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Biochemistry II

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    Biochemie II - cvičení

    Course is complementary to aVLBC0422p. The aim of the course it to bring experience with solving practical problems in clinical biochemistry, to acquire practical laboratory skills and to learn students to use results of biochemical analysis for diagnostics.
    • Rozvrh seminárních/paralelních skupin:
      aVLBC0422c/30 Út 8:00–10:30 A16/216, M. Králíková
      aVLBC0422c/31 Út 8:00–10:30 A16/211, J. Smutná
      aVLBC0422c/32 Út 8:00–10:30 A16/212, H. Paulová
      aVLBC0422c/33 Čt 11:00–13:30 A16/211
      aVLBC0422c/34 Čt 11:00–13:30 A16/212, M. Tomandlová
      aVLBC0422c/35 Čt 14:00–16:30 A16/211, J. Slanina
      aVLBC0422c/36 Čt 14:00–16:30 A16/212, J. Gregorová
      aVLBC0422c/37 Čt 11:00–13:30 A16/216, O. Peš
    • Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
    Vyučující
    cvičící Mgr. Jana Gregorová, Ph.D. Mgr. Jana Gregorová, Ph.D.
    (cvičící)
    cvičící doc. PharmDr. Jiří Kos, Ph.D. doc. PharmDr. Jiří Kos, Ph.D.
    (cvičící)
    cvičící MUDr. Michaela Králíková, Ph.D. MUDr. Michaela Králíková, Ph.D.
    (cvičící)
    cvičící RNDr. Hana Paulová, CSc. RNDr. Hana Paulová, CSc.
    (cvičící)
    cvičící doc. Mgr. Ondřej Peš, Ph.D. doc. Mgr. Ondřej Peš, Ph.D.
    (cvičící)
    cvičící Mgr. Jiří Slanina, Ph.D. Mgr. Jiří Slanina, Ph.D.
    (cvičící)
    cvičící Mgr. Jindra Smutná, Ph.D. Mgr. Jindra Smutná, Ph.D.
    (cvičící)
    cvičící doc. RNDr. Josef Tomandl, Ph.D. doc. RNDr. Josef Tomandl, Ph.D.
    (cvičící)
    cvičící Mgr. Marie Tomandlová, Ph.D. Mgr. Marie Tomandlová, Ph.D.
    (cvičící)
    Osnova
      • Introduction to practice - organization, work and safety principles, principles of pipetting
      • Selected examinations of glucose metabolism - P/B/U-glucose, glycemic profile, OGTT, U-ketone bodies
      • Selected examinations of lipid and cholesterol metabolism - S/B-cholesterol, S-TG, S-LDL/HDL/non-HDL-cholesterol
      • Selected liver tests - ALT/AST, S/U-bilirubin, U-UBG
      • Investigation of proteins in blood serum - S-total protein, S-albumin, electrophoresis, S/B-CRP, S-ferritin
      • Selected kidney examinations - S/U-creatinine, creatinine clearance, eGFR, FR and FE water, U-proteins, U-albumin, S/U-urea, nitrogen balance
      • Chemical qualitative analysis of urine - diagnostic strips
      • Selected examinations of urolithiasis - S/U-uric acid, stones
    Informace učitele
    Detailed information on the teaching and completion of the course is given in the Study Materials in IS MU.
    A white coat, slippers or sturdy shoes with overshoes, gloves, and a calculator are required for the exercise.

    Biochemie II - přednáška

    The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic of individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
    • Rozvrh: jaro 2026
      Pá 8:00–9:50 B11/334
    • Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
    Vyučující
    přednášející doc. RNDr. Jiří Dostál, CSc. doc. RNDr. Jiří Dostál, CSc.
    (přednášející)
    přednášející MUDr. Michaela Králíková, Ph.D. MUDr. Michaela Králíková, Ph.D.
    (přednášející)
    přednášející RNDr. Hana Paulová, CSc. RNDr. Hana Paulová, CSc.
    (přednášející)
    přednášející Mgr. Jiří Slanina, Ph.D. Mgr. Jiří Slanina, Ph.D.
    (přednášející)
    přednášející prof. RNDr. Eva Táborská, CSc. prof. RNDr. Eva Táborská, CSc.
    (přednášející)
    přednášející doc. RNDr. Josef Tomandl, Ph.D. doc. RNDr. Josef Tomandl, Ph.D.
    (přednášející)
    Osnova
      • Blood plasma lipids. Metabolism of lipoproteins.
      • Overview of nutrient metabolism in different states.
      • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
      • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
      • Water and Na+, K+ ions balance, osmolality and volume of ECF.
      • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
      • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
      • General mechanisms of action of signal molecules. Hormone receptors.
      • Steroid and thyroid hormones.
      • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
      • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
      • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
      • Extracellular matrix. Bone tissue. Articular cartilage and skin.
      • Biochemistry of blood cells. Major proteins of blood plasma.
    Informace učitele
    Information about the exam and topics included in the exam is available in the IS MU Study Materials - Organizational Instructions.

