINES.
  • Classification and clinical use of H1-antihistamines.
  • Co-talk: Histamine; pathophysiological role, H1- H2 - H3 receptors.
  • 6/ANTIASTHMATICS.
  • Pathophysiology of bronchial asthma, sites and mechanisms of action of antiasthma drugs. Co-talk: Therapy of anaphylactic shock. Prescription of antitussives, expectorants, antiasthmatics.
  • Getting ready for the next lesson: Antimicrobial agents, mechanism of action, bacterial resistance. NEW: Co-talks: Narrow-spectrum and beta-lactamase resistant penicillins. Intermediate and broad-spectrum penicillins. Cephalosporins. Aminoglycosides. Macrolides, lincosamines. Chloramphenicol and tetracyclines. Antituberculous drugs. Sulphonamides and trimethoprim. Quinolones. Antiretroviral antivirotics. Antiherpetics.
  • Day 4 (Thu)
  • 7/ANTIMICROBIAL AGENTS.
  • Classification, mechanisms of action, combinations of antibiotics and chemotherapeutics.Co-talks.
  • 8/ANTIBACTERIAL CHEMOTHERAPEUTICS, ANTIVIRAL and ANTIFUNGAL AGENTS. Drugs acting in intestinal and urinary infections. Co-talks: Quinolones. Antiretroviral antivirotics. Antiherpetics. Antituberculous agents.
  • Getting ready for the next lesson: Revision: Authonomic nervous system. NEW: Diabetes mellitus. Peptic ulcer.
  • Day 5 (Fri)
  • PRESCRIPTION TEST: DRUGS ACTING IN CNS, RESPIRATORY TRACT (classified).
  • 9/LOCAL ANAESTHETICS.
  • Mechanism of action, classification, practical use and prescription.
  • 10/ANTICOAGULANTS AND THROMBOLYTICS.
  • Fibrinolytics, haemostatics, therapy of haemopoietic disorders
  • Getting ready for the next lesson: NEW: Adrenal corticosteroids. Anticancer agents. Co-talks: Immunosuppression, immunomodulation.
  • Day 6 (Mon)
  • REVISING TEST II (Overhead-test with subsequent discussion).
  • 11/GLUCOCORTICOIDS
  • Natural and synthetic adrenocorticosteroids, steroid receptors, mechanism of action, pharmacological use and side effects.
  • 12/PHARMACOLOGY OF ANTICANCER DRUGS. IMMUNOLOGICALLY ACTIVE SUBSTANCES. Classification, mechanisms of action, clinical use of anticancer agents.
  • Co-talks:Immunosuppression, immunomodulation.
  • Getting ready for the next lesson: Revision: Prescriptions of local anesthetics, selected surface-active drugs, ready-made preparations.
  • Day 7 (Tue)
  • FINAL PRESCRIPTION TEST (classified): Local anesthetics, selected surface-active drugs, ready-made preparations
  • 13/ANTIDIABETIC DRUGS.
  • Terapie IDDM, insuliny. Perorální antidiabetika. Příklady HVLP.
  • Co-talks.
  • 14/DRUGS USED IN ULCER DISEASE, ANTIEMETICS.
  • Classification, mechanisms of action and clinical use of drugs in therapy of peptic ulcer and vomiting.
  • Getting ready for the final test: Revision: L 1 - 14 (incl. local anesthetics, glucocorticoids, anticancer drugs, therapy of diabetes and ulcer disease.
  • Day 8 (Wed)
  • FINAL REVISING TEST (Overhead-test III, classified).
  • Substitution tests.
  • CREDITS.
Literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
  • HADAŠOVÁ, Eva, Jana NOVÁKOVÁ, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ, Alexandra ŠULCOVÁ and Olga STAROBOVÁ. Praktická cvičení z farmakologie (Practical lessons on pharmacology). 2. opravené a doplněné vyd. Brno: Vydavatelství MU Brno-Kraví Hora, 2003. 110 pp. Skripta. ISBN 80-210-2694-4. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • https://is.muni.cz/auth/el/1411/podzim2008/VLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=VLFA0722p
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • Lippincott's Illustrated Reviews : Pharmacology, 4th Ed., Harvey, Richard A. - Champe, Pamela C. - Finkel, Richard - Cubeddu, Luigi - Clarke, Michelle A. 2008. 560 s. ISBN-10: 0-7817-7155-2, ISBN-13: 978-0-7817-7155-9
  • RANG, H. P. Rang and Dale's pharmacology. 6th ed. [S.l.]: Churchill Livingstone, 2007. xiii, 829. ISBN 9780443069116. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
Teaching methods
Drug classes specifics from the Syllabus are read firstly by the teacher and presented in video-programmes if available followed by discussion and training of drug prescription with the use of drug compendia and the computer database of the preparations registered in the Czech Republic (AISLP). Each student is asked to get ready as a homework to report on a specific pharmacological topic.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 4 written tests: a) 2 on special drug presriptions (assessed individually by the teacher), b) 2 multiple-choice tests on knowledge of topics taught (more than half correctly answered questions required).
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019.
  • Enrolment Statistics (Autumn 2009, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2009/VLFA0722c