    Biochemie II - seminář

    Seminars are complementary to the course Biochemistry II - lecture. The aim of the course is to practise (i) the basic principles of intermediary metabolism and its regulation in various states of the organism at all levels, (ii) the characteristic features of metabolism of individual organs and tissues, (iii) the principles of maintaining homeostasis of the organism, including acid-base balance.
    • Rozvrh seminárních/paralelních skupin:
      aVLBC0422s/30 Po 11:00–13:50 A16/215, J. Dostál, H. Paulová
      aVLBC0422s/31 Po 11:00–13:50 A16/215, J. Dostál, H. Paulová
      aVLBC0422s/32 Po 8:00–10:50 A16/213, E. Táborská
      aVLBC0422s/33 Po 11:00–13:50 A16/213, H. Paulová, J. Tomandl
      aVLBC0422s/34 Út 14:00–16:50 A16/215, H. Paulová, J. Tomandl
      aVLBC0422s/35 Po 11:00–13:50 A16/213, H. Paulová, J. Tomandl
      aVLBC0422s/36 Út 14:00–16:50 A16/215, H. Paulová, J. Tomandl
      aVLBC0422s/37 Po 8:00–10:50 A16/213, E. Táborská
    • Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
    Vyučující
    cvičící doc. RNDr. Jiří Dostál, CSc. doc. RNDr. Jiří Dostál, CSc.
    (cvičící)
    cvičící prof. RNDr. Eva Táborská, CSc. prof. RNDr. Eva Táborská, CSc.
    (cvičící)
    cvičící doc. RNDr. Josef Tomandl, Ph.D. doc. RNDr. Josef Tomandl, Ph.D.
    (cvičící)
    Osnova
      • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry. Analysers, POCT.
      • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
      • Lipoproteins and their metabolism. Cholesterol transport and balance.
      • Relationships between major metabolic pathways of essential nutrients in various states. Malnutrition. Obesity. Metabolic syndrome. Metabolism during stress.
      • Liver functions, role in nutrient metabolism. Heme catabolism, hyperbilirubinemia. Role of liver in metabolism of hormones and vitamins. Metabolism of Fe.
      • Biotransformation of xenobiotics. Metabolism of ethanol.
      • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volemia.
      • Acid-base balance, parameters, regulation, disorders. Buffer bases. Transport of O2 a CO2.
      • Major functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
      • Neurotransmitters and hormone receptors. The most common signal pathways.
      • Steroid and thyroid hormones.
      • Biochemistry of muscle work. Effect of NO. Energetics of muscle work.
      • Metabolism of Ca, Mg, P, F, I.
      • Extracellular matrix. Metabolism of connective tissue and skin, bone biomarkers.
    Informace učitele
    Detailed information on the teaching and completion of the course is given in the Study Materials in IS MU.
    Consultations are possible after a personal arrangement with the teacher.

    Biochemie II laboratorní medicína - seminář

    The course combines theoretical biochemistry knowledge with clinical applications.
    The aim of the course is to provide information about the importance of clinical biochemistry and its implementation, factors affecting laboratory results, the importance of biological variability and its application in the evaluation of results, diagnostic effectiveness of laboratory tests. The aim of the course is also to acquaint students in more detail with some specific biochemical tests, such as disorders of carbohydrate metabolism, liver and heart disease, assessment of renal function, and examination of urine and cerebrospinal fluid.
    • Rozvrh seminárních/paralelních skupin:
      aVLBC0422t/30 St 18. 2. 11:30–13:10 A16/215, St 25. 2. 11:30–13:10 A16/215, St 4. 3. 11:30–13:10 A16/215, St 11. 3. 11:30–13:10 A16/215, St 18. 3. 11:30–13:10 A16/215, St 25. 3. 11:30–13:10 A16/215, St 1. 4. 11:30–13:10 A16/215, St 8. 4. 11:30–13:10 A16/215, St 15. 4. 11:30–13:10 A16/215, St 22. 4. 11:30–13:10 A16/215, J. Dostál, H. Paulová
      aVLBC0422t/31 St 18. 2. 11:30–13:10 A16/215, St 25. 2. 11:30–13:10 A16/215, St 4. 3. 11:30–13:10 A16/215, St 11. 3. 11:30–13:10 A16/215, St 18. 3. 11:30–13:10 A16/215, St 25. 3. 11:30–13:10 A16/215, St 1. 4. 11:30–13:10 A16/215, St 8. 4. 11:30–13:10 A16/215, St 15. 4. 11:30–13:10 A16/215, St 22. 4. 11:30–13:10 A16/215, J. Dostál, H. Paulová
      aVLBC0422t/32 Út 17. 2. 17:00–18:40 A16/213, Út 24. 2. 17:00–18:40 A16/213, Út 3. 3. 17:00–18:40 A16/213, Út 10. 3. 17:00–18:40 A16/213, Út 17. 3. 17:00–18:40 A16/213, Út 24. 3. 17:00–18:40 A16/213, Út 31. 3. 17:00–18:40 A16/213, Út 7. 4. 17:00–18:40 A16/213, Út 14. 4. 17:00–18:40 A16/213, Út 21. 4. 17:00–18:40 A16/213, J. Slanina
      aVLBC0422t/33 Út 17. 2. 17:00–18:40 A16/213, Út 24. 2. 17:00–18:40 A16/213, Út 3. 3. 17:00–18:40 A16/213, Út 10. 3. 17:00–18:40 A16/213, Út 17. 3. 17:00–18:40 A16/213, Út 24. 3. 17:00–18:40 A16/213, Út 31. 3. 17:00–18:40 A16/213, Út 7. 4. 17:00–18:40 A16/213, Út 14. 4. 17:00–18:40 A16/213, Út 21. 4. 17:00–18:40 A16/213, J. Slanina
      aVLBC0422t/34 Pá 20. 2. 13:00–14:40 A16/215, Pá 27. 2. 13:00–14:40 A16/215, Pá 6. 3. 13:00–14:40 A16/215, Pá 13. 3. 13:00–14:40 A16/215, Pá 20. 3. 13:00–14:40 A16/215, Pá 27. 3. 13:00–14:40 A16/215, Pá 10. 4. 13:00–14:40 A16/215, Pá 17. 4. 13:00–14:40 A16/215, Pá 24. 4. 13:00–14:40 A16/215, M. Králíková
      aVLBC0422t/35 Pá 20. 2. 13:00–14:40 A16/215, Pá 27. 2. 13:00–14:40 A16/215, Pá 6. 3. 13:00–14:40 A16/215, Pá 13. 3. 13:00–14:40 A16/215, Pá 20. 3. 13:00–14:40 A16/215, Pá 27. 3. 13:00–14:40 A16/215, Pá 10. 4. 13:00–14:40 A16/215, Pá 17. 4. 13:00–14:40 A16/215, Pá 24. 4. 13:00–14:40 A16/215, M. Králíková
      aVLBC0422t/36 St 18. 2. 11:30–13:10 A16/213, St 25. 2. 11:30–13:10 A16/213, St 4. 3. 11:30–13:10 A16/213, St 11. 3. 11:30–13:10 A16/213, St 18. 3. 11:30–13:10 A16/213, St 25. 3. 11:30–13:10 A16/213, St 1. 4. 11:30–13:10 A16/213, St 8. 4. 11:30–13:10 A16/213, St 15. 4. 11:30–13:10 A16/213, St 22. 4. 11:30–13:10 A16/213, J. Slanina, J. Tomandl
      aVLBC0422t/37 St 18. 2. 11:30–13:10 A16/213, St 25. 2. 11:30–13:10 A16/213, St 4. 3. 11:30–13:10 A16/213, St 11. 3. 11:30–13:10 A16/213, St 18. 3. 11:30–13:10 A16/213, St 25. 3. 11:30–13:10 A16/213, St 1. 4. 11:30–13:10 A16/213, St 8. 4. 11:30–13:10 A16/213, St 15. 4. 11:30–13:10 A16/213, St 22. 4. 11:30–13:10 A16/213, J. Slanina, J. Tomandl
    • Lékařská fakulta
    Vyučující
    cvičící doc. RNDr. Josef Tomandl, Ph.D. doc. RNDr. Josef Tomandl, Ph.D.
    (cvičící)
    cvičící doc. RNDr. Jiří Dostál, CSc. doc. RNDr. Jiří Dostál, CSc.
    (cvičící)
    cvičící MUDr. Michaela Králíková, Ph.D. MUDr. Michaela Králíková, Ph.D.
    (cvičící)
    cvičící RNDr. Hana Paulová, CSc. RNDr. Hana Paulová, CSc.
    (cvičící)
    cvičící Mgr. Jiří Slanina, Ph.D. Mgr. Jiří Slanina, Ph.D.
    (cvičící)
    cvičící prof. RNDr. Eva Táborská, CSc. prof. RNDr. Eva Táborská, CSc.
    (cvičící)
    Osnova
      • Factors influencing results of laboratory examinations, preanalytical factors. Collection and processing of blood. Communicating results of biochemical examination
      • Analytical factors influencing results of laboratory examinations. Validation and interpretation of results, critical difference. Diagnostic accuracy.
      • Biochemical examinations in diabetes mellitus. Laboratory control of the disease.
      • Biochemical investigations of lipid metabolism. Atherosclerosis risk factors.
      • Laboratory tests in myocardial infarction.
      • Biochemical examinations of liver diseases, laboratory diagnostics of hyperbilirubinemia. Laboratory examination of specific liver diseases.
      • Laboratory examination of the gastrointestinal tract.
      • Urine sampling and collection. Physical and chemical examination of urine.
      • Examination of glomerular filtration. Examination of renal tubular function. Examination for urolithiasis.
      • Cerebrospinal fluid analysis.
    Informace učitele
    Detailed information on the teaching and completion of the course is given in the Study Materials in IS MU.
    Consultations are possible after a personal arrangement with the teacher.

Celková cena: 30 000 Kč vč. DPH

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